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Longitudinal outcomes of very low birth weight: Neuropsychological findings


To investigate the effects of very low birth weight (VLBW, <1500 g) on the development of neuropsychological skills, we assessed 67 children with birth weight <750 g, 64 with birth weight 750–1499 g, and 67 term-born controls. Growth modeling of raw scores from mean ages 7–14 years revealed persistent VLBW sequelae. Even when adjusting for IQ, the <750 g group scored more poorly than the term-born group on measures of language processing, verbal list learning, and perceptual–motor and organizational abilities. This group also made slower age-related progress than the control group on tests of perceptual-motor and executive functions. Environmental factors moderated group differences in change on other cognitive measures. These results revealed further evidence for slower skill development in both VLBW groups relative to controls, as well as“catch-up” growth in the 750–1499 g group on some measures. The findings suggest age-related changes in the cognitive sequelae of VLBW that depend on the skill assessed, the degree of VLBW, and environmental factors. (JINS, 2004, 10, 149–163.)

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Reprint requests to: H. Gerry Taylor, Ph.D., Department of Pediatrics, Rainbow Babies & Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106-6038. E-mail:
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Anderson, M. (1998). Mental retardation general intelligence and modularity. Learning and Individual Differences, 10, 159178.

Anderson, V., Catroppa, C., Morse, S., Haritou, F., & Rosenfeld, M. (2000). Recovery of intellectual ability following traumatic brain injury in childhood: Impact of injury severity and age at injury. Pediatric Neurosurgery, 32, 282290.

Bendersky, M. & Lewis, M. (1994). Environmental risk, biological risk, and developmental outcome. Developmental Psychology, 30, 484494.

Booth, J.R., Burman, D.D., Van Santen, F.W., Harasaki, Y., Gitelman, D.R., Parrish, T.B., & Mesulam, M.M. (2001). The development of specialized brain systems in reading and oral-language. Child Neuropsychology, 7, 119141.

Botting, N., Powls, A., Cooke, R.W.I., & Marlow, N. (1998). Cognitive and educational outcome of very low birth weight children in early adolescence. Developmental Medicine and Child Neurology, 40, 652660.

Bradley, R.H., Whiteside, L., Mundfrom, D.J., Casey, P.H., Kelleher, K.J., & Pope, S.K. (1994). Early indications of resilience and their relation to experiences in the home environments of low birthweight, premature children living in poverty. Child Development, 65, 346360.

Breslau, N., Chilcoat, H., Del Dotto, J.E., Andreski, P., & Brown, G.G. (1996). Low birth weight and neurocognitive status at six years of age. Biological Psychiatry, 40, 389387.

Breslau, N., Chilcoat, H.D., Susser, E.S., Matte, T., Liang, K., & Peterson, E.L. (2001). Stability and change in children's intelligence quotient scores: A comparison of two socioeconomically disparate communities. American Journal of Epidemiology, 154, 711717.

Burchinal, M.R., Bailey, D.B., Jr., & Snyder, P. (1994). Using growth curve analysis to evaluate child changes in longitudinal investigations. Journal of Early Intervention, 18, 403423.

Burchinal, M.R., Roberts, J.E., Hooper, S., & Zeisel, S.A. (2000). Cumulative risk and early cognitive development: A comparison of statistical risk models. Developmental Psychology, 36, 793807.

Campbell, F.A., Pungello, E.P.Miller-Johnson, S., Burchinal, M., & Ramey, C.T. (2001). The development of cognitive and academic abilities: Growth curves from an early childhood educational experiment. Developmental Psychology, 37, 231242.

Carr, J. (1992). Longitudinal research in Down syndrome. International Review of Research in Mental Retardation, 18, 197223.

Carran, D., Scott, K., Shaw, K., & Beydoun, S. (1989). The relative risk of educational handicaps in two birth cohorts of normal and low birthweight disadvantaged children. Topics Early Childhood Special Education, 9, 1431.

Carta, J.J., Atwater, J.B., Greenwood, C.R., McConnell, S.R., McEvoy, M.A., & Williams, R. (2001). Effects of cumulative prenatal substance exposure and environmental risks on children's developmental trajectories. Journal of Clinical Child Psychology, 30, 327337.

Cohen, S.E., Beckwith, L., Parmelee, A.H., Sigman, M., Asarnow, R., & Espinosa, M.P. (1996). Prediction of low and normal school achievement in early adolescents born preterm. Journal of Early Adolescence, 16, 4670.

Cutting, L.E., Huang, G., Zeger, S., Koth, C.W., Thompson, R.E., & Denckla, M.B. (2002). Growth curve analyses of neuropsychological profiles in children with neurofibromatosis Type I: Specific cognitive tests remain “spared” and “impaired” over time. Journal of the International Neuropsychological Society, 8, 838846.

Denckla, M.G. (1974). Development of motor co-ordination in normal children. Developmental Medicine and Child Neurology, 16, 729741.

Dennis, M., Spiegler, B.J., Hoffman, H.J., Hendrick, E.B., Humphreys, R.P., & Becker, L.E. (1991). Brain tumors in children and adolescents: I. Effects on working, associative, and serial-order memory of IQ, age at tumor onset and age of tumor. Neuropsychologia, 29, 813827.

Donders, J. & Hoffman, N.M. (2002). Gender differences in learning and memory after pediatric traumatic brain injury. Neuropsychology, 16, 491499.

Eslinger, P.J. & Biddle, K.R. (2000). Adolescent neuropsychological development after early right prefrontal cortex damage. Developmental Neuropsychology, 18, 297329.

Espy, K.A., Molfese, V.J., & DiLalla, L.F. (2001). Effects of environmental measures on intelligence in young children: Growth curve modeling of longitudinal data. Merrill-Palmer Quarterly, 47, 4273.

Francis, D.J., Fletcher, J.M., Stuebing, K.K., Davidson, K.C., & Thompson, N.R. (1991). Analysis of change: Modeling individual growth. Journal of Consulting and Clinical Psychology, 59, 2737.

Frisk, V. & Whyte, H. (1994). The long-term consequences of periventricular brain damage on language and verbal memory. Developmental Neuropsychology, 10, 313333.

Goyen, T., Lui, K., & Woods, R. (1998). Visual–motor, visual–perceptual, and fine motor outcomes in very-low-birthweight children at 5 years. Developmental Medicine and Child Neurology, 40, 7681.

Hack, M., Breslau, N., Aram, D., Weissman, B., Klein, N., & Borawski-Clark, E. (1992). The effect of very low birthweight and social risk on neurocognitive abilities at school age. Journal of Developmental and Behavioral Pediatrics, 13, 412420.

Hack, M. & Fanaroff, A.A. (1999). Outcomes of children of extremely low birthweight and gestational age in the 1990s. Early Human Development, 53, 193218.

Hack, M., Klein, N., & Taylor, H.G. (1996b). School-age outcomes of children of extremely low birthweight and gestational age. Seminars in Neonatology, 1, 227288.

Halpern, D.F. (1997). Sex differences in intelligence: Implications for education. American Psychologist, 52, 10911102.

Hatton, D.D., Bailey, D.B., Jr., Burchinal, M.R., & Ferrell, K.A. (1997). Development growth curves of preschool children with vision impairments. Child Development, 68, 788806.

Hodapp, R.M., Dykens, E.M., Hagerman, R.J., Schreiner, R., Lachiewicz, A.M., & Leckman, J.F. (1990). Developmental implications of changing trajectories of IQ in males with Fragile X Syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 214219.

Huttenlocher, P.R. & Dabholkar, A.S. (1997). Regional differences in synaptogenesis in human cerebral cortex. Journal of Comparative Neurology, 387, 167178.

Jaccard, J. & Guilamo-Ramos, V. (2002). Analysis of variance frameworks in clinical child and adolescent psychology: Advanced issues and recommendations. Journal of Clinical Child Psychology, 31, 278294.

Kaufman, A. & Applegate, B. (1988). Short forms of K-ABC Mental Processing and Achievement Scales at age 4 to 12-1/2 years for clinical and screening purposes. Journal of Clinical Child Psychology, 17, 359369.

Klebanov, P.K., Brooks-Gunn, J., & McCormick, M.C. (1994). School achievement and failure in very low birthweight children. Developmental and Behavioral Pediatrics, 15, 248256.

Kowaleski-Jones, L. & Duncan, G.J. (1999). The structure of achievement and behavior across middle childhood. Child Development, 70, 930943.

Landry, S.H., Smith, K.E., Miller-Loncar, C.L., & Swank, P.R. (1997). Predicting cognitive-language and social growth curves from early maternal behaviors in children at varying degrees of biological risk. Developmental Psychology, 33, 10401053.

Landry, S.H., Smith, K.E., Miller-Loncar, C.L., & Swank, P.R. (1998). The relation of change in maternal interactive styles to the developing social competence of full-tern and preterm children. Child Development, 69, 105123.

Lorenz, J.M., Wooliever, D.E., Jetton, J.R., & Paneth, N. (1998). A quantitative review of mortality and developmental disability in extremely premature newborns. Archives of Pediatrics and Adolescent Medicine, 152, 425435.

Luciana, M., Lindeke, L., Georgieff, M., Mills, M., & Nelson, C.A. (1999). Neurobehavioral evidence for working-memory deficits in school-aged children with histories of prematurity. Developmental Medicine and Child Neurology, 41, 521533.

Luoma, L., Herrgard, E., & Martikainen, A. (1998). Neuropsychological analysis of the visuomotor problems in children born preterm at <32 weeks gestation: A 5-year prospective follow-up. Developmental Medicine and Child Neurology, 40, 2130.

McDermott, P.A. (1995). Sex, race, class, and other demographics as explanations for children's ability and adjustment: A national appraisal. Journal of School Psychology, 33, 7591.

Ment, L.R., Vohr, B., Allan, W., Katz, K.H., Schneider, K.C., Westerveld, M., Duncan, C.C., & Makuch, R.W. (2003). Change in cognitive function over time in very low-birth-weight infants. Journal of the American Medical Association, 289, 705711.

Miller, C.L., Landry, S.H., Smith, K.E., Wildin, S.R., Anderson, A.E., & Swank, P.R. (1995). Developmental change in the neuropsychological functioning of very low birth weight infants. Child Neuropsychology, 1, 224236.

Monset-Couchard, M., de Bethmann, O., & Kastler, B. (1996). Mid- and long-term outcome of 89 premature infants weighing less than 1,000 g at birth, all appropriate for gestation age. Biology of the Neonate, 70, 328338.

O'Callaghan, M.J., Burns, Y.R., Gray, P.H., Harvey, J.M., Mohay, H., Rogers, Y.M., & Tudehope, D.I. (1996). School performance of ELBW children: A controlled study. Developmental Medicine and Child Neurology, 38, 917926.

Perlman, J.M. (1998). White matter injury in the preterm infant: An important determination of abnormal neurodevelopment outcome. Early Human Development, 53, 99120.

Pungello, E.P., Kupersmidt, J.B., Burchinal, M.R., & Patterson, C.J. (1996). Environmental risk factors and children's achievement from middle childhood to early adolescence. Developmental Psychology, 32, 755767.

Rickards, A.L., Kelly, E.A., Doyle, L.W., & Callanan, C. (2001). Cognition, academic progress, behavior and self-concept at 14 years of very low birth weight children. Developmental and Behavioral Pediatrics, 22, 1118.

Roberts, J.E., Burchinal, M., Durham, M. (1999). Parents' report of vocabulary and grammatical development of African American preschoolers: Child and environmental associations. Child Development, 70, 92106.

Rourke, B.P. (1988). The syndrome of nonverbal learning disabilities: Developmental manifestations in neurological disease, disorder, and dysfunction. Clinical Neuropsychologist, 2, 293330.

Rutter, M. (2000). Psychosocial influences: Critiques, findings, and research needs. Development and Psychopathology, 12, 375405.

Rutter, M., Pickles, A., Murray, R., & Eaves, L. (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychological Bulletin, 127, 291324.

Saigal, S., Hoult, L.A., Streiner, D.L., Stoskopf, B.L., & Rosenbaum, P.L. (2000). School difficulties at adolescence in a regional cohort of children who were extremely low birthweight. Pediatrics, 105, 325331.

Schatz, J., Kramer, J.H., Ablin, A., & Matthay, K.K. (2000). Processing speed, working memory, and IQ: A developmental model of cognitive deficits following cranial radiation therapy. Neuropsychology, 14, 189200.

Schothorst, P.F. & van Engeland, H. (1996). Long-term behavioral sequelae of prematurity. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 175183.

Singer, J.D. (1998). Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models. Journal of Educational and Behavioral Statistics, 23, 323355.

Stevenson, C.J., Blackburn, P., & Pharoah, P.O.D. (1999). Longitudinal study of behaviour disorders in low birthweight infants. Archives of Disease in Childhood Fetal and Neonatal Edition, 81, F5F9.

Szatmari, P., Saigal, S., Rosenbaum, P., & Campbell, D. (1993). Psychopathology and adaptive functioning among extremely low birthweight children at eight years of age. Development and Psychopathology, 5, 345357.

Taylor, H.G., Hack, M., & Klein, N. (1998a). Attention deficits in children with <750 gm birth weight. Child Neuropsychology, 4, 2134.

Taylor, H.G., Klein, N., & Hack, M. (2000a). School-age consequences of birth weight less than 750 g: A review and update. Developmental Neuropsychology, 17, 289321.

Taylor, H.G., Klein, N., Minich, N., & Hack, M. (2000b). Middle school-age outcomes in children with very low birthweight. Child Development, 71, 14951511.

Taylor, H.G., Klein, N., Schatschneider, C., & Hack, M. (1998b). Predictors of early school age outcomes in very low birthweight children. Developmental and Behavioral Pediatrics, 19, 235243.

Taylor, H.G., Minich, N.M., Klein, N., & Hack, M. (2000c). Verbal memory deficits in children with <750 g birth weight. Child Neuropsychology, 6, 4963.

Taylor, H.G., Schatschneider, C., & Minich, N.M. (2000d). Longitudinal outcomes of Haemophilus influenzae meningitis in school-age children. Neuropsychology, 14, 509518.

Taylor, H.G., Schatschneider, C., Petrill, S., Barry, C.T., & Owens, C. (1996). Executive dysfunction in children with early brain disease: Outcomes post Haemophilus influenzae meningitis. Developmental Neuropsychology, 12, 3551.

Thompson, N.M., Francis, D.J., Stuebing, K.K., Fletcher, J.M., Ewing-Cobbs, L., Miner, M.E., Levin, H.S., & Eisenberg, H.M. (1994). Motor, visual-spatial, and somatosensory skills after closed head injury in children and adolescents: A study of change. Neuropsychology, 8, 333342.

Usher, R. & McLean, F. (1969). Intrauterine growth of live-born Caucasian infants at sea level: Standards obtained from measurements of 7 dimensions of infants born between 25 and 44 weeks of gestation. Pediatrics, 74, 901910.

Volpe, J.J. (1998). Brain injury in the premature infant: Overview of clinical aspects, neuropathology, and pathogenesis. Seminars in Pediatric Neurology, 5, 135151.

Waber, D.P. & McCormick, M.C. (1995). Late neuropsychological outcomes in preterm infants of normal IQ: Selective vulnerability of the visual system. Journal of Pediatric Psychology, 20, 721735.

Wolke, D. & Meyer, R. (1999). Cognitive status, language attainment, and prereading skills of 6-year-old very preterm children and their peers: The Bavarian Longitudinal Study. Developmental Medicine and Child Neurology, 41, 94109.

Zelkowitz, P., Papageorgiou, A., Zelazo, P.R., & Weiss, M.J.S. (1995). Behavioral adjustment in very low and normal birth weight children. Journal of Clinical Child Psychology, 24, 2130.

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