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Variable expression of molecular markers in juvenile nasopharyngeal angiofibroma

  • A Mishra (a1), A Pandey (a2) and S C Mishra (a3)
Abstract
Abstract Background:

Molecular categorisation may explain the wide variation in the clinical characteristics of juvenile nasopharyngeal angiofibroma.

Methods:

Variations in molecular markers in juvenile nasopharyngeal angiofibroma in an Indian population were investigated and compared with global reports.

Results:

Variable molecular marker expression was demonstrated at the regional and global levels. A wide variation in molecular characteristics is evident. Molecular data have been reported for only 11 countries, indicating a clear geographical bias. Only 58 markers have been studied, and most are yet to be validated.

Conclusion:

Research into the molecular epidemiology of juvenile nasopharyngeal angiofibroma is still in its infancy. Although the molecular variation is not well understood, data obtained so far have prompted important research questions. Hence, multicentre collaborative molecular studies are needed to establish the aetiopathogenesis and establish molecular surrogates for clinical characteristics.

Copyright
Corresponding author
Address for correspondence: Dr A Mishra, A-1/19, Sector H Aliganj, Lucknow, Uttar Pradesh, India E-mail: amishra_ent@yahoo.com
Footnotes
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This review is based PhD work of Dr Anupam Mishra.

Footnotes
References
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1 Mishra A, Mishra SC. Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow India. J Laryngol Otol 2016;130:363–8
2 Chew CT. Nasopharynx (the postnasal space). In: Kerr AG, Groves J, eds. Scott-Brown's Otolaryngology: Rhinology V. 4, 5th edn. London: Butterworth, 1987
3 Pandey P, Mishra A, Tripathi AM, Verma V, Trivedi R, Singh HP et al. Current molecular profile of juvenile nasopharyngeal angiofibroma: first comprehensive study from India. Laryngoscope 2016;3:E1006
4 Mishra A, Singh V, Verma V, Pandey S, Trivedi R, Singh HP et al. Current status and clinical correlation of beta-catenin in juvenile nasopharyngeal Angiofibroma. J Laryngol Otol 2016;30:17
5 Boghani Z, Husain Q, Kanumuri VV, Khan MN, Sangvhi S, Liu JK et al. Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. Laryngoscope 2013;123:859–69
6 Saylam G, Yucel OT, Sungur A, Onerci M. Proliferation, angiogenesis and hormonal markers in juvenile nasopharyngeal angiofibroma. Int J Pediatr Otorhinolaryngol 2006;70:227–34
7 Brentani MM, Butugan O, Oshima CTF, Torloni H, Paiva LJ. Multiple steroid receptors in nasopharyngeal angiofibromas. Laryngoscope 1989;99:398401
8 Johns ME, MacLeod RM, Cantrell RW. Estrogen receptors in nasopharyngeal angiofibromas. Laryngoscope 1980;90:628–34
9 Lee DA, Rao BR, Meyer JS, Prioleau PG, Bauer WC. Hormonal receptor determination in juvenile nasopharyngeal angiofibromas. Cancer 1980;46:547–51
10 Hwang HC, Mills SE, Patterson K, Gown AM. Expression of androgen receptors in nasopharyngeal angiofibroma: an immunohistochemical study of 24 cases. Mod Pathol 1998;11:1122–6
11 Farag MM, Ghanimah SE, Ragaie A, Saleem TH. Hormonal receptors in juvenile nasopharyngeal angiofibroma. Laryngoscope 1987;97:208–11
12 Antonelli AR, Cappiello J, Donajo CA, Di Lorenzo D, Nicolai P, Orlandini A. Diagnosis, staging and treatment of juvenile nasopharyngeal angiofibroma (JNA). Laryngoscope 1987;97:1319–25
13 Gatalica Z. Immunohistochemical analysis of steroid hormone receptors in nasopharyngeal angiofibromas. Cancer Lett 1998;127:8993
14 Liu Z, Wang J, Wang H, Wang D, Hu L, Liu Q et al. Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma. Acta Otolaryngol 2015;135:51–7
15 Montag AG, Tretiakova M, Richardson M. Steroid hormone receptor expression in nasopharyngeal angiofibromas. Consistent expression of estrogen receptor beta. Am J Clin Pathol 2006;125:832–7
16 Brieger J, Wierzbicka M, Sokolov M, Roth Y, Szyfter W, Mann WJ. Vessel density, proliferation and immunolocalization of vascular endothelial growth factor in juvenile nasopharyngeal angiofibromas. Arch Otolaryngol Head Neck Surg 2004;130:727–31
17 Zhang M, Sun X, Yu H, Hu L, Wang D. Biological distinctions between juvenile nasopharyngeal angiofibroma and vascular malformation: an immunohistochemical study. Acta Histochem 2011;113:626–30
18 Nonogaki S, Campos HG, Butugan O, Soares FA, Mangone FR, Torloni H et al. Markers of vascular differentiation, proliferation and tissue remodelling in juvenile nasopharyngeal angiofibromas. Exp Ther Med 2010;1:921–6
19 Ponti G, Losi L, Pellacani G, Rossi GB, Presutti L, Mattioli F et al. Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA). Appl Immunohistochem Mol Morphol 2008;16:173–8
20 Schuon R, Brieger J, Heinrich UR, Roth Y, Szyfter W, Mann WJ. Immunohistochemical analysis of growth mechanisms in juvenile angiofibroma. Eur Arch Otorhinolaryngol 2007;264:389–94
21 Schiff M, Gonzalez A, Ong M, Baird A. Juvenile nasopharyngeal angiofibroma contain an angiogenic growth factor: basic FGF. Laryngoscope 1992;102:940–5
22 Silveira SM, Custódio Domingues MA, Butugan O, Brentani MM, Rogatto SR. Tumor microenvironmental genomic alterations in juvenile nasopharyngeal angiofibroma. Head Neck 2012;34:485–92
23 Nagai MA, Butugan O, Logullo A, Brentani MM. Expression of growth factors, protooncogenes and p53 in nasopharyngeal angiofibromas. Laryngoscope 1996;106:190–5
24 Schick B, Wemmert S, Jung V, Steuder W, Montenarh M, Urbschat S. Genetic heterogeneity of MYC oncogene in advanced juvenile angiofibromas. Cancer Genet Cytogenet 2006;164:2531
25 Zhang PJ, Weber R, Liang H, Pasha TL, LiVolsi VA. Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps. Arch Pathol Lab Med 2003;127:1480–4
26 Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S et al. Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology 2008;40:396400
27 Dillard DG, Cohen C, Muller S, Del Gaudio J, Reichman O, Parrish B et al. Immunolocalization of activated transforming growth factor beta1 in juvenile nasopharyngeal angiofibroma. Arch Otolaryngol Head Neck Surg 2000;126:723–5
28 Rippel C, Plinkert PK, Schick B. Expression of members of the cadherin-/catenin-protein family in juvenile angiofibromas [in German]. Laryngorhinootologie 2003;82:353–7
29 Abraham SC, Montgomery EA, Giardiello FM, Wu TT. Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. Am J Pathol 2001;158:1073–8
30 Schick B, Veldung B, Wemmert S, Jung V, Montenarh M, Meese E et al. p53 and Her-2/neu in juvenile angiofibromas. Oncol Rep 2005;13:453–7
31 Coutinho-Camillo CM, Brentani MM, Butugan O, Torloni H, Nagai MA. Relaxation of imprinting of IGFII gene in juvenile nasopharyngeal angiofibromas. Diagn Mol Pathol 2003;12:5762
32 Maniglia MP, Ribeiro ME, Costa NM, Jacomini ML, Carvalho TB, Molina FD et al. Molecular pathogenesis of juvenile nasopharyngeal angiofibroma in Brazilian patients. Pediatr Hematol Oncol 2013;30:616–22
33 Gautham K, Ogale SB, Shraddha RU, Ajay D. Expression of GSTM1 in angiofibromas. J Laryngol Otol 2002;116:352–4
34 Krstulja M, Car A, Bonifacić D, Braut T, Kujundzić M. Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma). Med Hypotheses 2008;70:600–4
35 Wendler O, Schäfer R, Schick B. Mast cells and T-lymphocytes in juvenile angiofibromas. Eur Arch Otorhinolaryngol 2007;264:769–75
36 Schick B, Wemmert S, Bechtel U, Nicolai P, Hofmann T, Golabek W et al. Comprehensive genomic analysis identifies MDM2 and AURKA as novel amplified genes in juvenile angiofibromas. Head Neck 2007;29:479–87
37 Renkonen S, Häyry V, Heikkilä P, Leivo I, Haglund C, Mäkitie AA et al. Stem cell-related proteins C-KIT, C-MYC and BMI-1 in juvenile nasopharyngeal angiofibroma – do they have a role? Virchows Arch 2011;458:189–95
38 Coutinho CM, Bassini AS, Gutiérrez LG, Butugan O, Kowalski LP, Brentani MM et al. Genetic alterations in Ki-ras and Ha-ras genes in juvenile nasopharyngeal angiofibromas and head and neck cancer. Sao Paulo Med J 1999;117:113–20
39 Renkonen S, Heikkilä P, Haglund C, Mäkitie AA, Hagström J. Tenascin-C. GLUT-1, and syndecan-2 expression in juvenile nasopharyngeal angiofibroma: correlations to vessel density and tumor stage. Head Neck 2013;35:1036–42
40 Wang JJ, Sun XC, Hu L, Liu ZF, Yu HP, Li H et al. Endoglin (CD105) expression on microvessel endothelial cells in juvenile nasopharyngeal angiofibroma: tissue microarray analysis and association with prognostic significance. Head Neck 2013;35:1719–25
41 Duerr S, Wendler O, Aigner T, Karosi S, Schick B. Metalloproteinases in juvenile angiofibroma – a collagen rich tumor. Hum Pathol 2008;39:259–68
42 Sun X, Guo L, Wang J, Wang H, Liu Z, Liu J et al. Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma: tissue microarray analysis. Int J Pediatr Otorhinolaryngol 2014:78:1232–8
43 Sun X, Guo L Wang H, Yu H, Wang J, Meng X et al. The presence of tumor-infiltrating IL-17-producing cells in juvenile nasopharyngeal angiofibroma tumor microenvironment is a poor prognostic factor. Am J Otolaryngol 2014:35:582–8
44 Renkonen S, Cardell LO, Mattila P, Lundberg M, Haglund C, Hagström J et al. Toll-like receptors 3, 7, and 9 in juvenile nasopharyngeal angiofibroma. APMIS 2015;123:439–44
45 Schiff M. Juvenile nasopharyngeal angiofibroma. Laryngoscope 1959;69:9811016.
46 Martin H, Ehrlich HE, Abels JC. Juvenile nasopharyngeal angiofibroma. Ann Surg 1948;127:513–36
47 Johnsen S, Kloster JH, Schiff M. The action of hormones on juvenile nasopharyngeal angiofibroma. Acta Otolaryngol 1966;61:153–60
48 Kumagami H. Testosterone and estradiol in juvenile nasopharyngeal angiofibroma tissue. Acta Otolaryngol 1991;111:569–73
49 Kumagami H. Sex hormones in juvenile nasopharyngeal angiofibroma tissue. Auris Nasus Larynx 1993;20:131–5
50 Riggs S, Orlandi RR. Juvenile nasopharyngeal angiofibroma recurrence associated with exogenous testosterone therapy. Head Neck 2010;32:812–15
51 Kuttner K, Katekamp D, Stiller D. Hormone therapy of the juvenile angiofibroma. Arch Otorhinolaryngol 1977;214:331–8
52 Arbiser ZK, Arbiser JL, Cohen C, Gal AA. Neuroendocrine lung tumors: grade correlates with proliferation but not angiogenesis. Mod Pathol 2001;14:1195–9
53 Juric G, Zarkovic N, Nola M, Tillian M, Jukić S. The value of cell proliferation and angiogenesis in the prognostic assessment of ovarian granulosa cell tumors. Tumori 2001;87:4753
54 Haggstrom S, Lissbrant IF, Bergh A, Damber JE. Testosterone induces vascular endothelial growth factor synthesis in the ventral prostate in castrated rats. J Urol 1999;161:1620–5
55 Russell PJ, Bennett S, Stricker P. Growth factor involvement in progression of prostate cancer. Clin Chem 1998;44:705–23
56 Kimbro KS, Simons JW. Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer 2006;13:739–49
57 Pelengaris S, Khan M, Evan G. c-MYC: more than just a matter of life and death. Nat Rev Cancer 2002;2:764–6
58 Liu J, Levens D. Making myc. Curr Top Microbiol Immunol 2006;302:132
59 Levens D. Disentangling the MYC web. Proc Natl Acad Sci U S A 2002;99:5757–9
60 Amir AL, Barua M, McKnight NC, Cheng S, Yuan X, Balk SP. A direct b-catenin independent interaction between androgen receptor and T cell factor. J Biol Chem 2003;278:30828–34
61 Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S et al. Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology 2008;40:396400
62 Barbacid M. Ras genes. Annu Rev Biochem 1987;56:779827
63 Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682–9
64 Valanzano R, Curia MC, Aceto G, Veschi S, De Lellis L, Catalano T et al. Genetic evidence that juvenile nasopharyngeal angiofibroma is an integral FAP tumour. Gut 2005;54:1046–7
65 Klockars T, Renkonen S, Leivo I, Hagström J, Mäkitie AA. Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis. Fam Cancer 2010;9:401–3
66 Schick B, Brunner C, Praetorius M, Plinkert PK, Urbschat S. First evidence of genetic imbalances in angiofibromas. Laryngoscope 2002;112:397401
67 Mohr LC, Rodgers JK, Silvestri GA. Glutathione S-transferase M1 polymorphism and the risk of lung cancer. Anticancer Res 2003;23:2111–24
68 Smith MR, Kantoff PW. Molecular biology of prostate cancer. In: Mendelsohn AC, Howley A, Israel SJ, Liotta L, eds. The Molecular Basis of Cancer, 2nd edn. Philadelphia: WB Saunders, 2001:723–5
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