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The migration and attrition of Strongyloides ratti in naive and sensitized rats

Published online by Cambridge University Press:  05 June 2009

T.D. McHugh ,
T. Jenkins ,
R. Greenwood  and
D.J. McLaren
T.D. McHugh
Affiliation:
School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK
T. Jenkins
Affiliation:
School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK
R. Greenwood
Affiliation:
School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK
D.J. McLaren
Affiliation:
National Institute of Medical Research, Mill Hill, London, NW7 1AA, UK
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Abstract

Compressed organ autoradiography has been utilized to study the migration of the homogonic strain of Strongyloides ratti from the site of skin penetration to the gut. This transit is characterized by rapid disappearance of parasites from the cutaneous site of infection, followed by vascular dispersal throughout all organs investigated. For the first time, parasite migration in both naive and previously sensitized hosts is compared; the principal stations of migration are the same in the two groups although there is a quantitative difference in accumulation of parasites with time in these stations. Parasite attrition occurs in both groups of animals; however, in naive rats it is not manifest until day 20–25 post challenge, whereas in sensitized rats immune elimination occurs as early as 48 h post challenge.

Type
Research Papers
Information
Journal of Helminthology , Volume 68 , Issue 2 , June 1994 , pp. 143 - 148
Copyright
Copyright © Cambridge University Press 1994

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References

Abadie, S.H. (1963) The life cycle of Strongyloides ratti. Journal of Parasitology 49, 241–248.CrossRefGoogle ScholarPubMed
Abe, Y., Tanaka, H., Nagano, K. & Izumi, M. (1966) Histological studies on the larval migration of Strongyloides ratti in the cephalic portion of the albino rat. Japanese Journal of Parasitology 15, 310. (Abstract)Google Scholar
Aikens, L.M. & Schad, G.A. (1989) Radiolabelling of infective third-stage larvae of Strongyloides stercoralis by feeding [75Se] selenomethionine-labelled Escherichia coli to first-and second-stage larvae. Journal of Parasitology 75, 735–739.CrossRefGoogle Scholar
Bell, R.G., Adams, L.S. & Gerb, J. (1981) Strongyloides ratti; dissociation of the rat's protective immunity into systemic and intestinal components. Experimental Parasitology 52, 386–395.CrossRefGoogle ScholarPubMed
Bhopale, Y.M., Smith, G., Jordan, H.E. & Schad, G.A. (1992) Developmental biology and migration of Strongyloides ratti in the rat. Journal of Parasitology 78, 861–868.CrossRefGoogle ScholarPubMed
Chandiwana, S.K. (1988) Use of 75Se tracer and autoradiographic techniques in the study of schistosomiasis. Parasitology 97, 489–502.CrossRefGoogle Scholar
Dawkins, H.J.S., Muir, G.M. & Grove, D.I. (1981) Histopathological appearances in primary and secondary infections with Strongyloides ratti in mice. International Journal for Parasitology 11, 97–103.CrossRefGoogle ScholarPubMed
Dawkins, H.J.S., Thomason, H.J. & Grove, D.I. (1982) The occurrence of Strongyloides ratti in the tissues of mice after percutaneous infection. Journal of Helminthology 56, 45–50.CrossRefGoogle ScholarPubMed
Dixon, W.J., Brown, M.B., Engelman, L., Hill, M.A. & Jennrich, R.I. (1988) BMDP Statistical software manual, Vol. 1. University of California Press, Berkeley.Google Scholar
Genta, R.M. & Ward, P.A. (1980) The histopathology of experimental strongyloidiasis. American Journal of Pathology 99, 207–220.Google ScholarPubMed
Greenacre, M.J. (1984) Theory and Applications of Correspondence Analysis. Academic Press, London.Google Scholar
Kamiya, H., Smithers, S.R. & McLaren, D.J. (1987) Schistosoma mansoni: autoradiographic tracking studies of isotopically-labelled challenge parasites in naive and vaccinated CBA/Ca mice. Parasite Immunology 9, 515–529.CrossRefGoogle ScholarPubMed
Kwansa, H.E.A. & Murrell, K.D. (1985) In vivo tracking of the migration of Strongyloides ratti in the rat with selenium-75 labelled third stage larvae (L3). pp. 225–236in Hayunga, E.G. & Stek, M. Jr (Eds) Nuclear and related techniques in parasitology. Vienna, International Atomic Energy Agency.Google Scholar
McHugh, T.D., Jenkins, T. & McLaren, D.J. (1989) Strongyloides ratti: studies of cutaneous reactions elicited in naive and sensitised rats and of changes in surface antigenicity of skin-penetrating larvae. Parasitology 98, 95–103.CrossRefGoogle ScholarPubMed
Mimori, T., Korenaga, M., Chowdhury, N. & Tada, I. (1982) Growth and morphological changes of Strongyloides ratti in rats. Japanese Journal of Parasitology 31, 361–368.Google Scholar
Moqbel, R. (1980) Histopathological changes following primary, secondary and repeated infection of rats with Strongyloides ratti, with special reference to tissue eosinophils. Parasite Immunology 2, 11–27.CrossRefGoogle Scholar
Smithers, S.R. & Terry, R.J. (1965) Infection of laboratory hosts with cercariae of Schistosoma mansoni and recovery of adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Spindler, L.A. (1958) The occurrence of the intestinal threadworm Strongyloides ratti in the tissues of rats following experimental percutaneous infection. Proceedings of the Helminthological Society of Washington 25, 106–111.Google Scholar
Tada, I., Mimori, T. & Nakai, M. (1979) Migration route of Strongyloides ratti in albino rats. Japanese Journal of Parasitology 28, 219–227.Google Scholar
Tanaka, M., Mimori, T., Minematsu, T. & Tada, I. (1989) The acquirement of growth ability for third-stage larvae of Strongyloides ratti during the head-passage in the rat. International Journal for Parasitology 19, 757–760.CrossRefGoogle ScholarPubMed
Tindall, N.R. & Wilson, P.A.G. (1988) Criteria for a proof of migration routes of immature parasites inside hosts exemplified by studies of Strongyloides ratti in the rat. Parasitology 96, 551–563.CrossRefGoogle ScholarPubMed
Tindall, N.R. & Wilson, P.A.G. (1990a) A basis to extend the proof of migratory routes of immature parasites inside hosts: estimated time of arrival of Nippostrongylus brasiliensis and Strongyloides ratti in the gut of rats. Parasitology 100, 275–280.CrossRefGoogle Scholar
Tindall, N.R. & Wilson, P.A.G. (1990b) An extended proof of migratory routes of immature parasites inside hosts: pathways of Nippostrongylus brasiliensis and Strongyloides ratti in the rat are mutually exclusive. Parasitology 100, 281–288.CrossRefGoogle Scholar
Wertheim, G. & Lengy, J. (1965) Growth and development of Strongyloides ratti Sandground, 1925, in the albino rat. Journal of Parasitology 51, 636–639.CrossRefGoogle ScholarPubMed
Wilson, P.A.G. (1979) Tracking radioactive larvae of Strongyloides ratti in the host. Parasitology 79, 29–38.CrossRefGoogle ScholarPubMed
Wilson, P.A.G. & Simpson, N.E. (1981) Dynamics of infection in rats given low doses of homogonic and heterogonic Strongyloides ratti. Parasitology 83, 459–475.CrossRefGoogle Scholar
Wilson, P.A.G. & Simpson, N.E. (1982) Strongyloides ratti: studies of 75Se-labelled larvae of the homogonic strain in female hosts. Parasitology 84, 443–454.CrossRefGoogle ScholarPubMed
Wilson, P.A.G. & Simpson, N.E. & Seaton, D.S. (1986) The effect of method of infection on the pathway of juvenile Strongyloides ratti in the host. Journal of Helminthology 60, 79–91.CrossRefGoogle ScholarPubMed