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The Hair Follicle Bulge: A Niche for Adult Stem Cells

  • Hilda Amalia Pasolli (a1)
Abstract

Adult stem cells (SCs) are essential for tissue homeostasis and wound repair. They have the ability to both self-renew and differentiate into multiple cell types. They often reside in specialized microenvironments or niches that preserve their proliferative and tissue regenerative capacity. The murine hair follicle (HF) has a specialized and permanent compartment—the bulge, which safely lodges SCs and provides the necessary molecular cues to regulate their function. The HF undergoes cyclic periods of destruction, regeneration, and rest, making it an excellent system to study SC biology.

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Corresponding author. E-mail: pasolla@rockefeller.edu
References
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Abe, K., Hashiyama, M., MacGregor, G. & Yamamura, K. (1996). Purification of primordial germ cells from TNAPbeta-geo mouse embryos using FACS-gal. Dev Biol 180(2), 468472.
Blanpain, C. & Fuchs, E. (2009). Epidermal homeostasis: A balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 10(3), 207217.
Blanpain, C., Lowry, W.E., Geoghegan, A., Polak, L. & Fuchs, E. (2004). Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118(5), 635648.
Claudinot, S., Nicolas, M., Oshima, H., Rochat, A. & Barrandon, Y. (2005). Long-term renewal of hair follicles from clonogenic multipotent stem cells. Proc Natl Acad Sci USA 102(41), 1467714682.
Cotsarelis, G., Sun, T.T. & Lavker, R.M. (1990). Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61(7), 13291337.
Dry, F. (1926). The coat of the mouse (Mus musculus). J Genet 16(3), 287340.
Fuchs, E. (2007). Scratching the surface of skin development. Nature 445(7130), 834842.
Fuchs, E. & Nowak, J.A. (2008). Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol 73, 333350.
Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H.A., Stokes, N., Dela Cruz-Racelis, J. & Fuchs, E. (2009). A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4(2), 155169.
Hardy, M.H. (1992). The secret life of the hair follicle. Trends Genet 8(2), 5561.
Horsley, V., Aliprantis, A.O., Polak, L., Glimcher, L.H. & Fuchs, E. (2008). NFATc1 balances quiescence and proliferation of skin stem cells. Cell 132, 299310.
Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A. & Fuchs, E. (2006). Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell 126(3), 597609.
Hsu, C.L., Hoepting, C.A., Fuchs, M., Shelton, A.M. & Nault, B.A. (2010). Temporal dynamics of iris yellow spot virus and its vector, Thrips tabaci (Thysanoptera: Thripidae), in seeded and transplanted onion fields. Environ Entomol 39(2), 266277.
Hsu, Y.C., Pasolli, H.A. & Fuchs, E. (2011). Dynamics between stem cells, niche, and progeny in the hair follicle. Cell 144(1), 92105.
Ito, M., Kizawa, K., Hamada, K. & Cotsarelis, G. (2004). Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen. Differentiation 72(9-10), 548557.
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R.J. & Cotsarelis, G. (2005). Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med 11(12), 13511354.
Jaks, V., Barker, N., Kasper, M., van Es, J.H., Snippert, H.J., Clevers, H. & Toftgard, R. (2008). Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet 40(11), 12911299.
Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D.E., Albelda, S. & Cotsarelis, G. (1999). Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc 4(3), 296301.
Morris, R.J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J.S., Sawicki, J.A. & Cotsarelis, G. (2004). Capturing and profiling adult hair follicle stem cells. Nat Biotechnol 22(4), 411417.
Muller-Rover, S., Handjiski, B., van der Veen, C., Eichmuller, S., Foitzik, K., McKay, I.A., Stenn, K.S. & Paus, R. (2001). A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 117(1), 315.
Muller-Rover, S., Tokura, Y., Welker, P., Furukawa, F., Wakita, H., Takigawa, M. & Paus, R. (1999). E- and P-cadherin expression during murine hair follicle morphogenesis and cycling. Exp Dermatol 8(4), 237246.
Nguyen, H., Rendl, M. & Fuchs, E. (2006). Tcf3 governs stem cell features and represses cell fate determination in skin. Cell 127(1), 171183.
Oliver, R.F. & Jahoda, C.A.B. (1988). Dermal-epidermal interactions. Clin Dermatol 6(4), 7482.
Panteleyev, A.A., Jahoda, C.A. & Christiano, A.M. (2001). Hair follicle predetermination. J Cell Sci 114(Pt 19), 34193431.
Rhee, H., Polak, L. & Fuchs, E. (2006). Lhx2 maintains stem cells character in hair follicles. Science 312, 19461949.
Stenn, K.S. & Paus, R. (2001). Controls of hair follicle cycling. Physiol Rev 81(1), 449494.
Trempus, C.S., Morris, R.J., Bortner, C.D., Cotsarelis, G., Faircloth, R.S., Reece, J.M. & Tennant, R.W. (2003). Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120(4), 501511.
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W.E., Rendl, M. & Fuchs, E. (2004). Defining the epithelial stem cell niche in skin. Science 303(5656), 359363.
Unna, P.G. (1876). Beitrage zur histologie und entwicklungsgeschichte der menschlichen oberhaut und ihrer anhangsgebilde. Arch Mikroskop Anat Entwicklungsmech 12, 665741.
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Microscopy and Microanalysis
  • ISSN: 1431-9276
  • EISSN: 1435-8115
  • URL: /core/journals/microscopy-and-microanalysis
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