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Reduction of blood eosinophil counts in eosinophilic chronic rhinosinusitis after surgery

  • A Honma (a1), D Takagi (a1), Y Nakamaru (a1), A Homma (a1), M Suzuki (a1) and S Fukuda (a1)...
Abstract
Objective:

This study aimed to predict eosinophilic chronic rhinosinusitis prognosis by investigating changes in the blood eosinophil count and other disease biomarkers after surgery.

Methods:

Blood eosinophil numbers and serum interleukin-5 levels were measured in 22 eosinophilic chronic rhinosinusitis patients before and after functional endoscopic sinus surgery, and compared with equivalent measures in non-eosinophilic chronic rhinosinusitis patients and chronic rhinosinusitis without polyps patients. Differences between well-controlled eosinophilic chronic rhinosinusitis patients and those who experienced recurrence were also assessed.

Results:

Blood eosinophil numbers and serum interleukin-5 level decreased after surgery in eosinophilic chronic rhinosinusitis patients. In this patient group, blood eosinophil counts before surgery were significantly higher in patients who experienced recurrence (825.7 ± 26.1 vs 443.9 ± 76.6 cells/μl, p < 0.05), and decreased significantly after surgery (825.7 ± 26.1 vs 76.7 ± 25.8 cells/μl, p < 0.05).

Conclusion:

Blood eosinophil numbers may reflect disease severity in eosinophilic chronic rhinosinusitis patients and their prognosis after surgery.

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Copyright
Corresponding author
Address for correspondence: Dr D Takagi, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan Fax: +81 11 717 7566 E-mail: daitamed@huhp.hokudai.ac.jp
References
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
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