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Comparative Study of the Antimicrobial Effect of Different Antibiotics Mixed with CuO, MgO and ZnO Nanoparticles in Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli cultures

Published online by Cambridge University Press:  14 October 2014

Raúl Alenó ,
Anthony López Collazo ,
Eulalia Medina ,
Lourdes Díaz Figueroa ,
José I. Ramírez  and
Edmy J. Ferrer Torres
Raúl Alenó
Affiliation:
Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Mercedita, P.R. 00715.
Anthony López Collazo
Affiliation:
Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Mercedita, P.R. 00715.
Eulalia Medina
Affiliation:
Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Mercedita, P.R. 00715.
Lourdes Díaz Figueroa
Affiliation:
Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Mercedita, P.R. 00715.
José I. Ramírez
Affiliation:
Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Mercedita, P.R. 00715.
Edmy J. Ferrer Torres*
Affiliation:
Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Mercedita, P.R. 00715.
*
*Research Director,ejferrer@ponce.inter.edu
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Abstract

Due to the rapid advance of the emergence of resistant microorganisms to different antibiotics, there is a need to create new antimicrobial agents. It is possible that Nanotechnology has a great impact in this area since the nanoparticles can improve the antimicrobial effect of the antibiotics. In this study we used three different metal oxides nanoparticles, the MgO, ZnO and CuO. These nanoparticles were selected because their interactions leading to cell death and their optical properties. The aim of this study is to develop new methods that are more effective against resistance bacteria, developing antibacterial agents using different nanoparticles against Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 10145), and Staphylococcus aureus (ATCC BAA-1026). This study was conducted to evaluate the antibacterial effects of a combination of nanoparticles together with different concentrations of three antibiotics, Gentamicin, Cephalexin and Co-Trimoxazole. The results showed that some nanoparticles are effective to inhibit growth in these microorganisms by increasing the effectiveness of the antibiotic. Therefore, the present study indicates that the combination of the nanoparticles with antibiotics may be applicable as a new antimicrobial agent.

Keywords

biomaterialnanoscalemixture
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1675: Symposium K/RR – Synthesis, Characterization and Applications of Functional Materials—Thin Films and Nanostructures , 2014 , pp. 59 - 64
Copyright
Copyright © Materials Research Society 2014 

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References

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