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New Method to Quantify Angiogenesis in vivo Using Multi-photon Imaging

Published online by Cambridge University Press:  15 September 2009

B. J. Herron
Affiliation:
Wadsworth Center, New York State Department of Health, PO Box 509, Albany, NY 12201 Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, Albany, NY 12201
J. S. Smith
Affiliation:
Wadsworth Center, New York State Department of Health, PO Box 509, Albany, NY 12201
R. W. Cole*
Affiliation:
Wadsworth Center, New York State Department of Health, PO Box 509, Albany, NY 12201 Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, Albany, NY 12201
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Efforts to understand the basic mechanisms of angiogenesis, that is, the formation of new blood vessels from existing vasculature, have been limited by the methods that are currently used to measure vessel growth. Although in vivo assays provide the best environment in which to track angiogenesis, inherent difficulties in obtaining reproducible data limit the power of this approach. Limitations include: environmental variations between experimental animals, induction of inflammatory responses by surgical methods, and labor-intensive blood vessel quantification procedures. A better assay would measure vessel growth in one animal at multiple time points and would focus on minimization of artifacts induced by experimental manipulation.

Type
Biological Applications
Copyright
Copyright © Microscopy Society of America 2009
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