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Organic electrochemical transistors as impedance biosensors

  • Gregório C. Faria (a1), Duc T. Duong (a2), Alberto Salleo (a2), Christos A. Polyzoidis (a3), Stergios Logothetidis (a3), Jonathan Rivnay (a4), Roisin Owens (a4) and George G. Malliaras (a4)...
Abstract
Abstract

Interfacing organic electrochemical transistors (OECTs) with biological systems holds considerable promise for building-sensitive biosensors and diagnostic tools. We present a simple model that describes the performance of biosensors in which an OECT is integrated with a biological barrier layer. Using experimentally derived parameters we explore the limits of sensitivity and find that it is dependent on the resistance of the barrier layer. This work provides guidelines on how to optimize biosensors in which OECTs transduce changes in the impedance of biological layers, including lipid bilayer membranes and confluent cell layers.

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Address all correspondence to Alberto Salleo at asalleo@stanford.edu
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MRS Communications
  • ISSN: 2159-6859
  • EISSN: 2159-6867
  • URL: /core/journals/mrs-communications
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