Skip to main content
×
×
Home

Maternal verbally aggressive behavior in early infancy is associated with blood pressure at age 5–6

  • L. J. C. A. Smarius (a1) (a2) (a3), T. G. A. Strieder (a4), T. A. H. Doreleijers (a3), T. G. M. Vrijkotte (a1) and S. R. de Rooij (a1) (a5)...
Abstract

Early life stress has been shown to contribute to alterations in biobehavioral regulation. Whereas many different forms of childhood adversities have been studied in relation to cardiovascular outcomes, very little is known about potential associations between caregivers’ verbally aggressive behavior and heart rate and blood pressure in the child. This prospective study examined whether maternal verbally aggressive behavior in early infancy is associated with heart rate or blood pressure at age 5–6. In the Amsterdam Born Children and their Development study, a large prospective, population-based birth cohort, maternal verbally aggressive behavior was assessed by questionnaire in the 13th week after birth. The child’s blood pressure and heart rate were measured during rest at age 5–6 (n=2553 included). Maternal verbally aggressive behavior in infancy was associated with a higher systolic blood pressure (SBP) both in supine and sitting position after adjustment for sex, height and age (SBP supine B=1.01 mmHg; 95% CI [0.06; 1.95] and SPB sitting B=1.29 mmHg; 95% CI [0.12; 2.46]). Adjustment for potential confounding variables, such as other mother–infant dyad aspects, family hypertension and child’s BMI, only slightly attenuated the associations (SBP supine B=0.99 mmHg; 95% CI [0.06; 1.93] and SPB sitting B=1.11 mmHg; 95% CI [−0.06; 2.27]). Maternal verbally aggressive behavior was not associated with diastolic blood pressure or heart rate at age 5–6. Maternal verbally aggressive behavior might be an important early life stressor with negative impact on blood pressure later in life, which should be further investigated. Possible underlying mechanisms are discussed.

Copyright
Corresponding author
*Address for correspondence: L. J. C. A. Smarius, Department of Public Health, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands. E-mail: laetitiasmarius@online.nl
References
Hide All
1. Loria, AS, Ho, DH, Pollock, JS. A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood. Acta Physiol (Oxf). 2014; 210, 277287.
2. Murphy, MO, Cohn, DM, Loria, AS. Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents. Neurosci Biobehav Rev. 2017; 74, 453465.
3. Theodore, AD, Chang, JJ, Runyan, DK, et al. Epidemiologic features of the physical and sexual maltreatment of children in the Carolinas. Pediatrics. 2005; 115, e331e337.
4. Parrish, C, Surkan, PJ, Martins, SS, et al. Childhood adversity and adult onset of hypertension and heart disease in São Paulo, Brazil. Prev Chronic Dis. 2013; 10, E205.
5. Slopen, N, Non, A, Williams, DR, Roberts, AL, Albert, MA. Childhood adversity, adult neighborhood context, and cumulative biological risk for chronic diseases in adulthood. Psychosom Med. 2014; 76, 481489.
6. Su, S, Wang, X, Pollock, JS, et al. Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood: the Georgia stress and Heart study. Circulation. 2015; 131, 16741681.
7. Pretty, C, O’Leary, DD, Cairney, J, Wade, TJ. Adverse childhood experiences and the cardiovascular health of children: a cross-sectional study. BMC Pediatr. 2013; 17, 208.
8. Lambregtse-van den Berg, MP, Lucassen, N, Kuipers-Nap, MF, et al. Assessing expressed emotion during pregnancy. Psychiatry Res. 2013; 205, 285288.
9. Seltzer, LJ, Ziegler, TE, Pollak, SD. Social vocalizations can release oxytocin in humans. Procedings. Biological Sciences. 2010; 277, 26612666.
10. MacLean, PC, Rynes, KN, Aragón, C, et al. Mother-infant mutual eye gaze supports emotion regulation in infancy during the Still-Face paradigm. Infant Behav Dev. 2014; 37, 512522.
11. Naughton, AM, Maguire, SA, Mann, MK, et al. Emotional, behavioral, and developmental features indicative of neglect or emotional abuse in preschool children: a systematic review. JAMA Pediatr. 2013; 167, 769775.
12. Brummelte, S, Galea, LA. Postpartum depression: etiology, treatment and consequences for maternal care. Horm Behav. 2016; 77, 153166.
13. Dollberg, D, Feldman, R, Keren, M. Maternal representations, infant psychiatric status, and mother-child relationship in clinic-referred and non-referred infants. Eur Child Adolesc Psychiatry. 2010; 19, 2536.
14. Van Eijsden, E, Vrijkotte, TGM, Gemke, RJBJ, van der Wal, MF. Cohort profile: The Amsterdam Born Children and their Development (ABCD) study. Int J Epidemiol. 2011; 40, 11761186.
15. de Geus, EJ, Willemsen, GH, Klaver, CH, van Doornen, LJ. Ambulatory measurement of respiratory sinus arrhythmia and respiration rate. Biol Psychol. 1995; 41, 205227.
16. Van Dijk, AE, van Lien, R, van Eijsden, M, et al. Measuring cardiac autonomic nervous system (ANS) activity in children. J Vis Exp. 2013; 74, e50073.
17. Van der Wal, MF, van Eijsden, M, Bonsel, GJ. Stress and emotional problems during pregnancy and excessive infant crying. J Dev Behav Paediatr. 2007; 28, 431437.
18. Smarius, LJ, Strieder, TG, Loomans, EM, et al. Excessive infant crying doubles the risk of mood and behavioral problems at age 5: evidence for mediation by maternal characteristics. Eur Child Adolesc Psychiatry. 2017; 26, 293302.
19. Knight, RG, Williams, S, McGee, R, Olaman, S. Psychometric properties of the Centre for Epidemiologic Studies Depression Scale (CES-D) in a sample of women in middle life. Behav Res Ther. 1997; 35, 373380.
20. van Dijk, A E, van Eijsden, M, Stronks, K, Gemke, R J, Vrijkotte, TG. The association between prenatal psychosocial stress and blood pressure in the child at age 5-7 years. PLoS One. 2012; 7, e43548.
21. Robinson, CC, Mandleco, B, Olsen, SF, Hart, CH. The Parenting Styles and Dimensions Questionnaire (PSDQ). In: Handbook of Family Measurement Techniques (eds. Perlmutter BF, Touliatos J, Holden GW), 2001; pp. 319321. Sage: Thousand Oaks.
22. de Brock, AJ, Vermulst, AA, Gerris, JR, Abidin, RR. NOSI, handleiding experimentele versie [NOSI, manual experimental version in Dutch]/Parenting Stress Index. 1992. Pearson: Amsterdam.
23. Henry, JD, Crawford, JR. The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Br J Clin Psychol. 2005; 44, 227239.
24. Gooding, HC, Milliren, CE, Austin, SB, Sheridan, MA, McLaughlin, KA. Child abuse, resting blood pressure, and blood pressure reactivity to psychosocial stress. J Pediatr Psychol. 2016; 41, 514.
25. Chen, X, Wang, Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation. 2008; 117, 31713180.
26. Toschke, AM, Kohl, L, Mansmann, U, von Kries, R. Meta-analysis of blood pressure tracking from childhood to adulthood and implications for the design of intervention trials. Acta Paediatr. 2010; 99, 2429.
27. Galea, S, Tracy, M. Participation rates in epidemiological studies. Ann Epidemiol. 2007; 17, 643653.
28. Johansson, S, Norman, M, Legnevall, L, et al. Increased catecholamines and heart rate in children with low birth weight: perinatal contributions to sympathoadrenal overactivity. J Intern Med. 2007; 261, 480487.
29. Cassidy, J, Mohr, JJ. Unsolvable fear, trauma and psychopathology; theory, research and clinical considerations related to disorganized attachment across the live cycle. Clin Psychol. 2001; 8, 275298.
30. Liotti, G. Trauma, dissociation and disorganized attachment: three stands of a single braid. Psychotherapy. 2004; 41, 472486.
31. Schore, AN. Affect Dysregulation and the Disorders of the Self. 2003. Norton: New York.
32. Pesonen, AK, Räikkönen, K, Feldt, K, et al. Childhood separation experience predicts HPA axis hormonal responses in late adulthood: a natural experiment of World War II. Psychoneuroendocrinology. 2010; 35, 758767.
33. Danese, A, McEwen, BS. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav. 2012; 106, 2939.
34. Pervanidou, P, Chrousos, GP. Metabolic consequences of stress during childhood and adolescence. Metabolism. 2012; 61, 611619.
35. Boyne, MS, Woollard, A, Phillips, DI, et al. The association of hypothalamic-pituitary-adrenal axis activity and blood pressure in an Afro-Caribbean population. Psychoneuroendocrinology. 2009; 34, 736742.
36. Krishnaveni, GV, Veena, SR, Dhube, A, et al. Size at birth, morning cortisol and cardiometabolic risk markers in healthy Indian children. Clin Endocrinol (Oxf). 2014; 80, 7379.
37. Nuyt, AM, Alexander, BT. Developmental programming and hypertension. Curr Opin Nephrol Hypertens. 2009; 18, 144152.
38. Fan, Y, Herrera-Melendez, AL, Pestke, K, et al. Early life stress modulates amygdala-prefrontal functional connectivity: implications for oxytocin effects. Hum Brain Mapp. 2014; 35, 53285339.
39. Shin, LM, Wright, CI, Cannistraro, PA, et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry. 2005; 62, 273281.
40. Bremner, JD, Vermetten, E, Schmahl, C, et al. Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder. Psychol Med. 2005; 35, 791806.
41. Tawakol, A, Ishai, A, Takx, RA, et al. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. Lancet. 2017; 389, 834845.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Developmental Origins of Health and Disease
  • ISSN: 2040-1744
  • EISSN: 2040-1752
  • URL: /core/journals/journal-of-developmental-origins-of-health-and-disease
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed