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Syntactic language processing: ERP lesion data on the role of the basal ganglia

  • SONJA A. KOTZ (a1) (a2), STEFAN FRISCH (a1) (a3), D. YVES VON CRAMON (a1) (a2) and ANGELA D. FRIEDERICI (a1)
Abstract

The role of the basal ganglia in syntactic language processing was investigated with event-related brain potentials in fourteen neurologically impaired patients. Seven of these patients had basal ganglia lesions while 7 other patients primarily had lesions of the left temporo–parietal region excluding the basal ganglia. All patients listened to sentences that were either correct or included a verb argument structure violation. In previous experiments this type of violation elicited a biphasic pattern of an N400–P600 complex in young healthy participants. While the N400 may result from incorrect semantic-thematic role assignment, the P600 reflects the fact that verb information does not license the syntactic structure at present. Results of the patient experiment revealed a double dissociation: patients with left temporo–parietal lesions only show a P600, whereas patients with lesions of the basal ganglia showed no P600, but a negativity with extended duration that resembled an N400. The latter pattern not only confirms previous reports that the basal ganglia modulate the P600 but extends these results by showing that the N400 as a late semantic–thematic integration process appears partially modulated by the basal ganglia. (JINS, 2003, 9, 1053–1060.)

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Corresponding author
Reprint requests to: Sonja A. Kotz, Max-Planck-Institute of Cognitive Neuroscience, PO Box 500 355, D-04303 Leipzig, Germany. E-mail: kotz@cns.mpg.de
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REFERENCES

Alexander, M.P., Naeser, M.A., & Palumbo, C.L. (1987). Correlations of subcortical CT lesion sites and aphasic profiles. Brain, 110, 961991.
Breitenstein, C., Daum, I., & Ackermann, H. (1998). Emotional processing following cortical and subcortical brain damage: Contribution of the fronto–striatal circuitry. Behavioural Neurology, 11, 2942.
Breitenstein, C., Van Lancker, D., Daum, I., & Waters, C. (2001). Impaired perception of vocal emotions in Parkinson's disease: Influence of speech time processing and executive functioning. Brain and Cognition, 45, 277314.
Cappa, S.F. & Abutalebi, J. (1999). Subcortical aphasia. In F. Fabbro (Ed.), The concise encyclopedia of language pathology (pp. 319327). Oxford, UK: Pergamon Press
Coulson, S., King, J., & Kutas, M. (1998). Expect the unexpected: Event-related brain response to morphosyntactic violations. Language and Cognitive Processes, 13, 2158.
Crosson, B. (1999). Subcortical mechanisms in language: Lexical–semantic mechanisms and the thalamus. Brain and Cognition, 40, 414438.
Friederici, A.D. (1995). The time course of syntactic activation during language processing: A model based on neuropsychological and neurophysiological data. Brain and Language, 50, 259281.
Friederici, A.D. (1999). The neurobiology of language comprehension. In A.D. Friederici (Ed.), Language comprehension: A biological perspective (2nd ed., pp. 265304). Berlin: Springer.
Friederici, A.D. (2002). Towards a neural basis of auditory sentence processing. Trends in Cognitive Sciences, 6, 7884.
Friederici, A.D., & Frisch, S. (2000). Verb-argument structure processing: The role of verb-specific and argument-specific information. Journal of Memory and Language, 43, 476507.
Friederici, A.D., Kotz, S.A., Werheid, K., Hein, G., & von Cramon, D.Y. (2003). Syntactic comprehension in Parkinson's disease: Investigating early and late integrational processes using ERPs. Neuropsychology, 17, 133142.
Friederici, A.D., von Cramon, D.Y., & Kotz, S.A. (1999). Language related brain potentials in patients with cortical and subcortical left hemisphere lesions. Brain, 122, 10331047.
Frisch, S., Hahne, A., & Friederici, A.D. (2000). ERP evidence for the priority of phrase structure information over argument structure information in sentence processing. Journal of Cognitive Neuroscience (Suppl. 12) 51.
Frisch, S., Kotz, S.A.., Friederici, A.D., & von Cramon, D.Y. (2003). Why the P600 is not just a P300. Electroencephalography and Clinical Neurophysiology, 114, 336340.
Frisch, S., Schlesewsky, M., Saddy, D., & Alpermann, A. (2002). The P600 as an indicator of syntactic ambiguity. Cognition, 85, B83B92.
Goodglass, H. (1993). Understanding aphasia. San Diego, CA: Academic Press.
Gotham, A.M., Brown, R.G., & Marsden, C.D. (1988). “Frontal” cognitive function in patients with Parkinson's disease “on” and “off” levodopa. Brain, 111, 299321.
Grossman, M., Carvell, S., Gollomp, S., Stern, M.B., Reivich, M., Morrison, D., Alavi, A., & Hurtig, H.I. (1993). Cognitive and physiological substrates of impaired sentence processing in Parkinson's disease. Journal of Cognitive Neuroscience, 5, 480498.
Grossman, M., Carvell, S., Gollomp, S., Stern, M.B., Vernon, R.N., & Hurtig, H.I. (1991). Sentence comprehension and praxis deficits in Parkinson's disease. Neurology, 41, 16201626.
Grossman, M., Carvell, S., Stern, M.B., Gollomp, S., & Hurtig, H.I. (1992). Sentence comprehension in Parkinson's disease: The role of attention and memory. Brain and Language, 42, 347384.
Grossman, M., Zurif, E., Lee, C., Prather, P., Kalmanson, J., Stern, M.B., & Hurtig, H.I. (2002). Information processing speed and sentence comprehension in Parkinson's disease. Neuropsychology, 16, 174181.
Gunter, T.C., Stowe, L.A., & Mulder, G. (1997). When syntax meets semantics. Psychophysiology, 34, 660676.
Hahne, A. & Friederici, A.D. (1999). Electrophysiological evidence for two steps in syntactic analysis: Early automatic and late controlled processes. Journal of Cognitive Neuroscience, 11, 194205.
Kaan, E., Harris, A., Gibson, G., & Holcomb, P.J. (2000). The P600 as an index of syntactic integration difficulty. Language and Cognitive Processes, 15, 159201.
Kotz, S.A. & Friederici, A.D. (2003). Electrophysiology of normal and pathological language processing. Journal of Neurolinguistics, 16, 4358.
Kotz, S.A., Meyer, M., Alter, K., Besson, M., von Cramon, D.Y., & Friederici, A. (in press). On the lateralization of emotional prosody: An fMRI investigation. Brain and Language.
Lieberman, P. (2001). Human language and our reptilian brain: The subcortical bases of speech, syntax, and thought. Perspectives in Biology and Medicine, 4, 3251.
Lieberman, P., Friedman, J., & Feldman, L.S. (1990). Syntactic deficits in Parkinson's disease. Journal of Nervous and Mental Disorders, 178, 360365.
Lieberman, P., Kako, E., Friedman, J., Tajchman, G., Feldman, L.S., & Jiminez, E.B. (1992). Speech production, syntax comprehension, and cognitive deficits in Parkinson's disease. Brain and Language, 43, 169189.
Marsden, C.D. & Obeso, J.A. (1994). The functions of the basal ganglia and the paradox of sterotaxic surgery in Parkinson's disease. Brain, 117, 877897.
Mortimer, J.A., Pirozzolo, F.J., Hansch, E.C., & Webster, D.D. (1982). Relationship of motor symptoms to intellectual deficits in Parkinson disease. Neurology, 32, 133137.
Nadeau, S.E. & Crosson, B. (1997). Subcortical aphasia. Brain and Language, 58, 403409.
Natsopoulos, D., Grouios, G., Bostantzopoulou, G., Mentenopoulos, G., Katsarou, Z., & Logothetis, J. (1993). Algorithmic and heuristic strategies in comprehension of complement clauses by patients with Parkinson's disease. Neuropsychology, 31, 951964.
Osterhout, L., Holcomb, P.J., & Swinney, D.A. (1994). Brain potentials elicited by garden-path sentences: Evidence of the application of verb information during parsing. Journal of Experimental Psychology: Learning, Memory and Cognition, 20, 786803.
Osterhout, L. (1997). On the brain response to syntactic anomalies—manipulations of word position and word class reveal individual differences. Brain & Language, 59, 494522.
Pell, M.D. (2002). Surveying emotional prosody in the brain: Some key landmarks and new directions. In B. Bel and I. Marlein (Eds.), Speech prosody, Proceedings of the 1st International Conference on Speech Prosody, Aix-en-Provence, France (pp. 7782).
Pfeifer, E., Novagk, R., & Maess, B. (1995). Software for EEG/ERP evaluation. In A.D. Friederici (Ed.), Max Planck Institute of Cognitive Neuroscience Leipzig annual report (pp. 5155). Leipzig, Germany: Max Planck Institute of Cognitive Neuroscience.
Pickett, E.R., Kuniholm, E., Protopapas, A., Friedman, J., & Lieberman, P. (1998). Selective motor, syntax and cognitive deficits associated with bilateral damage to the head of the caudate nucleus and the putamen: A single case study. Neuropsychologia, 36, 173188.
Rao, S.M., Mayes, A.R., & Harrington, D.L (2001). The evolution of brain activation during temporal processing. Nature Neuroscience, 4, 317323.
Robin, D.A. & Schienberg, S. (1990). Subcortical lesions and aphasia. Journal of Speech and Hearing Disorders, 55, 90100.
Schubotz, R.I., Friederici, A.D., & von Cramon, D.Y. (2000). Time perception and motor timing: A common cortical and subcortical basis revealed by fMRI. Neuroimage, 11, 112.
Tyler, L.K. & Marslen-Wilson, W.D. (1986). The effects of context on the recognition of polymorphemic words. Journal of Memory and Language, 25, 741752.
Ullman, M.T. (2001). A neurocognitive perspective on language: The declarative/procedural model. Neuroscience, 2, 717726.
Ullman, M.T., Corkin, S., Coppola, M., Hickok, G., Growdon, J.H., Koroshetz, W.J., & Pinker, S. (1997). A neural dissociation within language: Evidence that the mental dictionary is part of declarative memory, and that grammatical rules are processed by the procedural system. Journal of Cognitive Neuroscience, 9, 266276.
Wallesch, C.W. & Papagno, C. (1988). Subcortical aphasia. In F.C. Rose, R. Whurr, & M.A. Wyke (Eds.), Aphasia (pp. 256287) London: Whurr Publishers.
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