Skip to main content Accessibility help
×
Home

Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial

  • A Thakur (a1), S Gupta (a2), J S Thakur (a2), R S Minhas (a2), R K Azad (a2), M S Vasanthalakshmi (a3), D R Sharma (a1) and N K Mohindroo (a2)...

Abstract

Objective

To assess the effect of tranexamic acid in head and neck surgical procedures.

Methods

A prospective, double-blind and randomised, parallel group, placebo-controlled clinical trial was conducted. Ninety-two patients undergoing various head and neck surgical procedures were randomised. Subjects received seven infusions of coded drugs (tranexamic acid or normal saline) starting at the time of skin closure. Haematological, biochemical, blood loss and other parameters were observed by the staff, who were blinded to patients’ group allocation (case or control).

Results

Patients were analysed on the basis of type of surgery. Fifty patients who had undergone surgical procedures, including total thyroidectomy, total parotidectomy, and various neck dissections with or without primary tumour excision, were included in the first group. The second group comprised 41 patients who had undergone hemithyroidectomy, lobectomy or superficial parotidectomy. There was no statistical difference in blood parameters between both groups. There was a reduction in post-operative drain volume, but this was not significant.

Conclusion

Although this prospective, randomised, placebo-controlled clinical trial found a reduction in post-operative drain volume in tranexamic acid groups, the difference was not statistically significant between the various head and neck surgical procedure groups.

Copyright

Corresponding author

Author for correspondence: Dr Jagdeep S Thakur, Dept of Otolaryngology – Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India E-mail: anujagdeep@yahoo.co.in

Footnotes

Hide All

Dr J S Thakur takes responsibility for the integrity of the content of the paper

Footnotes

References

Hide All
1Williams, J, Toews, D, Prince, M. Survey of the use of suction drains in head and neck surgery and analysis of their biomechanical properties. J Otolaryngol 2003;32:1622
2Urquhart, AC, Berg, RL. Neck dissections: predicting postoperative drainage. Laryngoscope 2002;112:1294–8
3Vilar-Compte, D, Jacquemin, B, Robles-Vidal, C, Volkow, P. Surgical site infections in breast surgery: case-control study. World J Surg 2004;28:242–6
4Ersoy, YE, Aysan, E, Meric, A, Kadioglu, H, Cengiz, MB, Bozkurt, S et al. Does adrenaline spraying over thyroidectomy area reduce bleeding? Int J Clin Exp Med 2014;7:274–9
5Tartaglia, N, Di Lascia, A, Lizzi, V, Cianci, P, Fersini, A, Ambrosi, A et al. Haemostasis in thyroid surgery: collagen-fibrinogen-thrombin patch versus cellulose gauze--our experience. Surg Res Pract 2016;2016:3058754
6Dunn, CJ, Goa, KL. Tranexamic acid: a review of its use in surgery and other indications. Drugs 1999;57:1005–32
7Gohel, M, Patel, P, Gupta, A, Desai, P. Efficacy of tranexamic acid in decreasing blood loss during and after caesarean section: a randomized case controlled prospective study. J Obstet Gynecol 2007;57:227–30
8Chen, CC, Wang, CC, Wang, CP, Lin, TH, Lin, WD, Liu, SA. Prospective, randomized, controlled trial of tranexamic acid in patients who undergo head and neck procedures. Otolaryngol Head Neck Surg 2008;138:762–7
9Kulkarni, AP, Chaukar, DA, Patil, VP, Metgudmath, RB, Hawaldar, RW, Divatia, JV. Does tranexamic acid reduce blood loss during head and neck cancer surgery? Indian J Anaesth 2016;60:1924
10Das, A, Chattopadhyay, S, Mandal, D, Chhaule, S, Mitra, T, Mukherjee, A et al. Does the preoperative administration of tranexamic acid reduce perioperative blood loss and transfusion requirements after head neck cancer surgery? A randomized, controlled trial. Anesth Essays Res 2015;9:384–90
11Dollery, C. Therapeutic Drugs, 2nd edn. New York: Churchill Livingstone, 1998;T150–2
12Poeran, J, Rasul, R, Suzuki, S, Danninger, T, Mazumdar, M, Opperer, M et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ 2014;349:g4829
13Gandhi, R, Evans, HM, Mahomed, SR, Mahomed, NN. Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis. BMC Res Notes 2013;6:184
14Ker, K, Roberts, I. Exploring redundant research into the effect of tranexamic acid on surgical bleeding: further analysis of a systematic review of randomised controlled trials. BMJ Open 2015;5:e009460
15Karimi, A, Mohammadi, SS, Hasheminasab, M. Efficacy of tranexamic acid on blood loss during bimaxillary osteotomy: a randomized double blind clinical trial. Saudi J Anaesth 2012;6:41–5
16Eldaba, AA, Amr, YM, Albirmawy, OA. Effects of tranexamic acid during endoscopic sinus surgery in children. Saudi J Anaesth 2013;7:229–33

Keywords

Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial

  • A Thakur (a1), S Gupta (a2), J S Thakur (a2), R S Minhas (a2), R K Azad (a2), M S Vasanthalakshmi (a3), D R Sharma (a1) and N K Mohindroo (a2)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed