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Variable expression of molecular markers in juvenile nasopharyngeal angiofibroma

  • A Mishra (a1), A Pandey (a2) and S C Mishra (a3)
Abstract
Abstract Background:

Molecular categorisation may explain the wide variation in the clinical characteristics of juvenile nasopharyngeal angiofibroma.

Methods:

Variations in molecular markers in juvenile nasopharyngeal angiofibroma in an Indian population were investigated and compared with global reports.

Results:

Variable molecular marker expression was demonstrated at the regional and global levels. A wide variation in molecular characteristics is evident. Molecular data have been reported for only 11 countries, indicating a clear geographical bias. Only 58 markers have been studied, and most are yet to be validated.

Conclusion:

Research into the molecular epidemiology of juvenile nasopharyngeal angiofibroma is still in its infancy. Although the molecular variation is not well understood, data obtained so far have prompted important research questions. Hence, multicentre collaborative molecular studies are needed to establish the aetiopathogenesis and establish molecular surrogates for clinical characteristics.

Copyright
Corresponding author
Address for correspondence: Dr A Mishra, A-1/19, Sector H Aliganj, Lucknow, Uttar Pradesh, India E-mail: amishra_ent@yahoo.com
Footnotes
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This review is based PhD work of Dr Anupam Mishra.

Footnotes
Linked references
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1 A Mishra , SC. Mishra Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow India. J Laryngol Otol 2016;130:363–8

5 Z Boghani , Q Husain , VV Kanumuri , MN Khan , S Sangvhi , JK Liu Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. Laryngoscope 2013;123:859–69

6 G Saylam , OT Yucel , A Sungur , M. Onerci Proliferation, angiogenesis and hormonal markers in juvenile nasopharyngeal angiofibroma. Int J Pediatr Otorhinolaryngol 2006;70:227–34

7 MM Brentani , O Butugan , CTF Oshima , H Torloni , LJ. Paiva Multiple steroid receptors in nasopharyngeal angiofibromas. Laryngoscope 1989;99:398401

8 ME Johns , RM MacLeod , RW. Cantrell Estrogen receptors in nasopharyngeal angiofibromas. Laryngoscope 1980;90:628–34

9 DA Lee , BR Rao , JS Meyer , PG Prioleau , WC. Bauer Hormonal receptor determination in juvenile nasopharyngeal angiofibromas. Cancer 1980;46:547–51

11 MM Farag , SE Ghanimah , A Ragaie , TH. Saleem Hormonal receptors in juvenile nasopharyngeal angiofibroma. Laryngoscope 1987;97:208–11

12 AR Antonelli , J Cappiello , CA Donajo , D Di Lorenzo , P Nicolai , A. Orlandini Diagnosis, staging and treatment of juvenile nasopharyngeal angiofibroma (JNA). Laryngoscope 1987;97:1319–25

14 Z Liu , J Wang , H Wang , D Wang , L Hu , Q Liu Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma. Acta Otolaryngol 2015;135:51–7

15 AG Montag , M Tretiakova , M. Richardson Steroid hormone receptor expression in nasopharyngeal angiofibromas. Consistent expression of estrogen receptor beta. Am J Clin Pathol 2006;125:832–7

17 M Zhang , X Sun , H Yu , L Hu , D. Wang Biological distinctions between juvenile nasopharyngeal angiofibroma and vascular malformation: an immunohistochemical study. Acta Histochem 2011;113:626–30

20 R Schuon , J Brieger , UR Heinrich , Y Roth , W Szyfter , WJ. Mann Immunohistochemical analysis of growth mechanisms in juvenile angiofibroma. Eur Arch Otorhinolaryngol 2007;264:389–94

22 SM Silveira , MA Custódio Domingues , O Butugan , MM Brentani , SR. Rogatto Tumor microenvironmental genomic alterations in juvenile nasopharyngeal angiofibroma. Head Neck 2012;34:485–92

23 MA Nagai , O Butugan , A Logullo , MM. Brentani Expression of growth factors, protooncogenes and p53 in nasopharyngeal angiofibromas. Laryngoscope 1996;106:190–5

26 J Pauli , R Gundelach , A Vanelli-Rees , G Rees , C Campbell , S Dubey Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology 2008;40:396400

27 DG Dillard , C Cohen , S Muller , J Del Gaudio , O Reichman , B Parrish Immunolocalization of activated transforming growth factor beta1 in juvenile nasopharyngeal angiofibroma. Arch Otolaryngol Head Neck Surg 2000;126:723–5

29 SC Abraham , EA Montgomery , FM Giardiello , TT. Wu Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. Am J Pathol 2001;158:1073–8

31 CM Coutinho-Camillo , MM Brentani , O Butugan , H Torloni , MA. Nagai Relaxation of imprinting of IGFII gene in juvenile nasopharyngeal angiofibromas. Diagn Mol Pathol 2003;12:5762

32 MP Maniglia , ME Ribeiro , NM Costa , ML Jacomini , TB Carvalho , FD Molina Molecular pathogenesis of juvenile nasopharyngeal angiofibroma in Brazilian patients. Pediatr Hematol Oncol 2013;30:616–22

33 K Gautham , SB Ogale , RU Shraddha , D. Ajay Expression of GSTM1 in angiofibromas. J Laryngol Otol 2002;116:352–4

34 M Krstulja , A Car , D Bonifacić , T Braut , M. Kujundzić Nasopharyngeal angiofibroma with intracellular accumulation of SPARC – a hypothesis (SPARC in nasopharyngeal angiofibroma). Med Hypotheses 2008;70:600–4

35 O Wendler , R Schäfer , B. Schick Mast cells and T-lymphocytes in juvenile angiofibromas. Eur Arch Otorhinolaryngol 2007;264:769–75

36 B Schick , S Wemmert , U Bechtel , P Nicolai , T Hofmann , W Golabek Comprehensive genomic analysis identifies MDM2 and AURKA as novel amplified genes in juvenile angiofibromas. Head Neck 2007;29:479–87

38 CM Coutinho , AS Bassini , LG Gutiérrez , O Butugan , LP Kowalski , MM Brentani Genetic alterations in Ki-ras and Ha-ras genes in juvenile nasopharyngeal angiofibromas and head and neck cancer. Sao Paulo Med J 1999;117:113–20

39 S Renkonen , P Heikkilä , C Haglund , AA Mäkitie , J. Hagström Tenascin-C. GLUT-1, and syndecan-2 expression in juvenile nasopharyngeal angiofibroma: correlations to vessel density and tumor stage. Head Neck 2013;35:1036–42

41 S Duerr , O Wendler , T Aigner , S Karosi , B. Schick Metalloproteinases in juvenile angiofibroma – a collagen rich tumor. Hum Pathol 2008;39:259–68

42 X Sun , L Guo , J Wang , H Wang , Z Liu , J Liu Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma: tissue microarray analysis. Int J Pediatr Otorhinolaryngol 2014:78:1232–8

44 S Renkonen , LO Cardell , P Mattila , M Lundberg , C Haglund , J Hagström Toll-like receptors 3, 7, and 9 in juvenile nasopharyngeal angiofibroma. APMIS 2015;123:439–44

45 M. Schiff Juvenile nasopharyngeal angiofibroma. Laryngoscope 1959;69:9811016.

46 H Martin , HE Ehrlich , JC. Abels Juvenile nasopharyngeal angiofibroma. Ann Surg 1948;127:513–36

47 S Johnsen , JH Kloster , M. Schiff The action of hormones on juvenile nasopharyngeal angiofibroma. Acta Otolaryngol 1966;61:153–60

48 H. Kumagami Testosterone and estradiol in juvenile nasopharyngeal angiofibroma tissue. Acta Otolaryngol 1991;111:569–73

49 H. Kumagami Sex hormones in juvenile nasopharyngeal angiofibroma tissue. Auris Nasus Larynx 1993;20:131–5

52 ZK Arbiser , JL Arbiser , C Cohen , AA. Gal Neuroendocrine lung tumors: grade correlates with proliferation but not angiogenesis. Mod Pathol 2001;14:1195–9

54 S Haggstrom , IF Lissbrant , A Bergh , JE. Damber Testosterone induces vascular endothelial growth factor synthesis in the ventral prostate in castrated rats. J Urol 1999;161:1620–5

56 KS Kimbro , JW. Simons Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer 2006;13:739–49

57 S Pelengaris , M Khan , G. Evan c-MYC: more than just a matter of life and death. Nat Rev Cancer 2002;2:764–6

59 D. Levens Disentangling the MYC web. Proc Natl Acad Sci U S A 2002;99:5757–9

60 AL Amir , M Barua , NC McKnight , S Cheng , X Yuan , SP. Balk A direct b-catenin independent interaction between androgen receptor and T cell factor. J Biol Chem 2003;278:30828–34

61 J Pauli , R Gundelach , A Vanelli-Rees , G Rees , C Campbell , S Dubey Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology 2008;40:396400

62 M. Barbacid Ras genes. Annu Rev Biochem 1987;56:779827

64 R Valanzano , MC Curia , G Aceto , S Veschi , L De Lellis , T Catalano Genetic evidence that juvenile nasopharyngeal angiofibroma is an integral FAP tumour. Gut 2005;54:1046–7

65 T Klockars , S Renkonen , I Leivo , J Hagström , AA. Mäkitie Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis. Fam Cancer 2010;9:401–3

66 B Schick , C Brunner , M Praetorius , PK Plinkert , S. Urbschat First evidence of genetic imbalances in angiofibromas. Laryngoscope 2002;112:397401

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