Skip to main content
×
Home
    • Aa
    • Aa

Novel infection-resistant surface coatings: A bioengineering approach

  • Xiaojuan Khoo (a1) and Mark W. Grinstaff (a2)
Abstract
Abstract

Despite modern advancements in sterilization and aseptic procedures, bacterial infections remain a major and significant impediment to the long-term success of medical implants and devices, including catheters, artificial prosthetics, and subcutaneous sensors. It has been estimated that upward of 60% of nosocomial, or hospital-acquired, infections are associated with implants, with an estimated one million cases per year in the United States alone. Current treatment regimens primarily rely on the systemic administration of antibiotics or local administration through irrigation of the surgical site. However, after decades of prophylactic antibiotic use, high infection rates continue to persist, particularly with the emergence of drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). Consequently, recent research efforts have focused on the use of non-antibiotic-based coatings to inhibit bacteria colonization and subsequent biofilm formation on implant surfaces. In particular, advancements in surface treatment strategies and ongoing development of new antimicrobial agents have led to encouraging progress in the design of better coatings. Here, we present and discuss representative examples of novel surface engineering approaches to address device-associated infections, focusing in particular on coatings that can be easily administered onto implant material surfaces.

Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.R.O. Darouiche , N. Engl. J. Med. 350, 1422 (2004).

2.J.W. Costerton , P.S. Stewart , E.P. Greenberg , Science 284, 1318 (1999).

3.W.M.J. Dunne , Clin. Microbiol. Rev. 15, 155 (2002).

8.J.G. Hendriks , J.R. van Hornm , H.C. van der Meim , H.J. Busscherm , Biomaterials 25, 545 (2004).

9.D.C. Vinh , J.M. Embil , J. Long-Term Eff. Med. Implants 15, 467 (2005).

10.A.L. Panlilio , D.H. Culver , R.P. Gaynes , S. Banerjee , T.S. Henderson , J.S. Tolson , W.J. Martone , Infect. Control Hosp. Epidemiol. 13, 582 (1992).

11.K. Hiramatsu , H. Hanaki , T. Ino , K. Yabuta , T. Oguri , F.C. Tenover , J. Antimicrob. Chemother. 40, 2 (1997).

12.T.L. Smith , M.L. Pearson , K.R. Wilcox , C. Cruz , M.V. Lancaster , B. Robinson-Dunn , F.C. Tenover , M.J. Zervos , J.D. Band , E. White , W.R. Jarvis , N. Engl. J. Med. 340, 493 (1999).

14.V. Alt , A. Bitschnau , J. Osterling , A. Sewing , C. Meyer , R. Kraus , S.A. Meissner , S. Wenisch , E. Domann , R. Schnettler , Biomaterials 27, 4627 (2006).

15.M. Lucke , G. Schmidmaier , S. Sadoni , B. Wildemann , R. Schiller , N.P. Haas , M. Raschke , Bone 32, 521 (2003).

16.C.S. Adams , V. Antoci Jr., G. Harrison , P. Patal , T.A. Freeman , I.M. Shapiro , J. Parvizi , N.J. Hickok , S. Radin , P. Ducheyne , J. Orthop. Res. 27, 701 (2009).

19.V. Antoci Jr., C.S. Adams , J. Parvizi , H.M. Davidson , R.J. Composto , T.A. Freeman , E. Wickstrom , P. Ducheyne , D. Jungkind , I.M. Shapiro , N.J. Hickok , Biomaterials 29, 4684 (2008).

20.H. van de Belt , D. Neut , W. Schenk , J.R. van Horn , H.C. van der Mei , H.J. Busscher , Acta Orthop. Scand. 72, 557 (2001).

21.L. Zhao , P.K. Chu , Y. Zhang , Z. Wu , J. Biomed. Mater. Res. B: Appl. Biomater. 91B, 470 (2009).

22.T.J. Berger , J.A. Spadaro , S.E. Chapin , R.O. Becher , Antimicrob. Agents Chemother. 9, 357 (1976).

23.B.J. Nablo , T.-Y. Chen , M.H. Schoenfisch , J. Am. Chem. Soc. 123, 9712 (2001).

24.I.A. Rojas , J.B. Slunt , D.W. Grainger , J. Controlled Release 63, 175 (2000).

25.T. Nuryastuti , H.C. van der Mei , H.J. Busscher , S. Iravati , A.T. Aman , B.P. Krom , Appl. Environ. Microbiol. 75, 6850 (2009).

26.S.L. Percival , P.G. Bowler , D. Russell , J. Hosp. Infect. 60, 1 (2005).

27.A. Melaiye , W.J. Youngs , Expert Opin. Ther. Patents 15, 125 (2005).

28.J. Hardes , H. Ahrens , C. Gebert , A. Streitbuerger , H. Buerger , M. Erren , A. Gunsel , C. Wedemeyer , G. Saxler , W. Winkelmann , G. Gosheger , Biomaterials 28, 2869 (2007).

29.M. Bosetti , A. Masse , E. Tobin , M. Cannas , Biomaterials 23, 887 (2002).

30.G. Gosheger , J. Hardes , H. Ahrens , A. Streitburger , H. Buerger , M. Erren , A. Gunsel , F.H. Kemper , W. Winkelmann , C. von Eiff , Biomaterials 25, 5547 (2004).

31.A. Ewald , S. Gluckermann , R. Thull , U. Gbureck , Biomed. Eng. Online 5, 22 (2006).

32.T. Bechert , M. Boswald , S. Lugauer , A. Regenfus , J. Greil , J.P. Guggenbichler , Infection 27, 24 (1999).

34.R.E. Gilbert , M. Harden , Curr. Opin. Infect. Dis. 21, 235 (2008).

35.S. Inouye , T. Takizawa , H. Yamaguchi , J. Antimicrob. Chemother. 47, 565 (2001).

36.Y. Inoue , A. Shiraishi , T. Hada , K. Hirose , H. Hamashima , J. Shimada , FEMS Microbiol. Lett. 237, 325 (2004).

37.F. Gomes , P. Teixeira , J. Azeredo , R. Oliveira , Curr. Microbiol. 59, 118 (2009).

38.K. Bazaka , M.V. Jacob , V.K. Truong , F. Wang , W.A.A. Pushpamali , J.Y. Wang , A.V. Ellis , C.C. Berndt , R.J. Crawford , E.P. Ivanova , Biomacromolecules 11, 2016 (2010).

39.X. Wang , S. Qiu , X. Yao , T. Tang , K. Dai , Z.A. Zhu , J. Orthop. Res. 27, 1487 (2009).

40.H.-H. Yu , K.-J. Kim , J.-D. Cha , H.-K. Kim , Y.-E. Lee , N.-Y. Choi , Y.-O. You , J. Med. Food 8, 454 (2005).

42.H.G. Boman , Annu. Rev. Immunol. 13, 61 (1995).

43.H. Komatsuzawa , K. Ouhara , S. Yamada , T. Fujiwara , K. Sayama , K. Hashimoto , M. Sugai , J. Pathol. 208, 249 (2006).

44.M. Zasloff , Nature 415, 389 (2002).

45.S.L. Haynie , G.A. Crum , B.A. Doele , Antimicrob. Agents Chemother. 39, 301 (1995).

46.D. Liu , S. Choi , B. Chen , R.J. Doerksen , D.J. Clements , J.D. Winkler , M.L. Klein , W.F. DeGrado , Angew. Chem. Int. Ed. 43, 1158 (2004).

47.B.P. Mowery , S.E. Lee , D.A. Kissounko , R.F. Epand , R.M. Epand , B. Weisblum , S.S. Stahl , S.H. Gellman , J. Am. Chem. Soc. 129, 15474 (2007).

48.G.N. Tew , D. Liu , B. Chen , R.J. Doerksen , J. Kaplan , P.J. Carroll , M.L. Klein , W.F. DeGrado , Proc. Natl. Acad. Sci. U.S.A. 99, 5110 (2002).

49.G.N. Tew , R.W. Scott , M.L. Klein , W.F. DeGrado , Acc. Chem. Res. 43, 30 (2009).

50.Z. Shi , K.G. Neoh , E.T. Kang , W. Wang , Biomaterials 27, 2440 (2006).

51.E.M. Hetrick , M.H. Schoenfisch , Biomaterials 28, 1948 (2007).

52.B.J. Nablo , A.R. Rothrock , M.H. Schoenfisch , Biomaterials 26, 917 (2005).

53.J. Lin , S. Qiu , K. Lewis , A.M. Klibanov , Biotechnol. Progr. 18, 1082 (2002).

54.B. Gottenbos , H.C. van der Mei , F. Klatter , P. Nieuwenhuis , H.J. Busscher , Biomaterials 23, 1417 (2002).

55.J.C. Tiller , C.-J. Liao , K. Lewis , A.M. Klibanov , Proc. Natl. Acad. Sci. U.S.A. 98, 5981 (2001).

56.J.C. Tiller , S.B. Lee , K. Lewis , A.M. Klibanov , Biotechnol. Bioeng. 79, 465 (2002).

57.D. Campoccia , L. Montanaro , C.R. Arciola , Biomaterials 27, 2331 (2006).

58.S.E. Tebbs , A. Sawyer , T.S.J. Elliott , Br. J. Anaesth. 72, 587 (1994).

59.R.L. Taylor , J. Verran , G.C. Lees , A.J.P. Ward , J. Mater. Sci. - Mater. Med. 9, 17 (1998).

60.Y. Wu , J.P. Zitelli , K.S. TenHuisen , X. Yu , M.R. Libera , Biomaterials 32, 951 (2011).

61.J. Verran , C.J. Maryan , J. Prosthetic Dentistry 77, 535 (1997).

62.R.J. Koerner , L.A. Butterworth , I.V. Mayer , R. Dasbach , H.J. Busscher , Biomaterials 23, 2835 (2002).

64.W.-K. Liu , S.E. Tebbs , P.O. Byrne , T.S.J. Elliott , J. Infect. 27, 261 (1993).

65.G. Harkes , J. Feijen , J. Dankert , Biomaterials 12, 853 (1991).

66.J.M. Yang , H.T. Lin , T.H. Wu , C.-C. Chen , J. Appl. Polym. Sci. 90, 1331 (2003).

67.J.N. Baumgartner , C.Z. Yang , S.L. Cooper , Biomaterials 18, 831 (1997).

68.H.C. Van Der Mei , A.J. Léonard , A.H. Weerkamp , P.G. Rouxhet , H.J. Busscher , Colloids Surf. 32, 297 (1988).

69.W.G. Pitt , R.N. Morris , M.L. Mason , M.W. Hall , Y. Luo , G.D. Prestwich , J. Biomed. Mater. Res. A 68A, 95 (2004).

70.M. Morra , C. Cassineli , J. Biomater. Sci., Polym. Ed. 10, 1107 (1999).

72.A. Abu El-Asrar , A. Shibl , K. Tabbara , S. Al-Kharashi , Int. Ophthalmol. 21, 71 (1997).

73.P. Appelgren , U. Ransjo , L. Bindslev , F. Espersen , O. Larm , Crit. Care Med. 24, 1482 (1996).

74.D. Lange , C.N. Elwood , K. Choi , K. Hendlin , M. Monga , B.H. Chew , J. Urol. 182, 1194 (2009).

75.M.J. Bridgett , M.C. Davies , S.P. Denyer , P.R. Eldridge , Biomaterials 14, 184 (1993).

76.M.M. Tunney , S.P. Gorman , Biomaterials 23, 4601 (2002).

77.S.E. Tebbs , T.S.J. Elliott , Eur. J. Clin. Microbiol. Infect. Dis. 13, 111 (1994).

78.K. Glasmästar , C. Larsson , F. Höök , B. Kasemo , J. Colloid Interface Sci. 246, 40 (2002).

79.P. Kingshott , H.J. Griesser , Curr. Opin. Solid State Mater. Sci. 4, 403 (1999).

81.S.K. Hendricks , C. Kwok , M. Shen , T.A. Horbett , B.D. Ratner , J.D. Bryers , J. Biomed. Mater. Res. 50, 160 (2000).

82.M. Shen , Y.V. Pan , M.S. Wagner , K.D. Hauch , D.G. Castner , B.D. Ratner , T.A. Horbett , J. Biomater. Sci., Polym. Ed. 12, 961 (2001).

83.T.M. Blättler , S. Pasche , M. Textor , H.J. Griesser , Langmuir 22, 5760 (2006).

84.M. Heuberger , T. Drobek , N.D. Spencer , Biophys. J. 88, 495 (2005).

86.A. Roosjen , J. de Vries , H.C. van der Mei , N. Willem , H.J. Busscher , J. Biomed. Mater. Res. B: Appl. Biomater. 73B, 347 (2005).

87.A. Roosjen , H.C. van der Mei , H.J. Busscher , W. Norde , Langmuir 20, 10949 (2004).

88.K.D. Park , Y.S. Kim , D.K. Han , Y.H. Kim , E.H.B. Lee , H. Suh , K.S. Choi , Biomaterials 19, 851 (1998).

89.P. Kingshott , J. Wei , D. Bagge-Ravn , N. Gadegaard , L. Gram , Langmuir 19, 6912 (2003).

90.G.P. Lopez , B.D. Ratner , C.D. Tidwell , C.L. Haycox , R.J. Rapoza , T.A. Horbett , J. Biomed. Mater. Res. 26, 415 (1992).

91.A.R. Denes , E.B. Somers , A.C.L. Wong , F. Denes , J. Appl. Polym. Sci. 81, 3425 (2001).

92.R.G. Chapman , E. Ostuni , M.N. Liang , G. Meluleni , E. Kim , L. Yan , G. Pier , H.S. Warren , G.M. Whitesides , Langmuir 17, 1225 (2001).

93.E.O. Ostuni , R.G. Chapman , M.N. Liang , G. Meluleni , G. Pier , D.E. Ingber , G.M. Whitesides , Langmuir 17, 6336 (2001).

94.S. Hou , E.A. Burton , K.A. Simon , D. Blodgett , Y.Y. Luk , D. Ren , Appl. Environ. Microbiol. 73, 4300 (2007).

95.Z. Yang , J.A. Galloway , H. Yu , Langmuir 15, 8405 (1999).

96.J.D. Cox , M.S. Curry , S.K. Skirboll , P.L. Gourley , D.Y. Sasaki , Biomaterials 23, 929 (2002).

97.J.L. Dalsin , B.H. Hu , B.P. Lee , P.B. Messersmith , J. Am. Chem. Soc. 125, 4253 (2003).

98.J.H. Waite , M.L. Tanzer , Science 212, 1038 (1981).

99.M. Yu , J. Hwang , T.J. Deming , J. Am. Chem. Soc. 121, 5825 (1999).

100.J.L. Dalsin , L. Lin , S. Tosatti , J. Voros , M. Textor , P.B. Messersmith , Langmuir 21, 640 (2005).

101.R. Ko , P.A. Cadieux , J.L. Dalsin , B.P. Lee , C.N. Elwood , H. Razvi , J. Endourol. 22, 1153 (2008).

102.X. Fan , L. Lin , P.B. Messersmith , Biomacromolecules 7, 2443 (2006).

103.H. Lee , K.D. Lee , K.B. Pyo , S.Y. Park , H. Lee , Langmuir 26, 3790 (2010).

104.J.A. Neff , K.D. Caldwell , P.A. Tresco , J. Biomed. Mater. Res. 40, 511 (1998).

105.J.A. Neff , P.A. Tresco , K.D. Caldwell , Biomaterials 20, 2377 (1999).

106.M.R. Nejadnik , H.C. van der Mei , H.J. Busscher , W. Norde , Appl. Environ. Microbiol. 74, 916 (2008).

107.V.A. Liu , W.E. Jastromb , S.N. Bhatia , J. Biomed. Mater. Res. 60, 126 (2002).

108.K. Vacheethasanee , R.E. Marchant , J. Biomed. Mater. Res. 50, 302 (2000).

109.L.G. Harris , S. Tosatti , M. Wieland , M. Textor , R.G. Richards , Biomaterials 25, 4135 (2004).

113.M. Sarikaya , C. Tamerler , A.K.J. Jen , K. Schulten , F. Baneyx , Nat. Mater. 2, 577 (2003).

114.K.I. Sano , K. Shiba , J. Am. Chem. Soc. 125, 14234 (2003).

115.S.R. Meyers , P.T. Hamilton , E.B. Walsh , D.J. Kenan , M.W. Grinstaff , Adv. Mater. 19, 2492 (2007).

116.A.B. Sanghvi , K.P.H. Miller , A.M. Belcher , C.E. Schmidt , Nat. Mater. 4, 496 (2005).

117.X. Huang , S. Zauscher , B. Klitzman , G.A. Truskey , W.M. Reichert , D.J. Kenan , M.W. Grinstaff , Ann. Biomed. Eng. 38, 1965 (2010).

118.D.J. Kenan , E.B. Walsh , S.R. Meyers , G.A. O’Toole , E.G. Carruthers , W.K. Lee , S. Zauscher , C.A.H. Prata , M.W. Grinstaff , Chem. Biol. 13, 695 (2006).

120.G.S. Nowakowski , M.S. Dooner , H.M. Valinski , A.M. Mihaliak , P.J. Quesenberry , P.S. Becker , Stem Cells 22, 1030 (2004).

121.D.A. Rothenfluh , H. Bermudez , C.P. O’Neil , J.A. Hubbell , Nat. Mater. 7, 248 (2008).

122.B.K. Kay , J. Winter , J. McCafferty , Phage Display of Peptides and Proteins (Academic Press, San Diego, 1996).

123.R.H. Hoess , Chem. Rev. 101, 3205 (2001).

124.G.P. Smith , V.A. Petrenko , Chem. Rev. 97, 391 (1997).

125.G. Smith , Science 228, 1315 (1985).

127.X. Khoo , P. Hamilton , G.A. O’Toole , B.D. Snyder , D.J. Kenan , M.W. Grinstaff , J. Am. Chem. Soc. 131, 10992 (2009).

128.X. Khoo , G.A. O’Toole , S.A. Nair , B.D. Snyder , D.J. Kenan , M.W. Grinstaff , Biomaterials 31, 9285 (2010).

129.S.R. Meyers , X. Khoo , X. Huang , E.B. Walsh , M.W. Grinstaff , D.J. Kenan , Biomaterials 30, 277 (2009).

130.T. Kacar , M.T. Zin , C. So , B. Wilson , H. Ma , N. Gul-Karaguler , A.K. Jen , M. Sarikaya , C. Tamerler , Biotechnol. Bioeng. 103, 696 (2009).

131.E.A. Scott , M.D. Nichols , L.H. Cordova , B.J. George , Y.S. Jun , D.L. Elbert , Biomaterials 29, 4481 (2008).

132.J. Kim , B.K. Wacker , D.L. Elbert , Biomacromolecules 8, 3682 (2007).

133.J.P. Bearinger , D.G. Castner , S.L. Golledge , A. Rezania , S. Hubchak , K.E. Healy , Langmuir 13, 5175 (1997).

134.N.P. Desai , S.F.A. Hossainy , J.A. Hubbell , Biomaterials 13, 417 (1992).

135.G.M. Harbers , K. Emoto , C. Greef , S.W. Metzger , H.N. Woodward , J.J. Mascali , D.W. Grainger , M.J. Lochhead , Chem. Mater. 19, 4405 (2007).

136.I.C. Saldarriaga Fernández , H.C.v.d. Mei , S. Metzger , D.W. Grainger , A.F. Engelsman , M.R. Nejadnik , H.J. Busscher , Acta Biomater. 6, 1119 (2009).

137.F. Boulmedais , B. Frisch , O. Etienne , P. Lavalle , C. Picart , J. Ogier , J.C. Voegel , P. Schaaf , C. Egles , Biomaterials 25, 2003 (2004).

138.L. Richert , P. Lavalle , E. Payan , X.Z. Shu , G.D. Prestwich , J.-F. Stoltz , P. Schaaf , J.-C. Voegel , C. Picart , Langmuir 20, 448 (2003).

139.O. Etienne , C. Picart , C. Taddei , Y. Haikel , J.L. Dimarcq , P. Schaaf , J.C. Voegel , J.A. Ogier , C. Egles , Antimicrob. Agents Chemother. 48, 3662 (2004).

140.Z. Li , D. Lee , X. Sheng , R.E. Cohen , M.F. Rubner , Langmuir 22, 9820 (2006).

141.S. Pavlukhina , Y. Lu , A. Patimetha , M. Libera , S. Sukhishvili , Biomacromolecules, 11 (12), 3448 (2010).

142.B.-S. Kim , S.W. Park , P.T. Hammond , ACS Nano 2, 386 (2008).

143.W. Yuan , J. Ji , J. Fu , J. Shen , J. Biomed. Mater. Res. B: Appl. Biomater. 85B, 556 (2008).

144.S.M. Olsen , L.T. Pedersen , M.H. Laursen , S. Kiil , K. Dam-Johansen , Biofouling: J. Bioadhesion Biofilm Res. 23, 369 (2007).

145.I. Francolini , G. Donelli , FEMS Immunol. Med. Microbiol. 59, 227 (2010).

147.S. Rotem , A. Mor , Biochimica et Biophysica Acta (BBA)— Biomembranes 1788 (8), 15821592 (2009).

148.H. Tang , T. Cao , X. Liang , A. Wang , S.O. Salley , J. McAllister II, K.Y.S. Ng , Journal of Biomedical Materials Research Part A 88A (2), 454463 (2009).

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

MRS Bulletin
  • ISSN: 0883-7694
  • EISSN: 1938-1425
  • URL: /core/journals/mrs-bulletin
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: