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Early detection of Alzheimer’s disease with a total score of the German CERAD

Published online by Cambridge University Press:  04 August 2010

MICHAEL M. EHRENSPERGER ,
MANFRED BERRES ,
KIRSTEN I. TAYLOR  and
ANDREAS U. MONSCH
MICHAEL M. EHRENSPERGER*
Affiliation:
Department of Geriatrics, University Hospital Basel, Basel, Switzerland
MANFRED BERRES
Affiliation:
Department of Mathematics and Technology, University of Applied Sciences, Koblenz, Germany
KIRSTEN I. TAYLOR
Affiliation:
Department of Geriatrics, University Hospital Basel, Basel, Switzerland Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
ANDREAS U. MONSCH
Affiliation:
Department of Geriatrics, University Hospital Basel, Basel, Switzerland
*
*Correspondence and reprint requests to: Michael M. Ehrensperger University Hospital Basel, Memory Clinic, Schanzenstrasse 55, 4031 Basel, Switzerland. E-mail: ehrenspergerm@uhbs.ch
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Abstract

The goal of the present study was to evaluate the diagnostic discriminability of three different global scores for the German version of the Consortium to Establish a Registry on Alzheimer’s Disease-Neuropsychological Assessment Battery (CERAD-NAB). The CERAD-NAB was administered to 1100 healthy control participants [NC; Mini-Mental State Examination (MMSE) mean = 28.9] and 352 patients with very mild Alzheimer’s disease (AD; MMSE mean = 26.1) at baseline and subsets of participants at follow-up an average of 2.4 (NC) and 1.2 (AD) years later. We calculated the following global scores: Chandler et al.’s (2005) score (summed raw scores), logistic regression on principal components analysis scores (PCA-LR), and logistic regression on demographically corrected CERAD-NAB variables (LR). Correct classification rates (CCR) were compared with areas under the receiver operating characteristics curves (AUC). The CCR of the LR score (AUC = .976) exceeded that of the PCA-LR, while the PCA-LR (AUC = .968) and Chandler (AUC = .968) scores performed comparably. Retest data improved the CCR of the PCA-LR and Chandler (trend) scores. Thus, for the German CERAD-NAB, Chandler et al.’s total score provided an effective global measure of cognitive functioning, whereby the inclusion of retest data tended to improve correct classification of individual cases. (JINS, 2010, 16, 910–920.)

Keywords

DementiaCognitionLongitudinal studyNeuropsychologyNeuropsychological testChange score
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 5 , September 2010 , pp. 910 - 920
Copyright
Copyright © The International Neuropsychological Society 2010

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