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Neural substrates of syntactic mapping treatment: An fMRI study of two cases


Two patients (G01, J02) with chronic nonfluent aphasia and sentence production deficits received syntactic mapping treatment to improve sentence production. The patients had dramatically different outcomes in that improved syntax production generalized to nontreatment tasks for G01, but not for JO2. To learn how treatment influenced the neural substrates for syntax production, both patients underwent pre- and posttreatment functional magnetic resonance imaging (fMRI) of sentence generation. G01 showed more robust activity posttreatment than pretreatment in Broca's area; ventral temporal activity decreased slightly from pre- to posttreatment. Comparison of J02's pretreatment and posttreatment images revealed little change, although activity was more diffuse pre- than posttreatment. Findings suggest that for G01, rehabilitation led to engagement of an area (Broca's area) used minimally during the pretreatment scan, whereas for J02, rehabilitation may have led to more efficient use of areas already involved in sentence generation during the pretreatment scan. fMRI findings are discussed in the context of sentence-production outcome and generalization. (JINS, 2006, 12, 132–146.)

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Reprint requests to: Bruce Crosson, Ph.D., Department of Clinical and Health Psychology, University of Florida Health Science Center, Box 100165, Gainesville, FL 32610-0165. E-mail:
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Ackermann, H. & Riecker, A. (2004). The contribution of the insula to motor aspects of speech production: A review and a hypothesis. Brain and Language, 89, 320328.

Aguirre, G.K., Zarahn, D., & D'Esposito, M. (1998). The variability of human BOLD hemodynamic responses. NeuroImage, 8, 360369.

Barch, D.M., Sabb, F.W., Carter, C.S., Braver, T.S., Noll, D.C., & Cohen, J.D. (1999). Overt verbal responding during fMRI scanning: Empirical investigations of problems and potential solutions. NeuroImage, 10, 642657.

Basso, A., Gardelli, M., Grassi, M.P., & Mariotti, M. (1989). The role of the right hemisphere in recovery from aphasia: Two case studies. Cortex, 25, 555566.

Belin, P., Van Eeckhout, P., Zilbovicius, M., Remy, P., Francois, C., Guillaume, S., Chain, F., Rancurel, G., & Samson, Y. (1996). Recovery from nonfluent aphasia after melodic intonation therapy: A PET study. Neurology, 47, 15041511.

Birn, R.M., Bandettini, P.A., Cox, R.W., & Shaker, R. (1999). Event-related fMRI of tasks involving brief motion. Human Brain Mapping, 7, 106114.

Birn, R.M., Saad, Z.S., & Bandettini, P.A. (2001). Spatial heterogeneity of the nonlinear dynamics in the fMRI BOLD response. NeuroImage, 14, 817826.

Byng, S. (1988). Sentence processing deficits: Theory and therapy. Cognitive Neuropsychology, 5, 629676.

Byng, S., Nickels, L., & Black, M. (1994). Replicating therapy for mapping deficits in agrammatism: Remapping the deficit?Aphasiology, 8, 315341.

Cabeza, R., Anderson, N.D., Locantore, J.K., & McIntosh, A.R. (2002). Aging gracefully: Compensatory brain activity in high-performing older adults. NeuroImage, 17, 13941402.

Cao, Y., Vikingstad, E.M., George, K.P., Johnson, A.F., & Welch, K.M.A. (1999). Cortical language activation in stroke patients recovering from aphasia with functional MRI. Stroke, 30, 23312340.

Caplan, D., Albert, N., Waters, G., & Olivieri, A. (2000). Activation of Broca's area by syntactic processing under conditions of concurrent articulation. Human Brain Mapping, 9, 6571.

Caplan, D., Vijayan, S., Kuperberg, G., West, C., Waters, G., Greve, D., & Dale, A.M. (2001). Vascular responses to syntactic processing: Event-related fMRI study of relative clauses. Human Brain Mapping, 15, 2638.

Caplan, D. & Waters, G.S. (1999). Verbal working memory and sentence comprehension. Behavioral and Brain Sciences, 22, 7794.

Caramazza, A. & Miceli, G. (1991). Selective impairment of thematic role assignment in sentence processing. Brain and Language, 41, 402436.

Carpenter, P.A., Just, M.A., Keller, T.A., Eddy, W.E., & Thulborn, K.R. (1999). Time course of fMRI-activation in language and spatial networks during sentence comprehension. NeuroImage, 10, 216224.

Chatterjee, A., Maher, L.M., Rothi, L.J.G., & Heilman, K.M. (1995). Asyntactic thematic role assignment: The use of temporal-spatial strategy. Brain and Language, 49, 125139.

Cornelissen, K., Laine, M., Tarkiainen, A., Järvensivu, T., Martin, N., & Salmelin, R. (2003). Adult brain plasticity elicited by anomia treatment. Journal of Cognitive Neuroscience, 15, 444461.

Cox, R.W. (1996). AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Computers in Biomedical Research, 29, 162173.

Crosson, B., Moore, A.B., Gopinath, K., White, K.D., Wierenga, C.E., Gaiefsky, M.E., Fabrizio, K.R., Peck, K.K., Soltysik, D., Milstead, C., Briggs, R.W., Conway, T.W., & Rothi, L.J.G. (2005). Role of the right and left hemispheres in recovery of function during treatment of intention in aphasia. Journal of Cognitive Neuroscience, 17, 392406.

Dapretto, M. & Bookheimer, S.Y. (1999). Form and content: Dissociating syntax and semantics in sentence comprehension. Neuron, 24, 427432.

Embick, E., Marantz, A., Miyashita, Y., O'Neil, W., & Sakai, K.L. (2000). A syntactic specialization for Broca's area. Proceedings of the National Academy of Science, 97, 61506154.

Foundas, A.L., Daniels, S.K., & Vasterling, J.J. (1998). Anomia: Case studies with lesion localization. NeuroCase, 4, 3543.

Grodzinsky, Y. (2000). The neurology of syntax: Language use without Broca's area. Behavioral and Brain Sciences, 23, 171.

Heiss, W., Karbe, H., Weber-Luxenburger, G., Herholz, K., Kessler, J., Pietrzyk, U., & Pawlik, G. (1997). Speech-induced cerebral metabolic activation reflects recovery from aphasia. Journal of the Neurological Sciences, 145, 213217.

Heiss, W.D., Kessler, J., Thiel, A., Ghaemi, M., & Karbe, H. (1999). Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia. Annals of Neurology, 45, 430438.

Indefrey, P., Brown, C.M., Hellwig, F., Amunts, K., Herzog, H., Seitz, R.J., & Hagoort, P. (2001). A neural correlate of syntactic encoding during speech production. Proceedings of the National Academy of Science, 98, 59335936.

Indefrey, P., Hellwig, F., Herzog, H., Seitz, R.J., & Hagoort, P. (2004). Neural responses to the production and comprehension of syntax in identical utterances. Brain and Language, 89, 312319.

Ishai, A., Ungerleider, L., Martin, A., Schouten, J., & Haxby, J. (1999). Distributed representation of objects in the human ventral visual pathway. Proceedings of the National Academy of Science, 96, 93799384.

Jones, E.V. (1986). Building the foundations for sentence production in a non-fluent aphasic. British Journal of Disorders of Communication, 21, 6382.

Just, M.A., Carpenter, P.A., Keller, T.A., Eddy, W.F., & Thulborn, K.R. (1996). Brain activation modulated by sentence comprehension. Science, 274, 114116.

Kan, I.P. & Thompson-Schill, S.L. (2004). Effect of name agreement on prefrontal activity during overt and covert picture naming. Cognitive, Affective, & Behavioral Neuroscience, 4, 4357.

Karbe, H., Thiel, A., Weber-Luxenburger, G., Herholz, K., Kessler, J., & Heiss, W.D. (1998). Brain plasticity in postroke aphasia: What is the contribution of the right hemisphere?Brain and Language, 64, 215230.

King, K.F., Foo, T.K.F., & Crawford, C.R. (1995). Optimized gradient waveforms for spiral scanning. Magnetic Resonance in Medicine, 34, 156160.

Kroll, J.F. & Potter, M.C. (1984). Recognizing words, pictures, and concepts: A comparison of lexical, object, and reality decisions. Journal of Verbal Learning and Verbal Behavior, 23, 3966.

Macovski, A. (1985). Volumetric NMR imaging with time-varying gradients. Magnetic Resonance Imaging in Medicine, 2, 2940.

Maher, L., Chatterjee, A., Rothi, L.J.G., & Heilman, K. (1995). Agrammatic sentence production: The use of a temporal-spatial strategy. Brain and Language, 49, 105124.

Musso, M., Weiller, C., Kiebel, S., Muller, S.P., Bulau, P., & Rijntjes, M. (1999). Training-induced brain plasticity in aphasia. Brain, 122, 17811790.

Naeser, M.A., Baker, E.H., Palumbo, C.L., Nicholas, M., Alexander, M.P., Samaraweera, R., Prete, M.N., Hodge, S.N., & Weissman, T. (1998). Lesion site patterns in severe, nonverbal aphasia to predict outcome with a computer-assisted treatment program. Archives of Neurology, 55, 14381448.

Naeser, M.A., Palumbo, A.L., Helm-Estabrooks, N., Stiassny-Eder, D., & Albert, M.L. (1989). Severe nonfluency in aphasia: Role of the medial subcallosal fasciculus and other white matter pathways in recovery of spontaneous speech. Brain, 112, 138.

Newman, A.J., Pancheva, R., Ozawa, K., Neville, H.J., & Ullman, M.T. (2001). An event-related fMRI study of syntactic and semantic violations. Journal of Psycholinguistic Research, 30, 339364.

Ni, W., Constable, R.T., Mencl, W.E., Pugh, K.R., Fulbright, R.K., Shaywitz, S.E., Shaywitz, B.A., Gore, J.C., & Shankweiler, D. (2000). An event-related neuroimaging study distinguishing form and content in sentence processing. Journal of Cognitive Neuroscience, 12, 120133.

Noll, D.C., Cohen, J.D., Meyer, C.H., & Schneider, W.J. (1995). Spiral k-space MR imaging of cortical activation. Magnetic Resonance Imaging, 5, 4956.

Palmer, E.D., Rosen, H.J., Ojemann, J.G., Buckner, R.L., Kelley, W.M., & Petersen, S.E. (2001). An event-related fMRI study of overt and covert word stem completion. NeuroImage, 14, 182193.

Peck, K.K., Moore, A.B., Crosson, B., Gaiefsky, M., Gopinath, K.S., White, K., & Briggs, R.W. (2004a). Pre and post fMRI of an aphasia therapy: Shifts in hemodynamic time to peak during an overt language task. Stroke, 35, 554559.

Peck, K.K., Wierenga, C.E., Moore, A.B., Maher, L., Gopinath, K., Gaiefsky, M., Briggs, R.W., & Crosson, B. (2004b). Comparison of baseline conditions to investigate syntactic production using functional magnetic resonance imaging. NeuroImage, 23, 104110.

Perani, D., Cappa, S.F., Tettamanti, M., Rosa, M., Scifo, P., Miozzo, A., Basso, A., & Fazio, F. (2003). An fMRI study of word retrieval in aphasia. Brain and Language, 85, 357368.

Petersen, S.E., van Mier, H., Fiez, J.A., & Raichle, M.E. (1998). The effects of practice on the functional anatomy of task performance. Proceedings of the National Academy of Science, USA, 95, 853860.

Reuter-Lorenz, P. (2002). New visions of the aging mind and brain. Trends in Cognitive Science, 6, 394.

Rosen, H.J., Petersen, S.E., Linenweber, M.R., Snyder, A.Z., White, D.A., Chapman, L., Dromerick, A.W., Fiez, J.A., & Corbetta, M.D. (2000). Neural correlates of recovery from aphasia after damage to left inferior frontal cortex. Neurology, 55, 18831894.

Schwartz, M.F., Saffron, E.M., Bloch, D.E., & Dell, G.S. (1994a). Disordered speech production in aphasic and normal speakers. Brain and Language, 47, 5288.

Schwartz, M.F., Saffron, E.M., Fink, R., & Myers, J.L. (1994b). Mapping therapy: A treatment programme for agrammatism. Aphasiology, 8, 1954.

Schwartz, M.F., Saffron, E.M., & Marin, O.S.M. (1980). The word order problem in agrammatism. I. Comprehension. Brain and Language, 10, 249262.

Stowe, L.A., Broere, C.A.J., Paans, A.M., Wijers, A.A., Mulder, B., Vaalburg, W., & Zwarts, F. (1998). Localizing components of a complex task: Sentence processing and working memory. Neuroreport, 9, 29952999.

Swinney, D., Zurif, E., Prahter, P., & Love, T. (1996). Neurological distribution of processing resources underlying language comprehension. Journal of Cognitive Neuroscience, 8, 174184.

Thompson, C.K., Shapiro, L.P., Ballard, K.J., Jacobs, B.J., Schneider, S.S., & Tait, M.E. (1997). Training and generalized production of wh- and NP-movement structure in agrammatic aphasia. Journal of Speech, Language, and Hearing Research, 40, 228244.

Tryon, W.W. (1982). A simplified time-series analysis for evaluating treatment interventions. Journal of Applied Behavior Analysis, 15, 423429.

Ungerleider, L.G. & Haxby, J.V. (1994). ‘What’ and ‘where’ in the human brain. Current Opinion in Neurobiology, 4, 157165.

Weisskoff, R.M. (1996). Simpled measurement of scanner stability for functional NMR imaging of activation in the brain. Magnetic Resonance in Medicine, 36, 643645.

Wolery, M., Holcombe, A., Cybriwsky, C., Doyle, P.M., Schuester, J.W., Ault, J., & Gast, D.L. (1992). Constant time delay with discrete responses: A review of effectiveness and demographic, procedural and methodological parameters. Research and Developmental Disabilities, 13, 239266.

Zarahn, E., Aguirre, G.K., & D'Esposito, M. (1997). Empirical analysis of BOLD fMRI statistics: I. Spatially unsmoothed data collected under null-hypothesis conditions. NeuroImage, 5, 179197.

Zurif, E., Swinney, D., Prather, P., Solomon, J., & Bushell, C. (1993). An on-line analysis of syntactic processing in Broca's and Wernicke's aphasia. Brain and Language, 45, 448464.

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