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The protective effect of Ginkgo biloba extract against experimental cisplatin ototoxicity: animal research using distortion product otoacoustic emissions

Published online by Cambridge University Press:  14 September 2012

B Cakil
Affiliation:
Department of ENT, Ondokuz Mayis University School of Medicine, Samsun, Turkey
F Suren Basar*
Affiliation:
Department of Audiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey
S Atmaca
Affiliation:
Department of ENT, Ondokuz Mayis University School of Medicine, Samsun, Turkey
S Kurnaz Cengel
Affiliation:
Department of ENT, Ondokuz Mayis University School of Medicine, Samsun, Turkey
A Tekat
Affiliation:
Department of ENT, Ondokuz Mayis University School of Medicine, Samsun, Turkey
Y Tanyeri
Affiliation:
Department of ENT, Ondokuz Mayis University School of Medicine, Samsun, Turkey
*
Address for correspondence: Dr F Suren Basar, Ondokuz Mayis Üniversitesi Hastanesi, KBB Anabilim Dali, Odyoloji Ünitesi, Kurupelit 55139, Samsun, Turkey Fax: +90 362 457 6041 E-mail: figensuren@gmail.com

Abstract

Background:

Cisplatin, an effective therapeutic agent for various human cancers, has dose-limiting side effects of ototoxicity and nephrotoxicity. Cisplatin ototoxicity is thought to result from increased amounts of toxic free radicals or cell membrane changes leading to increased intracellular calcium content. Ginkgo biloba extract prevents lipid peroxidation, decreases intracellular free oxygen radical levels, regulates the cell membrane calcium transport mechanism and prevents cell death. This study aimed to investigate the protective effect of Ginkgo biloba extract against cisplatin-induced ototoxicity in rats.

Methods:

Twenty Wistar albino rats with normal hearing (confirmed by distortion product otoacoustic emission testing prior to cisplatin application) were randomly allocated to two groups. Both groups received a single intraperitoneal dose of cisplatin (12 mg/kg). Group two also received daily intraperitoneal doses of Ginkgo biloba extract (100 mg/kg) for 10 days. Distortion product otoacoustic emission measurements were repeated on days 10 and 17 and signal-to-noise ratios were compared.

Results:

Compared with group one, group two had significantly better distortion product otoacoustic emission results at 3, 4, 6 and 8 kHz on days 10 and 17.

Conclusion:

These findings suggest that Ginkgo biloba extract protects the inner ear against cisplatin-induced ototoxicity.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2012

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Footnotes

Presented at the 30th Turkish National Otorhinolaryngology and Head and Neck Surgery Congress, 8–12 October 2008, Antalya, Turkey

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