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Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis

  • E Sahin (a1), D Dizdar (a2), M E Dinc (a3) and A A Cirik (a4)

Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis.


The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients).


The symptom scores before allergen-specific immunotherapy were significantly higher than those obtained after 3 years of allergen-specific immunotherapy and 10 years after allergen-specific immunotherapy (p < 0.0175). There were no significant differences between the scores obtained at 3 years and 10 years after allergen-specific immunotherapy (p > 0.0175).


Subcutaneous immunotherapy is an effective treatment for house dust mite induced allergic rhinitis.

Corresponding author
Address for correspondence: Dr Denizhan Dizdar, Department of Otorhinolaryngology, Medical Park Bahçelievler Hospital, Faculty of Medicine, Istanbul Kemerburgaz University, Istanbul, Turkey E-mail:
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  • EISSN: 1748-5460
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