Skip to main content
    • Aa
    • Aa

A Retrospective Comparison of Varenicline Monotherapy Versus the Combination of Varenicline and Bupropion or Bupropion and Nicotine Patches in a VA Tobacco Cessation Clinic

  • Dane Shiltz (a1), Angie Paniagua (a2) and James E. Hastings (a3)

Purpose: To determine whether the combination of bupropion SR and varenicline offers improved smoking cessation outcomes compared to varenicline monotherapy or to combination of bupro-pion SR and nicotine patch. Methods: This retrospective chart review included 489 volunteer enrolees in a Veterans Affairs (VA) tobacco cessation clinic who received one of the three treatments upon clinic enrolment. The study endpoints were smoking cessation and clinic completion rates, changes in the number of cigarettes smoked, carbon monoxide (CO) levels, urges to smoke, self-confidence to quit and medication-attributed adverse effects. Results: The relative smoking cessation rates were 33%, 32%, and 40% for bupropion SR and nicotine patch, bupropion SR and varenicline, and varenicline groups, respectively. The 0.21 p value established that no significant cessation rate differences existed between any of the groups. Varenicline alone or in combination was as well tolerated as the combination of bupropion SR and nicotine patch. Conclusions: The combination of bupropion SR and varenicline did not demonstrate any smoking cessation advantage over varenicline monotherapy or the combination of bupropion SR and nicotine patch and therefore do not support the use of bupro-pion SR and varenicline over varenicline monotherapy.

Corresponding author
*Address for correspondence: Dane Shiltz, Clinical Pharmacy Specialist, Inpatient Family Medicine, Methodist Hospital (Indiana University Health), 1701 N. Senate Blvd., AG 401, Indianapolis, IN.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Smoking Cessation
  • ISSN: -
  • EISSN: 1834-2612
  • URL: /core/journals/journal-of-smoking-cessation
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 0
Total number of PDF views: 3 *
Loading metrics...

Abstract views

Total abstract views: 46 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 30th April 2017. This data will be updated every 24 hours.