Skip to main content
×
Home
    • Aa
    • Aa

The effect of local application of insulin-like growth factor for prevention of inner-ear damage caused by electrode trauma

  • H Gur (a1), Y Alimoglu (a2), U Duzenli (a1), S Korkmaz (a1), S Inan (a3) and L Olgun (a1)...
Abstract
Abstract Background:

Electrode insertion during cochlear implantation causes cochlear damage and apoptosis. Insulin-like growth factor applied locally was investigated in 21 rats.

Methods:

In the sham group, an intracochlear dummy electrode was inserted through the round window. In the control group, after the same insertion procedure, saline-soaked porcine skin gelatine was placed on the round window. In the study group, insulin-like growth factor 1 soaked gelatine was placed on the round window. Auditory brainstem response thresholds were measured and histopathological examination was performed.

Results:

In the study group, at 2–4 kHz, one rat had deterioration, one showed improvement and the rest had stable thresholds 14 days after intervention. At 6 kHz, four rats showed improvement and the rest remained stable. At 8 kHz, four showed improvement, one had deterioration and two remained stable. In the other groups, hearing loss deteriorated in about half of the rats and remained stable in the rest. The mean post-operative 6 kHz threshold was significantly lower than that immediately after the intervention in the study group, contrary to the other groups. The study group had significantly better mean histopathological grading than the other groups.

Conclusion:

Local insulin-like growth factor 1 application may protect hearing after cochlear implantation.

Copyright
Corresponding author
Address for correspondence: Dr Yalcin Alimoglu, Otolaryngology Department, Haseki Training and Research Hospital, Istanbul, Turkey E-mail: alimoglu2001@gmail.com
References
Hide All
1 FI Ahmad , B Choudhury , CE De Mason , OF Adunka , CC Finley , DC. Fitzpatrick Detection of intracochlear damage during cochlear implant electrode insertion using extracochlear measurements in the gerbil. Laryngoscope 2012;122:636–44

2 PA Leake , O Stakhovskaya , A Hetherington , SJ Rebscher , B. Bonham Effects of brain-derived neurotrophic factor (BDNF) and electrical stimulation on survival and function of cochlear spiral ganglion neurons in deafened, developing cats. J Assoc Res Otolaryngol 2013;14:187211

3 H Eastwood , A Chang , G Kel , D Sly , R Richardson , SJ. O'Leary Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea. Hear Res 2010;265:25–9

4 AL. Rosenbloom Mecasermin (recombinant human insulin-like growth factor I). Adv Ther 2009;26:4054

5 T Nakagawa , T Sakamoto , H Hiraumi , YS Kikkawa , N Yamamoto , K Hamaguchi Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC Medicine 2010;8:76

6 ML Carlson , CL Driscoll , RH Gifford , GJ Service , NM Tombers , BJ Hughes-Borst Implications of minimizing trauma during conventional cochlear implantation. Otol Neurotol 2011;32:962–8

7 LP Smith , AA Eshraghi , DE Whitley , TR van de Water , TJ. Balkany Induction of localized cochlear hypothermia. Acta Otolaryngol 2007;127:228–33

9 K Niedermeier , S Braun , C Fauser , J Kiefer , RK Straubinger , T. Stark A safety evaluation of dexamethasone-releasing cochlear implants: comparative study on the risk of otogenic meningitis after implantation. Acta Otolaryngol 2012;132:1252–60

10 S Quesnel , Y Nguyen , P Campo , O Hermine , JA Ribeil , M Elmaleh Protective effect of systemic administration of erythropoietin on auditory brain stem response and compound action potential thresholds in an animal model of cochlear implantation. Ann Otol Rhinol Laryngol 2011;120:737–47

11 KY Lee , T Nakagawa , T Okano , R Hori , K Ono , Y Tabata Novel therapy for hearing loss: delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel. Otol Neurotol 2007;28:976–81

12 AJ Butt , SM Firth , RC. Baxter The IGF axis and programmed cell death. Immunol Cell Biol 1999;77:256–62

14 LM Frago , S Cañón , EJ de la Rosa , Y León , I. Varela-Nieto Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I. J Cell Sci 2003;116:475–86

15 YS Kikkawa , T Nakagawa , L Ying , Y Tabata , Tsubouchi H, Ido A et al. Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis. J Transl Med 2014;12:280

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 2
Total number of PDF views: 39 *
Loading metrics...

Abstract views

Total abstract views: 189 *
Loading metrics...

* Views captured on Cambridge Core between 26th January 2017 - 26th September 2017. This data will be updated every 24 hours.