Skip to main content Accessibility help

The effects of fibrin tissue adhesive on the middle ear

  • D. Katzke (a1), A. Pusalkar (a1) and E. Steinbach (a1)


This study investigated the effects of fibrin glue (‘Tissucol’, Immuno Pty. Ltd.) in the middle and inner ear. Small amounts of the adhesive were used in 36 operations performed on 18 rabbits. The light microscopic examination of these ears four, eight and 12 weeks after surgery showed that the adhesive was well tolerated and that it did not have any toxic effecton on the middle ear or membranous labyrinth. The fibrin tissue adhesive can therefore safely be used to facilitate reconstructive middle-ear surgery and, with the aid of fasic, also for the closure of labyrinthine fistulae; or to achieve a definite seal of the oval window niche after stapes surgery.


Corresponding author

Department of Otorhinolarygology, University of Tabingen, Silcherstr. 5, D-7400 Tübingen, W. Germany.


Hide All
Cronkite, E. P., Lozner, E. L., and Deaver, J. M. (1944) Use of thrombin and fibrinogen in skin grafting. Journal of the American Medical Association, 124: 976.
Gastpar, H. (1977) Tonsillektomie bei blutungsgefährdeten Patienten. Fortschritte der Medizin, 19: 12771280.
Gastpar, H., Kastenbauer, E. R., and Behbehani, A. E. (1979) Erfahrungen mit einem humanen Fibrinkleber bei operativen Eingriffen im Kopf-Hals-Bereich. Laryngologie, Rhinologie and Otologie, 58: 389399.
Heumann, H., and Steinbach, E. (1980) The effects of an adhesive on the middle ear. Archives of Otolaryngology, 106: 734736.
Kastenbauer, E. R. (1973) Die Anwendung des Gewebeklebers Histoaryl bei der Tympanoplastik im Tierexperiment. HNO, 21: 214216.
Kerr, A. G., and Smyth, G. D. L. (1971) Bucrylate as an ossicular adhesive. Archives of Otolaryngology, 94: 129131.
Matras, H., and Kuderna, H. (1975) Glueing nerve anastomosis with clotting substances. II. Clinical Application. Abstract Kongreβ für plastische und rekonstruktive Chirurgie Paris.
McKelvie, P. (1969) A trial of adhesives in reconstructive middle ear surgery. The Journal of Laryngology and Otology, 83: 11051109.
Panis, R., and Rettinger, G. (1979) Verschluβ von kleinen Rezidivperforationen nach Tympanoplastik mit einem Fibrinklebstoff. HNO, 27: 413415.
Staindl, O. (1978) Frontobasale Verletzungen. Richtlinien der operativen Versorgung unter Berücksichtigung hochkonzentrierten humanen Fibrinogens als Gewebekleber. Wien, Medizinische Wochenzeitschrift, 13: 387390.
Steinbach, E. (1980) Experimental studies on cholesteatoma formation. Acta oto-rhino-laryngologica belgica, 34: 5661.
Steinbach, E., and Groninger, G. (1980) Experimental production of cholesteatoma in rabbits by using non-irritants (skin tolerants). The Journal of Laryngology and Otology, 94: 269279.
Straehler-Pohl, H. J., and Koch, U. (1981) Verschluβ von Rezidivperforationen des Trommelfelles mit Cialit-konservierter Fascie und humanem Fibrinkleber, Laryngologie, Rhinologie and Otologie, 60: 109– 112.
Tidrick, R. T., and Warner, E. D. (1944) Fibrin fixation of skin transplants. Surgery, 15: 90.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed