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Semantic knowledge for famous names in mild cognitive impairment

Published online by Cambridge University Press:  01 January 2009

MICHAEL SEIDENBERG ,
LESLIE GUIDOTTI ,
KRISTY A. NIELSON ,
JOHN L. WOODARD ,
SALLY DURGERIAN ,
Qi ZHANG ,
AMELIA GANDER ,
PIERO ANTUONO  and
STEPHEN M. RAO
MICHAEL SEIDENBERG*
Affiliation:
Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois
LESLIE GUIDOTTI
Affiliation:
Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois
KRISTY A. NIELSON
Affiliation:
Department of Psychology and the Integrative Neuroscience Research Center, Marquette University, Milwaukee, Wisconsin Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
JOHN L. WOODARD
Affiliation:
Department of Psychology, Wayne State University, Detroit, Michigan
SALLY DURGERIAN
Affiliation:
Functional Imaging Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
Qi ZHANG
Affiliation:
Functional Imaging Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
AMELIA GANDER
Affiliation:
Functional Imaging Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
PIERO ANTUONO
Affiliation:
Foley Center for Aging and Development, Medical College of Wisconsin, Milwaukee, Wisconsin Functional Imaging Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin
STEPHEN M. RAO
Affiliation:
Schey Center for Cognitive Neuroimaging, Cleveland Clinic, Cleveland, Ohio
*
*Correspondence and reprint requests to: Michael Seidenberg, 3333 Green Bay Road, North Chicago, IL 60064. E-mail: michael.seidenberg@rosalindfranklin.edu
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Abstract

Person identification represents a unique category of semantic knowledge that is commonly impaired in Alzheimer’s disease (AD), but has received relatively little investigation in patients with mild cognitive impairment (MCI). The current study examined the retrieval of semantic knowledge for famous names from three time epochs (recent, remote, and enduring) in two participant groups: 23 amnestic MCI (aMCI) patients and 23 healthy elderly controls. The aMCI group was less accurate and produced less semantic knowledge than controls for famous names. Names from the enduring period were recognized faster than both recent and remote names in both groups, and remote names were recognized more quickly than recent names. Episodic memory performance was correlated with greater semantic knowledge particularly for recent names. We suggest that the anterograde memory deficits in the aMCI group interferes with learning of recent famous names and as a result produces difficulties with updating and integrating new semantic information with previously stored information. The implications of these findings for characterizing semantic memory deficits in MCI are discussed. (JINS, 2009, 15, 9–18.)

Keywords

Semantic memoryAgingFame recognitionPerson identityRemote memoryTemporal gradient

Information

Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 1 , January 2009 , pp. 9 - 18
Copyright
Copyright © INS 2009

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