Skip to main content Accessibility help

Treatment of perennial allergic rhinitis by sodium cromoglycate plus 0.025 per cent xylometazoline: (a double-blind study)

  • M. Fradis (a1), L. Podoshin (a1) and R. Gertner (a1)


The object of this double-blind study was to assess the therapeutic effects of a combination of two per cent sodium cromoglycate and 0.025 per cent xylometazoline compared with a matched placebo. Forty patients were included in the two-week study.

The treatment was found to be rapidly effective taking only a day to control symptoms in almost 80 per cent of the patients in the group receiving active treatment.

No evidence of rebound effects due to the decongestant was observed during the study.


Corresponding author

Professor L. Podoshin, M.D., Haifa Medical Center (Rothschild), Department of Otolaryngology, P.O. Box 4940, Haifa 31 048, Israel.


Hide All
Bende, M., Andersson, K. E., Johannsson, C-J.Sjogren, G. and Svensson, G. (1984) Dose response relationship of a topical nasal decongestant: phenylpropanolamine. Acta Otolaryngologica, 98: 543547.
Frostad, A. B. (1977) The treatment of seasonal allergic rhinitis with 2% aqueous solution of sodium cromoglycate delivered by a metered dose nasal spray. Clinical Allergy, 7: 347353.
Gertner, R., Podoshin, L. and Fradis, M. (1984) A simple method of measuring the nasal airway in clinical work. Journal of Laryngology and Otology, 48: 351355.
Hamilton, L. H. (1981) Effect of xylometasoline nasal spray on nasal conductance in subjects with coryza. Journal of Otolaryngology, 10(2): 109116.
Kluger, H. A. (1959) Beitrag zur behandlung akuter und rezidivierender schwellingszustande der vasenschleimhaut. Medizinische Welt, 40: 18751878.
Konno, A., Togawa, K. and Nishihira, Sh. (1982) Participation of vascular reflex in mucosal swelling in nasal allergy. Acta Otolaryngologica, 94: 131140.
Lobaton, P., Seranno, V., Rubio, N. and Gomerz, D. (1975) Treatment of perennial rhinitis with 2% solution of sodium cromoglycate, Rhinology, 13: 9197.
Mygind, N. (1973) Local effect of intra-nasal beclomethasone dipropionate aerosol in hay fever. British Medical Journal, i: 464469.
Petruson, B. (1981) Treatment with xylometazoline (Otrivin) nosedrops over a six week period. Rhinology, 19: 167172.
Wihl, J. A. (1979) Immunotherapy indications and contraindications. Acta Otolaryngologica, Supplement, 360: 1220.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed