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Chemoenzymatic Preparation of Sugar-Based Hydrogels

  • D. G. Rethwisch (a1), X. Chen (a1), B. D. Martin (a1) and J. S. Dordick (a1)
Abstract
ABSTRACT

We have prepared sugar-based hydrogels using a chemoenzymatic synthetic approach. Specifically, the regioselectivity of enzymes was used to prepare sugar acrylate monomers. These monomers were polymerized with a crosslinker in a standard free radical polymerization. The polymers consist of a polyacrylate backbone with sucrose, (α-methyl glucoside, or β-methyl galactoside pendant groups. These materials are highly water absorbent swelling to more than 100 times their initial weight when placed in water. The degree of swelling for poly(β-methyl galactoside 6-acrylate) hydrogel was relatively insensitive to pH (from pH 4.5-9) and ionic strength (0.15-3 M NaCl). Potential applications of these materials include waterabsorbents and drug delivery systems.

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1. T. Canal , N. A. Peppas , J. Biomed. Mater. Res. 23, 1183 (1989).

3. T. Otake , Bull. Chem. Soc. Jpn. 43, 3199 (1972).

4. J. M. Ballard , L. Hough , A. C. Richardson , Carbohydr. Res. 83, 138, (1980).

5. L. Hough , S. D. Phadnis , E. Tarelli , Carbohydr. Res. 44, 37 (1975).

6. J. D. Klein , D. Herzog , A. Hajibegli , Makromol. Chem. Rapid. Comm. 6, 675 (1985).

7. D. R. Patil , J. S. Dordick , D. G. Rethwisch , Macromolecules 24, 3462 (1991).

8. B. D. Martin , S. Ampofo , R. J. Linhardt , J. S. Dordick , Macromolecules 25, 7081 (1992)

9. D. R. Patil , D. G. Rethwisch , J. S. Dordick , Biotechnol. Bioeng. 37, 639 (1991).

10. J. S. Dordick , Enzyme Microb. Technol. 11, 194 (1989).

11. K. Dabulis , A.M. Klibanov , Biotechnol. Bioeng. 41, 566 (1993).

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MRS Online Proceedings Library (OPL)
  • ISSN: -
  • EISSN: 1946-4274
  • URL: /core/journals/mrs-online-proceedings-library-archive
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