The dynamic light scattering (DLS) has been used to investigate the diffusion behavior and the size distribution of liposome. DLS experiments show two classes of particles with their hydrodynamic radii being 4-12 nm and 66-80 nm. The numbers of particles associated with the two peaks are estimated by means of the scattering properties of the particles, which show that the overwhelming majority is big ones.
Broadband dielectric spectroscopy (BDS) has been used to investigate the dynamical structure of liposome in aqueous solution of water, which makes it possible to precisely explain the molecular mechanism, structures and various properties as a function of temperature and frequency. We have observed four relaxation processes, where two low frequency processes are commonly observed in charged macromolecules in aqueous solution, third process appeared in the MHz region due to the motion of ions, which is also related to the molecular motion of the lipid, and the high frequency process appeared about 20 GHz is due to free water surrounding liposome. Gel-LC phase transition has been described very accurately from the temperature-dependent shape parameter, β, obtained from the Cole-Cole fitting. The β value in LC phase is smaller than that in gel phase.
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