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Tracheopathia chondro-osteoplastica – an unusual cause of stridor

  • R S Natt (a1), T Helliwell (a2) and M McCormick (a1)

Abstract

Objectives:

A case of tracheopathia chondro-osteoplastica causing sub-glottic stenosis is described.

Study design:

Case report and literature review.

Materials and methods:

A 37-year-old man presented with a 15-year history of gradually worsening dyspnoea and stridor due to sub-glottic stenosis. His medical and radiographic records were reviewed. This patient's presentation, histopathological findings and radiology images are presented and discussed.

Results:

Histopathological evaluation of microlaryngoscopy biopsy specimens, taken during laser debulking of the stenosis, confirmed the presence of tracheopathia chondro-osteoplastica.

Conclusions:

This is the first reported case of sub-glottic stenosis caused by tracheopathia chondro-osteoplastica which required an urgent tracheostomy.

Copyright

Corresponding author

Address for correspondence: Mr R S Natt, Department of Ear, Nose and Throat, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. E-mail: ravindernatt@hotmail.com

Footnotes

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Presented at the North of England Otolaryngology Society Meeting, Royal Liverpool Children's NHS Trust, Alder Hey Hospital, Liverpool, March 2008.

Footnotes

References

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2 Park, SS, Shin, DH, Lee, DH, Jeon, SC, Lee, JD. Tracheopathia osteoplastica simulating asthmatic symptoms. Diagnosis by bronchoscopy and computerised tomography. Respiration 1995;62:43–5
3 Prakash, UB, McCullough, AE, Edell, ES, Nienhuis, DM. Tracheopathia osteoplastica: familial occurrence. Mayo Clin Proc 1989;64:1091–6
4 Hayes, D Jr. Tracheopathia osteoplastica misdiagnosed as asthma. J Asthma 2007;44:253–5
5 Virchow, R. Krankafte Geschwulsten [in German]. Berlin: Hirschwald, 1863
6 Aschoff, L. Uber tracheopathia osteoplastica [in German]. Verch Dtsch Path Ges 1910;14:125–7
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9 Harma, RA, Suurkari, S. Tracheopathia chondro-osteoplastica: a clinical study of 30 cases. Acta Otolaryngol 1977;84:118–23
10 Tajima, K, Yamakawa, M, Katagiri, T, Sasaki, H. Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica. Virchows Arch 1997;431:359–63
11 Meyer, CN, Dossing, M, Broholm, H. Tracheobronchiopathia osteochondroplastica. Respir Med 1997;91:499502
12 Clee, MD, Anderson, JM, Johnston, RN. Clinical aspects of tracheobronchopathia osteochondroplastica. Br J Dis Chest 1983;77:308–13
13 Bottles, K, Nyberg, DA, Clark, M, Hinchcliffe, WA. CT diagnosis of tracheobronchopathia osteochondroplastica. J Comput Assist Tomogr 1983;7:324–7
14 Onitsuka, H, Hirose, N, Watanabe, K, Nishitani, H, Kawahira, K, Matsuura, K et al. Computed tomography of tracheopathia osteoplastica. Am J Roentgenol 1983;140:268–70
15 Pounder, DJ, Pieterse, AS. Tracheopathia osteoplastica: a study of the minimal lesion. J Pathol 1982;138:235–9
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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