Skip to main content

Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis

  • E Sahin (a1), D Dizdar (a2), M E Dinc (a3) and A A Cirik (a4)
Abstract Background:

Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis.


The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients).


The symptom scores before allergen-specific immunotherapy were significantly higher than those obtained after 3 years of allergen-specific immunotherapy and 10 years after allergen-specific immunotherapy (p < 0.0175). There were no significant differences between the scores obtained at 3 years and 10 years after allergen-specific immunotherapy (p > 0.0175).


Subcutaneous immunotherapy is an effective treatment for house dust mite induced allergic rhinitis.

Corresponding author
Address for correspondence: Dr Denizhan Dizdar, Department of Otorhinolaryngology, Medical Park Bahçelievler Hospital, Faculty of Medicine, Istanbul Kemerburgaz University, Istanbul, Turkey E-mail:
Hide All
1 Platts-Mills TA, Erwin EA, Heymann PW, Woodfolk JA. Pro: the evidence for a causal role of dust mites in asthma. Am J Respir Crit Care Med 2009;180:109–13
2 Sporik R, Chapman MD, Platts-Mills TA. House dust mite exposure as a cause of asthma. Clin Exp Allergy 1992;22:897906
3 Eifan AO, Calderon MA, Durham SR. Allergen immunotherapy for house dust mite: clinical efficacy and immunological mechanisms in allergic rhinitis and asthma. Expert Opin Biol Ther 2013;13:1543–56
4 Masoli M, Fabian D, Holt S, Beasley R; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469–78
5 Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J 2015;46:622–39
6 Canonica GW, Bousquet J, Mullol J, Scadding GK, Virchow JC. A survey of the burden of allergic rhinitis in Europe. Allergy 2007;62:1725
7 Bahceciler NN, Cobanoglu N. Subcutaneous versus sublingual immunotherapy for allergic rhinitis and/or asthma. Immunotherapy 2011;3:747–56
8 Pevec B, Pevec MR, Markovic AS, Batista I. House dust mite subcutaneous immunotherapy does not induce new sensitization to tropomyosin: does it do the opposite? J Investig Allergol Clin Immunol 2014;24:2934
9 Sahin E, Taş E, Dağtekin Ergür EN, Cuhali BD, Gürsel AO. The results of specific immunotherapy for house dust mites in patients with allergic rhinitis [in Turkish]. Kulak Burun Bogaz Ihtis Derg 2008;18:7984
10 Şahin E. Comparison of 3-year Clınıcal and Laboratory Results for Dermatophagoides Pteronyssinus and Dermatophagoides Farinae Allergen Specific Immunotherapy, Specialization Thesis [in Turkish]. Istanbul: Turkish Ministry of Health, Bakırkoy Education and Research Hospital, 2005
11 Cingi C, Bayar Muluk N, Ulusoy S, Acar M, Şirin S, Çobanoğlu B et al. Efficacy of sublingual immunotherapy for house dust mite allergic rhinitis. Eur Arch Otorhinolaryngol 2015;272:3341–6
12 Lachapelle JM, Maibach HI. Patch Testing and Prick Testing: A Practical Guide, 2nd edn. Berlin/Heidelberg: Springer Verlag, 2009
13 Aricigil M, Muluk NB, Sakarya EU, Sakalar EG, Senturk M, Reisacher W et al. New routes of allergen immunotherapy. Am J Rhinol Allergy 2016;30:193–7
14 Kavut AB, Kalpaklıoğlu F. Diagnostic tools for allergic rhinitis and asthma. J Med Updates 2012;2:2230
15 Yaz A, Cingi C, Gürbüz MK, Bal C. The long-term results of the impact of rhinophototherapy on quality of life in cases with allergic rhinitis. J Med Updates 2012;2:63–9
16 Ying S, Barata LT, Meng Q, Grant JA, Barkans J, Durham SR et al. High-affinity immunoglobulin E receptor (Fc epsilon RI)-bearing eosinophils, mast cells, macrophages and Langerhans' cells in allergen-induced late-phase cutaneous reactions in atopic subjects. Immunology 1998;93:281–8
17 Gaga M, Frew AJ, Varney VA, Kay AB. Eosinophil activation and T lymphocyte infiltration in allergen-induced late phase skin reactions and classical delayed-type hypersensitivity. J Immunol 1991;147:816–22
18 Garcia BE, Sanz ML, Gato JJ, Fernandez J, Oehling A. IgG4 blocking effect on the release of antigen-specific histamine. J Investig Allergol Clin Immunol 1993;3:2633
19 Iliopoulos O, Baroody FM, Naclerio RM, Bochner BS, Kagey-Sobotka A, Lichtenstein LM. Histamine-containing cells obtained from the nose hours after antigen challenge have functional and phenotypic characteristics of basophils. J Immunol 1992;148:2223–8
20 Sampson AP. The role of eosinophils and neutrophils in inflammation. Clin Exp Allergy 2000;1:22–7
21 Creticos PS, Esch RE, Couroux P, Gentile D, D'Angelo P, Whitlow B et al. Randomized, double-blind, placebo controlled trial of standardized ragweed sublingual-liquid immunotherapy for allergic rhinoconjunctivitis. J Allergy Clin Immunol 2014;133:751–8
22 Pevec B, Radulovic Pevec M, Stipic Markovic A, Batista I, Rijavec M, Silar M et al. House dust mite specific immunotherapy alters the basal expression of T regulatory and FcεRI pathway genes. Int Arch Allergy Immunol 2012;159:287–96
23 Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken S, Høst A et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy 2007;62:943–8
24 Bousquet J, Lockey R, Malling HJ, Alvarez-Cuesta E, Canonica GW, Chapman MD et al. Allergen immunotherapy: therapeutic vaccines for allergic diseases. World Health Organization. American Academy of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol 1998;81:401–5
25 Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Allergen immunotherapy: a practice parameter second update. J Allergy Clin Immunol 2007;120(3 suppl):S2585
26 Li JT, Bernstein DI, Calderon MA, Casale TB, Cox L, Passalacqua G et al. Sublingual grass and ragweed immunotherapy: clinical considerations--a PRACTALL consensus report. J Allergy Clin Immunol 2016;137:369–76
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Altmetric attention score

Full text views

Total number of HTML views: 6
Total number of PDF views: 36 *
Loading metrics...

Abstract views

Total abstract views: 216 *
Loading metrics...

* Views captured on Cambridge Core between 17th October 2017 - 15th December 2017. This data will be updated every 24 hours.