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Some Points in the Histology of Lymphogenous and Hæmatogenous Toxic Lesions of the Spinal Cord

  • David Orr and R. G. Rows
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At a quarterly meeting of this Association held last year at Nottingham, we showed the results of our experiments with toxins upon the spinal cord and brain of rabbits. Our main conclusion was, that the central nervous system could be infected by toxins passing up along the lymph channels of the perineural sheath. The method we employed in our experiments consisted in placing a celloidin capsule filled with a broth culture of an organism under the sciatic nerve or under the skin of the cheek; and we invariably found a resulting degeneration in the spinal cord or brain, according to the situation of the capsule. These lesions we found to be identical in morphological type and anatomical distribution with those found in the cord of early tabes dorsalis and in the brain and cord of general paralysis of the insane. The conclusion suggested by our work was that these two diseases, if toxic, were most probably infections of lymphogenous origin.

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(1) Contributed at the Quarterly Meeting in London, May 19th, 1908.

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The British Journal of Psychiatry
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  • EISSN: 2514-9946
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Some Points in the Histology of Lymphogenous and Hæmatogenous Toxic Lesions of the Spinal Cord

  • David Orr and R. G. Rows
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