Hostname: page-component-76fb5796d-9pm4c Total loading time: 0 Render date: 2024-04-26T07:29:53.432Z Has data issue: false hasContentIssue false
  • English
  • Français

Hippocampal volume and retention in Alzheimer's disease

Published online by Cambridge University Press:  01 July 2004

JOEL H. KRAMER ,
NORBERT SCHUFF ,
BRUCE R. REED ,
DAN MUNGAS ,
AN-TAO DU ,
HOWARD J. ROSEN ,
WILLIAM J. JAGUST ,
BRUCE L. MILLER ,
MICHAEL W. WEINER  and
HELENA C. CHUI
JOEL H. KRAMER
Affiliation:
Department of Neurology, University of California at San Francisco
NORBERT SCHUFF
Affiliation:
Department of Radiology, University of California at San Francisco
BRUCE R. REED
Affiliation:
Department of Neurology, University of California at Davis
DAN MUNGAS
Affiliation:
Department of Neurology, University of California at Davis
AN-TAO DU
Affiliation:
Department of Radiology, University of California at San Francisco
HOWARD J. ROSEN
Affiliation:
Department of Neurology, University of California at San Francisco
WILLIAM J. JAGUST
Affiliation:
Department of Neurology, University of California at Davis
BRUCE L. MILLER
Affiliation:
Department of Neurology, University of California at San Francisco
MICHAEL W. WEINER
Affiliation:
Department of Radiology, University of California at San Francisco
HELENA C. CHUI
Affiliation:
Department of Neurology, University of Southern California at Downey
Get access Rights & Permissions [Opens in a new window]

Abstract

This study tested the hypothesis that the hippocampus has a relatively specific role in retaining information over delays. Thirty-seven subjects with probable Alzheimer's disease were evaluated with a verbal memory task and structural MRI. Cortical gray matter but not hippocampal volume predicted immediate free recall. In contrast, hippocampal volume was the best predictor of how well information was retained over a delay, even after controlling for levels of immediate recall. Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories. (JINS, 2004, 10, 639–643.)

Keywords

HippocampusMemoryConsolidationAlzheimer's disease
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 4 , July 2004 , pp. 639 - 643
Copyright
2004 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Braak, H. & Braak, E. (1995). Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiology of Aging, 16, 271–284.CrossRefGoogle Scholar
Cahn, D.A., Sullivan, E.V., Shear, P.K., Marsh, L., Fama, R., Lim, K.O., Yesavage, J.A., Tinklenberg, J.R., & Pfefferbaum, A. (1998). Structural MRI correlates of recognition memory in Alzheimer's disease. Journal of the International Neuropsychological Society, 4, 106–114.CrossRefGoogle Scholar
Christensen, G.E., Joshi, S.C., & Miller, M.I. (1997). Volumetric transformation of brain anatomy. IEEE Transactions Medical Imaging, 16, 864–877.CrossRefGoogle Scholar
Delis, D.C., Freeland, J., Kramer, J.H., & Kaplan, E. (1988). Integrating clinical assessment with cognitive neuroscience: construct validation of the California Verbal Learning Test. Journal of Consulting and Clinical Psychology, 56, 123–130.CrossRefGoogle Scholar
Fama, R., Sullivan, E.V., Shear, P.K., Marsh, L., Yesavage, J.A., Tinklenberg, J.R., Lim, K.O., & Pfefferbaum, A. (1997). Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease. Archives of Neurology, 54, 719–728.CrossRefGoogle Scholar
Fein, G., Di Sclafani, V., Tanabe, J., Cardenas, V., Weiner, M.W., Jagust, W.J., Reed, B.R., Norman, D., Schuff, N., Kusdra, L., Greenfield, T., & Chui, H. (2000). Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease. Neurology, 55, 1626–1635.CrossRefGoogle Scholar
Fletcher, P.C. & Henson, R.N. (2001). Frontal lobes and human memory: Insights from functional neuroimaging. Brain, 124, 849–881.CrossRefGoogle Scholar
Hackert, V.H., den Heijer, T., Oudkerk, M., Koudstaal, P.J., Hofman, A., & Breteler, M.M. (2002). Hippocampal head size associated with verbal memory performance in nondemented elderly. Neuroimage, 17, 1365–1372.CrossRefGoogle Scholar
Hsu, Y.Y., Schuff, N., Du, A.T., Mark, K., Zhu, X., Hardin, D., & Weiner, M.W. (2002). Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia. Journal of Magnetic Resonance Imaging, 16, 305–310.CrossRefGoogle Scholar
Jack, C.R., Jr., Petersen, R.C., Xu, Y.C., O'Brien, P.C., Smith, G.E., Ivnik, R.J., Boeve, B.F., Waring, S.C., Tangalos, E.G., & Kokmen, E. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology, 52, 1397–1403.CrossRefGoogle Scholar
Kohler, S., Black, S.E., Sinden, M., Szekely, C., Kidron, D., Parker, J.L., Foster, J.K., Moscovitch, M., Winocour, G., Szalai, J.P., Bronskill, M.J., & Winocur, G. (1998). Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: An MR volumetry study in Alzheimer's disease. Neuropsychologia, 36, 901–914.CrossRefGoogle Scholar
Kopelman, M.D., Lasserson, D., Kingsley, D., Bello, F., Rush, C., Stanhope, N., Stevens, T., Goodman, G., Heilpern, G., Kendall, B., & Colchester, A. (2001). Structural MRI volumetric analysis in patients with organic amnesia, 2: Correlations with anterograde memory and executive tests in 40 patients. Journal of Neurology, Neurosurgery and Psychiatry, 71, 23–28.CrossRefGoogle Scholar
Kramer, J.H. & Delis, D.C. (1998). Neuropsychological assessment of memory. In G. Goldstein & P.D. Nussbaum (Eds.), Neuropsychology. Human brain function: Assessment and rehabilitation (pp. 333–356). New York: Plenum Press.
Laakso, M.P., Soininen, H., Partanen, K., Helkala, E.L., Hartikainen, P., Vainio, P., Hallikainen, M., Hänninen, T., & Riekkinen, P.J., Sr. (1995). Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: Correlation with memory functions. Journal of Neural Transmission. Parkinsons Disease and Dementia Section, 9, 73–86.CrossRefGoogle Scholar
Mungas, D., Jagust, W.J., Reed, B.R., Kramer, J.H., Weiner, M.W., Schuff, N., Norman, D., Mack, W.J., Willis, L., & Chui, H.C. (2001). MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology, 57, 2229–2235.CrossRefGoogle Scholar
O'Driscoll, G.A., Florencio, P.S., Gagnon, D., Wolff, A.V., Benkelfat, C., Mikula, L., Lal, S., & Evans, A.C. (2001). Amygdala-hippocampal volume and verbal memory in first-degree relatives of schizophrenic patients. Psychiatry Research, 107, 75–85.CrossRefGoogle Scholar
Petersen, R.C., Jack, C.R., Jr., Xu, Y.C., Waring, S.C., O'Brien, P.C., Smith, G.E., Ivnik, R.J., Tangalos, E.G., Boeve, B.F., & Kokmen, E. (2000). Memory and MRI-based hippocampal volumes in aging and AD. Neurology, 54, 581–587.CrossRefGoogle Scholar
Sass, K.J., Sass, A., Westerveld, M., Lencz, T., Novelly, R.A., Kim, J.H., & Spencer, D.D. (1992). Specificity in the correlation of verbal memory and hippocampal neuron loss: Dissociation of memory, language, and verbal intellectual ability. Journal of Clinical and Experimental Neuropsychology, 14, 662–672.CrossRefGoogle Scholar
Squire, L.R. (1992). Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychological Review, 99, 195–231.CrossRefGoogle Scholar
Squire, L.R. (1998). Memory systems. Comptes Rendus de L Academie des Sciences. Serie III, Sciences de la Vie, 321, 153–156.
Stuss, D.T. & Alexander, M.P. (2000). Executive functions and the frontal lobes: A conceptual view. Psychological Research, 63, 289–298.CrossRefGoogle Scholar
Williams, J.M. (1991). Memory Assessment Scales. Odessa: Psychological Assessment Resources.
Winocur, G., McDonald, R.M., & Moscovitch, M. (2001). Anterograde and retrograde amnesia in rats with large hippocampal lesions. Hippocampus, 11, 18–26.3.0.CO;2-5>CrossRefGoogle Scholar