It has long been known that there is a tendency to loss of the sense of smell in general paralytics. A. Voisin, indeed, regarded this as one of the earliest signs, and therefore of diagnostic value. The present investigation was carried out at Villejuif, on twenty-eight women in various stages of the disease. The method was one which has been frequently used by Dr. Toulouse in previous investigations, and consists essentially in a graduated series of solutions of camphor, various precautions being taken to avoid fallacies. The difficulties in the present case were very great, and to avoid error the experiments were repeated many times.
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