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Electron Microscopy as an Emerging Analytical Tool for Characterizing Biopharmaceuticals

Published online by Cambridge University Press:  23 September 2015

Bridget Carragher
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
Anette Schneemann
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
Joyce J. Sung
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
Sean K. Mulligan
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
Jeffrey A. Speir
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
Kat On
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
Joel Quispe
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
Clinton S. Potter
Affiliation:
NanoImaging Services, Inc., San Diego, CAUSA
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Abstract

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Copyright © Microscopy Society of America 2015 

References

[1] Zhao, Q, et al. Characterization of virus-like particles in GARDASIL(R) by cryo transmission electron microscopy. Hum Vaccine Immunother 10 (2013), 1.Google ScholarPubMed
[2] Mulder, AM, et al. Toolbox for non-intrusive structural and functional analysis of recombinant VLP based vaccines: a case study with hepatitis B vaccine. PloS One 7 (2012), 4.CrossRefGoogle ScholarPubMed
[3] Fox, CB, et al. Cryogenic transmission electron microscopy of recombinant tuberculosis vaccine antigen with anionic liposomes reveals formation of flattened liposomes. Int J Nanomedicine 9 (2014), 1367.CrossRefGoogle ScholarPubMed
[4] Correia, I, et al. The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen. MAbs 5 (2013), 364.CrossRefGoogle ScholarPubMed
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