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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Jindal, Aditya Bal, Amanjit and Agarwal, Ritesh 2015. Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group. Journal of Bronchology & Interventional Pulmonology, Vol. 22, Issue. 1, p. 58.

    Kanthan, Rani Senger, Jenna-Lynn and Miller, Grant 2014. Isolated pediatric endobronchial primary anaplastic large cell lymphoma. Journal of Pediatric Surgery Case Reports, Vol. 2, Issue. 2, p. 66.


Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations

  • M Brodlie (a1) (a2), S C Barwick (a1), K M Wood (a3), M C McKean (a1) and A Welch (a4)
  • DOI:
  • Published online: 12 April 2011

To highlight the clinical importance of inflammatory myofibroblastic tumours of the respiratory tract in children, and to present a case series of three children which illustrates this tumour's variable clinical presentation.

Case history:

The series includes: a nine-year-old girl with a diagnosis of juvenile idiopathic arthritis, who presented with finger clubbing and was found to have an inflammatory myofibroblastic tumour in her right upper lobe; a 15-year-old adolescent with a left main stem bronchial inflammatory myofibroblastic tumour, who presented with breathlessness and chest pain; and a 12-year-old girl with a tracheal inflammatory myofibroblastic tumour who presented with stridor. In each case, the tumour was resected surgically.


Inflammatory myofibroblastic tumour are a rare but clinically important and pathologically distinct lesion of the respiratory tract in children. The cases in this series highlight some of the varied clinical presentations of inflammatory myofibroblastic tumours, and illustrate some of this tumour's different anatomical locations within the paediatric respiratory tract.

Corresponding author
Address for correspondence: Dr Malcolm Brodlie, SpR in Respiratory Paediatrics, c/o Paediatric Respiratory Secretaries, Old Children's Outpatients, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE7 7DN, UK Fax: +44 191 233 1417 E-mail:
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1BC Gleason , JL Hornick . Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol 2008;61:428–37

2LP Dehner . Inflammatory myofibroblastic tumor: the continued definition of one type of so-called inflammatory pseudotumor. Am J Surg Pathol 2004;28:1652–4

7JS Janik , JP Janik , MA Lovell , RJ Hendrickson , DD Bensard , BS Greffe . Recurrent inflammatory pseudotumors in children. J Pediatr Surg 2003;38:1491–5

9K Ochs , B Hoksch , U Frey , RA Schmid . Inflammatory myofibroblastic tumor of the lung in a five-year-old girl. Interact Cardiovasc Thorac Surg 2010;10:805–6

10P Rohrlich , M Peuchmaur , SN Cocci , ID Gasselin , C Garel , Y Aigrain Interleukin-6 and interleukin-1 beta production in a pediatric plasma cell granuloma of the lung. Am J Surg Pathol 1995;19:590–5

14CM Coffin , A Patel , S Perkins , KS Elenitoba-Johnson , E Perlman , CA Griffin . ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol 2001;14:569–76

15I Hoseok , H Joungho , KM Ahn , SI Lee , K Jhingook . Complete surgical resection of inflammatory myofibroblastic tumor with carinal reconstruction in a 4-year-old boy. J Pediatr Surg 2005;40:e23–5

16R Przkora , U Bolder , S Schwarz , KW Jauch , J Spes , R Andreesen Regression of nonresectable inflammatory myofibroblastic tumours after treatment with nonsteroidal anti-inflammatory drugs. Eur J Clin Invest 2004;34:320–1

17O Sacco , C Gambini , C Gardella , P Toma , UG Rossi , V Jasonni “Atypical steroid response” in a pulmonary inflammatory myofibroblastic tumor. Pediatr Pulmonol 2010;45:721–6

18RA Morotti , MD Legman , N Kerkar , BR Pawel , WG Sanger , CM Coffin . Pediatric inflammatory myofibroblastic tumor with late metastasis to the lung: case report and review of the literature. Pediatr Dev Pathol 2005;8:224–9

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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