Skip to main content Accessibility help
×
×
Home

Is otosclerosis a generalized connective tissue disorder?: Biophysical and biochemical studies of skin biopsies from patients with otosclerosis

  • H. Oxlund (a1), U. Pedersen (a2), C. C. Danielsen (a1), I. Oxlund (a2) and O. Elbrønd (a2)...

Abstract

It has been suggested that otosclerosis might be caused by a generalized disorder in the connective tissue.

The biophysical and biochemical properties of skin biopsies from twelve patients with otosclerosis and twelve age- and sex-matched controls were investigated. No differences were found in skin strength and extensibility, skin thickness, collagen content, the relationship between collagen type I and type III, reducible collagen cross-links and molecular stability of collagen type I of samples from patients with otosclerosis as compared with those from the controls. The present study does not support the suggestion that otosclerosis might be a generalized connective tissue disorder.

Copyright

Corresponding author

Mr. Hans Oxlund, M.D., Ph.D., Chairman, Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark.

References

Hide All
Altmann, F. and Kornfeld, M. (1967) Osteogenesis imperfecta and otosclerosis: new investigations. Annals of Otology, Rhinology and Laryngology, 76: 89104.
Bailey, A. J., Peach, C. M. and Fowler, J. L. (1970) Chemistry of the collagen cross-links. Isolation and characterization of two intermediate intermolcular cross-links in collagen. Biochemical Journal, 117: 819831.
Bentzen, O. (1961) Skin anomalies in otosclerosis. 7e Congresse Internationale de oto-rhino-laryngologie, Paris. Excerpta Medica International Congress Series, 35: 4041.
Bentzen, O. (1981) Otosklerose—eine Allgemeinerkrankung. HNO Praxis, 6: 411.
Bentzen, O. (1982) Sensorineural hearing loss and somatic insufficiency. Audiology, 21: 97110.
Bretlau, O. and Jørgensen, M. B. (1969) Otosclerosis and osteogenesis imperfecta. Archives of Otolaryngology, 90: 410.
Danielsen, C. C. (1982a) Precision method to determine denaturation temperature of collagen using ultraviolet difference spectroscopy. Collagen Related Research, 2: 143150.
Danielsen, C. C. (1982b) Difference in thermal stability of type-I and type-III collagen from rat skin. Biochemical Journal, 203: 323326.
Hanson, A. N. and Bentley, J. P. (1983) Quantitation of type I to type III collagen ratios in small samples of human tendon, blood vessels and atherosclerotic plaque. Analytical Biochemistry, 130: 3240.
Light, N. D. and Bailey, A. J. (1979) Changes in crosslinking during aging in bovine tendon collagen. Febs letters, 97: 183188.
Oxlund, H., Manthorpe, R. and Viidik, A. (1981) The biomechanical properties of connective tissue in rabbits as influenced by short-term glucocorticoid treatment. Journal of Biomechanics, 14: 129133.
Oxlund, H., Sims, T. and Light, N. D. (1982) Changes in mechanical properties, thermal stability, reducible cross-links and glycosyl-lysines in rat skin induced by corticosteroid treatment. Acta Endocrinologica, 101: 312320.
Oxlund, H., Pedersen, U., Danielsen, C. C., Oxlund, I. and Elbrønd, O. (1985) Reduced strength of skin in osteogenesis imperfecta. European Journal of Clinical Investigation, 15: 408411.
von Pavlov, V., Fitscheva, M. and Zener, I. V. (1981) Befunde an den kollagenen fasern der haut bei otosclerosekranken. HNO Praxis, 6: 1216.
Pedersen, U., Melsen, F., Elbrønd, O. and Charles, P. (1985) Histopathology of the stapes in osteogenesis imperfecta. Journal of Laryngology and Otology, 99: 451458.
Reiser, K. M. and Last, J. A. (1983) Anomalous electrophoretic behavior of a cyanogen bromide peptide from type III collagen. Connective Tissue Research, 12: 116.
Robins, S. P., Shimokomaki, M. and Bailey, A. J. (1973) The chemistry of the collagen cross-links. Age-related changes in the reducible components of intact bovine collagen fibres. Biochemical Journal, 131: 771780.
Sokal, R. R. and Rohlf, J. (1981) Biometry. W H Freeman and Co., San Francisco.
Woessner, J. F. (1976) Determination of hydroxy-proline in connective tissues. In: Hall, D. A. (ed.). The methodology of connective tissue research. Joynson-Bruwers Ltd; Oxford: pp. 227233.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed