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Diagnostic imaging of the larynx: autofluorescence of laryngeal tumours using the helium-cadmium laser

  • Meredydd Lloyd Harries (a1), Stephen Lam (a2), Calum MacAulay (a2), Jianan Qu (a2) and Branko Palcic (a2)
  • DOI:
  • Published online: 01 June 2007

The use of tissue autofluorescence for the detection and localization of cancer of the larynx is described. In this pilot study, eight patients with probable carcinoma of the vocal folds underwent laryngoscopy in which the tissue autofluorescence spectra of normal and pathologically confirmed tumour tissue were acquired in vivo. Fluorescence images of the suspect areas were also acquired using the LIFE system (Xillix Technologies Corp.). The results suggest that the autofluorescence properties of laryngeal tissue, under 442 nm illumination, are similar to those of bronchial tissue and that the LIFE system has the potential to increase the accuracy of staging of cancer of the larynx and also to allow earlier diagnosis of tumours and theirrecurrence

Corresponding author
Address for correspondence: Mr M. L. Harries, The Voice Clinic, Royal National Throat, Nose and Ear Hospital, 330 Gray's Inn Road, London WCIX 8DA.
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J. Hung , S. Lam , J. J. LeRiche (1991) Autofluorescence of normal and malignant bronchial tissue. Lasers in Surgery and Medicine 11: 99105.

B. Palcic , S. Lam , J. Hung , C. MacAulay (1991) Detection and localization of early lung cancer by imaging techniques. Chest 99:742743.

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  • ISSN: 0022-2151
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