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Observations on Indoxyl in the Urine of Epileptics: A Preliminary Contribution on Epileptic Metabolism

  • Leonard D. H. Baugh (a1)

Undoubtedly in the past, the prominence of the major seizures in epilepsy led to a focussing of attention on the fit itself, while the accompanying phenomena were ignored or received scant attention. More recently the study of the phenomena associated with the seizures has increased our knowledge, and we realise that by epilepsy we refer to a “symptom-complex” (1). With regard to metabolic processes which occur, and which appear to be of importance, very little has been elucidated, although much work has been done on examination of body fluids, etc. With the hope that it may induce others to join in an endeavour to throw some light on these processes, this is presented, as a preliminary contribution from work done here on the study of epileptic metabolism. The paper is devoted mainly to the consideration of the indoxyl voided in the urine. The clinical examination of the urine of epileptics has been carried on since December, 1905. In the paper attention is drawn to brief summaries which show some of the variations in the output of indoxyl, and a modification of Jaffe's test submitted, which, it is considered, makes for greater clinical accuracy.

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(1) Turner, W. A.Epilepsy, pp. 202 and 189.
(2) Baugh, L. D. H.“Observations on Confusional Insanity,” Brit. Med. Journ., October 14th, 1905.
(3) Townsend, A. A. D.“Mental Depression and Melancholia considered in regard to Auto-intoxication, etc.,” Journ. Ment. Sci., January, 1905.
(4) Bruce, L. C.“The Clinical Significance of Indoxyl in the Urine,” Journ. Ment. Sci., July, 1906.
(5) Easterbrook, C. C.“Indicanuria and Insanity,” Journ. Ment. Sci., October, 1906.
(6) Lugaro, E.Modern Problems in Psychiatry. Translated by Orr, Drs. D. and Rows, R. G.
(7) Krainsky, . —Memoires Couronnes.
(8) Haig, . —Uric Acid, 1892.
(9) Bouchard, . —Auto-intoxication in Disease. Translated by Oliver, Dr.
(10) Gowers, . —Epilepsy, p. 11.
(11) Baugh, L. D. H.“Observations on Epileptics, illustrating their Reaction to the Purin in Diet,” Journ. Ment. Sci., July, 1910.
(12) Kauffmann, Max. —“Beitrage zur Pathologie des Stoffwechsells bei Psychosen,” Die Epilepsie, Jena, 1908.
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The British Journal of Psychiatry
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Observations on Indoxyl in the Urine of Epileptics: A Preliminary Contribution on Epileptic Metabolism

  • Leonard D. H. Baugh (a1)
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