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Is otosclerosis a generalized connective tissue disorder?: Biophysical and biochemical studies of skin biopsies from patients with otosclerosis

  • H. Oxlund (a1), U. Pedersen (a2), C. C. Danielsen (a1), I. Oxlund (a2) and O. Elbrønd (a2)...


It has been suggested that otosclerosis might be caused by a generalized disorder in the connective tissue.

The biophysical and biochemical properties of skin biopsies from twelve patients with otosclerosis and twelve age- and sex-matched controls were investigated. No differences were found in skin strength and extensibility, skin thickness, collagen content, the relationship between collagen type I and type III, reducible collagen cross-links and molecular stability of collagen type I of samples from patients with otosclerosis as compared with those from the controls. The present study does not support the suggestion that otosclerosis might be a generalized connective tissue disorder.


Corresponding author

Mr. Hans Oxlund, M.D., Ph.D., Chairman, Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark.


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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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