- Cited by 2
Hu, Junqiang Gondarenko, Alexander A. Dang, Alex P. Bashour, Keenan T. O’Connor, Roddy S. Lee, Sunwoo Liapis, Anastasia Ghassemi, Saba Milone, Michael C. Sheetz, Michael P. Dustin, Michael L. Kam, Lance C. and Hone, James C. 2017. High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography. Nano Letters, Vol. 16, Issue. 4, p. 2198.
Eggermont, Loek J. Paulis, Leonie E. Tel, Jurjen and Figdor, Carl G. 2017. Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells. Trends in Biotechnology, Vol. 32, Issue. 9, p. 456.
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- Volume 1209
- 2009 , 1209-YY03-01
T lymphocytes are a key regulatory component of the adaptive immune system. Understanding how the micro- and nano-scale details of the extracellular environment influence T cell activation may have wide impact on the use of T cells for therapeutic purposes. In this article, we examine how the micro- and nano-scale presentation of ligands to cell surface receptors, including microscale organization and nanoscale mobility, influences the activation of T cells. We extend these studies to include the role of cell-generated forces, and the rigidity of the microenvironment, on T cell activation. These approaches enable delivery of defined signals to T cells, a step toward understanding the cell-cell communication in the immune system, and developing micro/nano- and material- engineered systems for tailoring immune responses for adoptive T cell therapies.
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