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Event-Related Functional Magnetic Resonance Imaging Changes during Relational Retrieval in Normal Aging and Amnestic Mild Cognitive Impairment

Published online by Cambridge University Press:  24 May 2012

Kelly S. Giovanello*
Affiliation:
Department of Psychology, The University of North Carolina, Chapel Hill, North Carolina Biomedical Research Imaging Center, The University of North Carolina, Chapel Hill, North Carolina
Felipe De Brigard
Affiliation:
Department of Psychology, The University of North Carolina, Chapel Hill, North Carolina Department of Philosophy, The University of North Carolina, Chapel Hill, North Carolina
Jaclyn Hennessey Ford
Affiliation:
Department of Psychology, The University of North Carolina, Chapel Hill, North Carolina
Daniel I. Kaufer
Affiliation:
Department of Neurology, The University of North Carolina, Chapel Hill, North Carolina
James R. Burke
Affiliation:
Joseph & Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, North Carolina Division of Neurology, Duke University Medical Center, Durham, North Carolina
Jeffrey N. Browndyke
Affiliation:
Joseph & Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, North Carolina Department of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, North Carolina
Kathleen A. Welsh-Bohmer
Affiliation:
Joseph & Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, North Carolina Division of Neurology, Duke University Medical Center, Durham, North Carolina Department of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, North Carolina
*
Correspondence and reprint requests to: Kelly S. Giovanello, Department of Psychology, The University of North Carolina, Campus Box 3270, Chapel Hill, NC 27713. E-mail: kgio@unc.edu

Abstract

The earliest cognitive deficits observed in amnestic mild cognitive impairment (aMCI) appear to center on memory tasks that require relational memory (RM), the ability to link or integrate unrelated pieces of information. RM impairments in aMCI likely reflect neural changes in the medial temporal lobe (MTL) and posterior parietal cortex (PPC). We tested the hypothesis that individuals with aMCI, as compared to cognitively normal (CN) controls, would recruit neural regions outside of the MTL and PPC to support relational memory. To this end, we directly compared the neural underpinnings of successful relational retrieval in aMCI and CN groups, using event-related functional magnetic resonance imaging (fMRI), holding constant the stimuli and encoding task. The fMRI data showed that the CN, compared to the aMCI, group activated left precuneus, left angular gyrus, right posterior cingulate, and right parahippocampal cortex during relational retrieval, while the aMCI group, relative to the CN group, activated superior temporal gyrus and supramarginal gyrus for this comparison. Such findings indicate an early shift in the functional neural architecture of relational retrieval in aMCI, and may prove useful in future studies aimed at capitalizing on functionally intact neural regions as targets for treatment and slowing of the disease course. (JINS, 2012, 18, 1–12)

Type
Research Articles
Copyright
Copyright © The International Neuropsychological Society 2012

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