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    Lepera, Davide Volpi, Luca Facco, Carla Turri-Zanoni, Mario Battaglia, Paolo Bernasconi, Barbara Piski, Zalán Freguia, Stefania Castelnuovo, Paolo and Bignami, Maurizio 2016. Endoscopic Treatment of Ewing Sarcoma of the Sinonasal Tract. Journal of Craniofacial Surgery, Vol. 27, Issue. 4, p. 1001.


    López, Fernando Devaney, Kenneth O. Hanna, Ehab Y. Rinaldo, Alessandra Ferlito, Alfio and Eisele, David W. 2016. Metastases to nasal cavity and paranasal sinuses. Head & Neck,


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Solitary extra-skeletal sinonasal metastasis from a primary skeletal Ewing's sarcoma

  • S M Hayes (a1), T N Jani (a2), S M Rahman (a2), S Jogai (a3), P G Harries (a1) and R J Salib (a1)
  • DOI: http://dx.doi.org/10.1017/S0022215111000764
  • Published online: 18 May 2011
Abstract
AbstractIntroduction:

Ewing's sarcoma is a rare, malignant tumour predominantly affecting young adolescent males. We describe a unique case of an isolated extra-skeletal metastasis from a skeletal Ewing's sarcoma primary, arising in the right sinonasal cavity of a young man who presented with severe epistaxis and periorbital cellulitis.

Results:

Histologically, the lesion comprised closely packed, slightly diffuse, atypical cells with round, hyperchromatic nuclei, scant cytoplasm and occasional mitotic figures, arranged in a sheet-like pattern. Immunohistochemical analysis showed positive staining only for cluster of differentiation 99 glycoprotein. Fluorescent in situ hybridisation identified the Ewing's sarcoma gene, confirming the diagnosis.

Management:

Complete surgical resection was achieved via a minimally invasive endoscopic transnasal approach; post-operative radiotherapy. Ten months post-operatively, there were no endoscopic or radiological signs of disease.

Conclusion:

Metastatic Ewing's sarcoma within the head and neck is incredibly rare and can pose significant diagnostic and therapeutic challenges. An awareness of different clinical presentations and distinct histopathological features is important to enable early diagnosis. This case illustrates one potential management strategy, and reinforces the evolving role of endoscopic transnasal approaches in managing sinonasal cavity and anterior skull base tumours.

Copyright
Corresponding author
Address for correspondence: Mr Stephen Hayes, c/o ENT Department, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK Fax: +44 (0)238 079 4868 E-mail: drhayes@doctors.net.uk
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18S Yalcin , HT Turoglu , S Ozdamar . Ewing's tumor of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1993;76:362–7

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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