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Cognitive disinhibition and socioemotional functioning in Alzheimer's disease

Published online by Cambridge University Press:  18 October 2007

SCOTT NASH ,
JULIE D. HENRY ,
SKYE MCDONALD ,
INGERITH MARTIN ,
HENRY BRODATY  and
MARIE-ANDREE PEEK-O'LEARY
SCOTT NASH
Affiliation:
School of Psychology, University of New South Wales, Sydney 2052, Australia.
JULIE D. HENRY
Affiliation:
School of Psychology, University of New South Wales, Sydney 2052, Australia.
SKYE MCDONALD
Affiliation:
School of Psychology, University of New South Wales, Sydney 2052, Australia.
INGERITH MARTIN
Affiliation:
Aged Care Unit, Royal North Shore Hospital, Sydney 2065, Australia.
HENRY BRODATY
Affiliation:
Age Care Mental Health, School of Psychiatry, University of New South Wales, Sydney 2052, Australia. Memory Disorders Clinic, Prince of Wales Hospital, Sydney 2031, Australia
MARIE-ANDREE PEEK-O'LEARY
Affiliation:
School of Psychology, University of New South Wales, Sydney 2052, Australia.
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Abstract

Individuals with Alzheimer's disease (AD) experience difficulties with socioemotional functioning, and it has been proposed that cognitive disinhibition may be one potential mechanism that contributes to difficulties in this area. To test this possibility, twenty individuals with AD and 20 demographically matched controls were administered self-report measures of depression, emotion regulation and empathy, in addition to a behavioral measure that has proven to be very sensitive to inhibitory failures (the Hayling Sentence Completion Test). Relative to controls AD participants exhibited increased inhibitory failures on the Hayling, and self-reported significantly reduced cognitive empathy, but did not differ with respect to affective empathy, depression or perceived capacity for emotion regulation. Controlling for general cognitive status, in the AD (but not the control) group, reduced cognitive inhibition was associated with lower levels of depression. The theoretical and practical implications of these results are discussed. (JINS, 2007, 13, 1060–1064.)

Keywords

DementiaInhibitory controlDepressionEmotion regulationCognitive empathyAffective empathy
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 6 , November 2007 , pp. 1060 - 1064
Copyright
© 2007 The International Neuropsychological Society

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References

REFERENCES

Alexopoulos, G.S. (2003). Role of executive function in late-life depression. Journal of Clinical Psychiatry, 64, 18–23.Google Scholar
Amieva, H., Phillips, L.H., Della Sala, S., & Henry, J.D. (2004). Inhibitory functioning in Alzheimer's disease. Brain, 127, 949–964.Google Scholar
Blanchard-Fields, F., Stein, R., & Watson, T.L. (2004). Age differences in emotion-regulation strategies in handling everyday problems. Journals of Gerontology, 59B, 261–269.Google Scholar
Burgess, P.W. & Shallice, T. (1996). Response suppression, initiation and strategy use following frontal lobe lesions. Neuropsychologia, 34, 263–272.Google Scholar
Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Lawrence Erlbaum Associates.
Davis, M.H. (1983). Measuring individual differences in empathy: Evidence for a multidimensional approach. Journal of Personality and Social Psychology, 44, 113–126.Google Scholar
Decety, J. & Jackson, P.L. (2004). The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews, 3, 406–412.Google Scholar
Frank, L., Lloyd, A., Flynn, J.A., Kleinman, L., Matza, L.S., Margolis, M.K., Bowman, L., & Bullock, R. (2006). Impact of cognitive impairment on mild dementia patients and mild cognitive impairment patients and their informants. International Psychogeriatrics, 18, 151–162.Google Scholar
Gratz, K.L. & Roemer, L. (2004). Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the difficulties in emotion regulation scale. Journal of Psychopathology and Behavioral Assessment, 26, 41–54.Google Scholar
Kashiwa, Y., Kitabayashi, Y., Narumoto, J., Nakamura, K., Ueda, H., & Fukui, K. (2005). Anosognosia in Alzheimer's disease: association with patient characteristics, psychiatric symptoms and cognitive deficits. Psychiatry & Clinical Neurosciences, 59, 697–704.Google Scholar
Lezak, M.D., Howieson, D.B., & Loring, D.W. (2004). Neuropsychological assessment (Fourth ed.). New York: Oxford University Press.
Lough, S., Kipps, C.M., Treise, C., Watson, P., Blair, J.R., & Hodges, J.R. (2006). Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia, 44, 950–958.Google Scholar
Mathuranath, P.S., Nestor, P.J., Berrios, G.E., Rakowicz, W., & Hodges, J.R. (2000). A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia. Neurology, 55, 1613–1620.Google Scholar
Peters, F., Perani, D., Herholz, K., Holthoff, V., Beuthien-Baumann, B., Sorbi, S., Pupi, A., Degueldre, C., Lemaire, C., Collette, F., & Salmon, E. (2006). Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 21, 373–379.Google Scholar
Rankin, K.P., Baldwin, E., Pace-Savitsky, C., Kramer, J.H., & Miller, B.L. (2005). Self awareness and personality change in dementia. Journal of Neurology, Neurosurgery and Psychiatry, 76, 632–639.Google Scholar
Rankin, K.P., Gorno-Tempini, M.L., Allison, S.C., Stanley, C.M., Glenn, S., Weiner, M.W., Miller, B.L. (2006). Structural anatomy of empathy in neurodegenerative disease. Brain, 129, 2945–2956.Google Scholar
Rapp, M.A., Dahlman, K., Sano, M., Grossman, H.T., Haroutunian, V., & Gorman, J.M. (2005). Neuropsychological differences between late-onset and recurrent geriatric major depression. American Journal of Psychiatry, 162, 691–698.Google Scholar
Starkstein, S.E., Jorge, R., Mizrahi, R., & Robinson, R.G. (2005). The construct of minor and major depression in Alzheimer's Disease. American Journal of Psychiatry, 162, 2086–2093.Google Scholar
Von Hippel, W., Vasey, M.W., Gonda, T., & Stern, T., (in press). Executive function deficits, rumination, and late-onset depressive symptoms in older adults. Cognitive Therapy and Research.
Watkins, E. & Baracaia, S. (2002). Rumination and social problem-solving in depression. Behaviour Research and Therapy, 40, 1179–1189.Google Scholar
Watkins, E. & Brown, R.G. (2002). Rumination and executive function in depression: An experimental study. Journal of Neurology, Neurosurgery & Psychiatry, 72, 400–402.Google Scholar
Yesavage, J.A., Brink, T.L., Rose, T.L., Lum, O., Huang, V., Adey, M., & Leirer, V.O. (1983). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17, 37–49.Google Scholar