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Neuropsychological Functioning in Girls with Premature Adrenarche

  • A. Tissot (a1) (a2), L.D. Dorn (a1) (a2), D. Rotenstein (a3), S.R. Rose (a2) (a4), L.M. Sontag-Padilla (a5), C.L. Jillard (a6), S.F. Witchel (a7) (a8), S.L. Berga (a9), T.L. Loucks (a9) and S.R. Beers (a10)...
Abstract
Abstract

Contemporary research indicates that brain development occurs during childhood and into early adulthood, particularly in certain regions. A critical question is whether premature or atypical hormone exposures impact brain development (e.g., structure) or function (e.g., neuropsychological functioning). The current study enrolled 40 girls (aged 6–8 years) diagnosed with premature adrenarche (PA) and a comparison group of 36 girls with on-time maturation. It was hypothesized that girls with PA would demonstrate lower IQ and performance on several neuropsychological tasks. The potential for a sexually dimorphic neuropsychological profile in PA was also explored. No significant univariate or multivariate group differences emerged for any neuropsychological instrument. However, effect size confidence intervals contained medium-sized group differences at the subscale level. On-time girls performed better on verbal, working memory, and visuospatial tasks. Girls with PA showed improved attention, but not a sexually dimorphic profile. These results, though preliminary, suggest that premature maturation may influence neuropsychological functioning. (JINS, 2012, 18, 151–156)

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Corresponding author
Correspondence and reprint requests to: Abbigail Tissot, Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, ML 4000, Cincinnati, Ohio 45229-3039. E-mail: abbigail.tissot@cchmc.org
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S.A. Berenbaum , A.M. Beltz (2011). Sexual differentiation of human behavior: Effects of prenatal and pubertal organizational hormones. Frontiers in Neuroendocrinology, 32, 183200.

N. Butters , E. Granholm , D. Salmon , I. Grant , J. Wolfe (1987). Episodic and semantic memory: A comparison of amnestic and demented patients. Journal of Clinical and Experimental Neuropsychology, 9, 479497.

J. Cohen (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Mahwah, NJ: Lawrence Erlbaum Associates.

M.L. Collaer , M.E. Geffner , F.R. Kaufman , B. Buckingham , M. Hines (2002). Cognitive and behavioral characteristics of Turner Syndrome: Exploring a role for ovarian hormones in female sexual differentiation. Hormones and Behavior, 41, 139155.

D.C. Delis , J.H. Kramer , E. Kaplan , B.A. Ober (1994). The California Verbal Learning Test-Children's Version. San Antonio, TX: Psychological Corporation.

L.D. Dorn , S.F. Hitt , D. Rotenstein (1999). Biopsychological and cognitive difference in children with premature vs on-time adrenarche. Archives of Pediatric and Adolescent Medicine, 153, 137146.

L.D. Dorn , S.R. Rose , D. Rotenstein , E.J. Susman , B. Huang , T.L. Loucks , S.L. Berga (2008). Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche. Journal of Pediatric Endocrinology & Metabolism, 21, 439448.

J.N. Giedd (2008). The teen brain: Insights from neuroimaging. Journal of Adolescent Health, 42, 335343.

R.K. Heaton , G.J. Chelune , J.L. Talley , G.G. Kay , G. Curtiss (1993). Wisconsin card sorting test manual: Revised and expanded. Odessa, FL: Psychological Assessment Resources.

M. Hines (2004). Brain gender. Oxford, UK: Oxford University Press.

P.R. Huttenlocher (1999). Dendritic and synaptic development in human cerebral cortex: Time course and critical periods. Developmental Neuropsychology, 16, 347349.

L. Ibanez , J. DiMartino-Nardi , N. Potau , P. Saenger (2000). Premature adrenarche – Normal variant or forerunner of adult disease? Endocrine Reviews, 21, 671696.

S. Laakso , P. Utriainen , M. Laakso , R. Voutilainen , J. Jääskeläinen (2010). Polymorphism Pro12Ala of PPARG in prepubertal children with premature adrenarche and its association with growth in healthy children. Hormone Research in Paediatrics, 74, 365371.

R.K. Lenroot , J.N. Giedd (2010). Sex differences in the adolescent brain. Brain and Cognition, 72, 4655.

N. Maninger , W.M. Wolkowitz , V.I. Reus , E. Epel , S.H. Mellon (2009). Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Frontiers in Neuroendocrinology, 30, 6591.

W.A. Marshall , J.M. Tanner (1969). Variations in pattern of pubertal changes in girls. Archives of Disease in Childhood, 44, 291303.

S.C. Mueller , D. Mandell , E.W. Leschek , D.S. Pine , D.P. Merke , M. Ernst (2009). Early hyperandrogenism affects the development of hippocampal function: Preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty. Journal of Child and Adolescent Psychopharmacology, 19, 4150.

R. Nass , S. Baker , A. Sadler , J. Sidtis (1990). The effects of precocious adrenarche on cognition and hemispheric specialization. Brain and Cognition, 14, 5969.

M.S. Ritsner , A. Gibel , Y. Ratner , G. Tsinovoy , R.D. Strous (2006). Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: A randomized, double-blind, placebo-controlled, crossover trial. Journal of Clinical Psychopharmacology, 26, 495499.

J. Rovet (1983). Cognitive and neuropsychological test performance of persons with abnormalities of adolescent development: A test of Waber's hypothesis. Child Development, 54, 941950.

R.D. Vanderploeg , T.A. Crowell , G. Curtiss (2001). Verbal learning and memory deficits in traumatic brain injury: Encoding, consolidation, and retrieval. Journal of Clinical and Experimental Neuropsychology, 23, 185195.

D. Waber (1976). Sex differences in cognition: A function of maturation rate? Science, 192, 572574.

D. Wechsler (1991). Wechsler Intelligence Scale for Children (3rd ed.). San Antonio, TX: Psychological Corporation.

T.J. Whitford , C.J. Rennie , S.M. Grieve , C.R. Clark , E. Gordon , L.M. Williams (2007). Brain maturation in adolescence: Concurrent changes in neuroanatomy and neurophysiology. Human Brain Mapping, 28, 228237.

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Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
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