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Incorporation of NSAID Drug Gel Derived from Cellulose and Polyacrylamide

Published online by Cambridge University Press:  01 February 2011

C. A. Morales ,
M. C. Castillo ,
Z. N. Díaz ,
S. J. González  and
V. O. Kharissova
C. A. Morales
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
M. C. Castillo
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
Z. N. Díaz
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
S. J. González
Affiliation:
División de Estudios de Posgrado e Investigación del Instituto Tecnológico de Ciudad Madero. Juventino Rosas y Jesús Urueta, S/N, Col. Los Mangos, C. P. 89440, Ciudad Madero, Tamaulipas, México. E-mail: acepeda71@yahoo.com
V. O. Kharissova
Affiliation:
Facultad de Ciencias Físico Matemáticas de la Universidad Autónoma de Nuevo León
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Abstract

In this paper, the incorporation and release of two types of drugs was carried out in microgels of hydroxypropylcellulose/polyacrylamide (HPC/PAAM) and hydroxyethylcellulose/polyacrylamide (HEC/PAAM). The two drugs were NSAIDs (nonsteroidal, anti-inflammatory drugs)—one antipyretic and one analgesic—acetylsalicylic acid (aspirin, ASP) and iuprofen (IBU), respectively. First, the microgels were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FTIR) in order to identify the presence of functional groups for each polymer. The incorporation of the drug was made by swelling the microgels in a drug solution and finally carrying out the release of the substances listed at 37° C. The results were obtained by UV-visible spectroscopy.

Keywords

polymeradsorptionbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1280: Nanomaterials for Biomedical Applications , 2010 , sim21-abs041
Copyright
Copyright © Materials Research Society 2010

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