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Potential Bone Replacement Materials Prepared by TwoMethods

Published online by Cambridge University Press:  30 March 2012

Steve Lee ,
Michael Porter ,
Scott Wasko ,
Grace Lau ,
Po-Yu Chen ,
Ekaterina E. Novitskaya ,
Antoni P. Tomsia ,
Adah Almutairi ,
Marc A. Meyers  and
Joanna McKittrick
Steve Lee
Affiliation:
University of California, San Diego, Materials Science and Engineering Program, 9500 Gilman Dr., La Jolla, CA 92093 USA
Michael Porter
Affiliation:
University of California, San Diego, Materials Science and Engineering Program, 9500 Gilman Dr., La Jolla, CA 92093 USA
Scott Wasko
Affiliation:
University of California, San Diego, Skaggs School of Pharmacy, 9500 Gilman Dr., La Jolla, CA 92093 USA
Grace Lau
Affiliation:
Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA 94720 USA
Po-Yu Chen
Affiliation:
National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu 30013, Taiwan, R.O.C.
Ekaterina E. Novitskaya
Affiliation:
University of California, San Diego, Materials Science and Engineering Program, 9500 Gilman Dr., La Jolla, CA 92093 USA
Antoni P. Tomsia
Affiliation:
Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA 94720 USA
Adah Almutairi
Affiliation:
University of California, San Diego, Skaggs School of Pharmacy, 9500 Gilman Dr., La Jolla, CA 92093 USA
Marc A. Meyers
Affiliation:
University of California, San Diego, Materials Science and Engineering Program, 9500 Gilman Dr., La Jolla, CA 92093 USA University of California, San Diego, Dept. of Mechanical and Aerospace Engineering, 9500 Gilman Dr., La Jolla, CA 92093 USA
Joanna McKittrick
Affiliation:
University of California, San Diego, Materials Science and Engineering Program, 9500 Gilman Dr., La Jolla, CA 92093 USA University of California, San Diego, Dept. of Mechanical and Aerospace Engineering, 9500 Gilman Dr., La Jolla, CA 92093 USA
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Abstract

Natural and synthetic hydroxyapatite (HA) scaffolds for potentialload-bearing bone implants were fabricated by two methods. The naturalscaffolds were formed by heating bovine cancellous bone at 1325°C, whichremoved the organic and sintered the HA. The synthetic scaffolds wereprepared by freeze-casting HA powders, using different solid loadings (20–35vol.%) and cooling rates (1–10°C/min). Both types of scaffolds wereinfiltrated with polymethylmethacrylate (PMMA). The porosity, pore size, andcompressive mechanical properties of the natural and synthetic scaffoldswere investigated and compared to that of natural cortical and cancellousbone. Prior to infiltration, the sintered cancellous scaffolds exhibitedpore sizes of 100 – 300 μm, a strength of 0.4 – 9.7 MPa, and a Young’smodulus of 0.1 – 1.2 GPa. The freeze-casted scaffolds had pore sizes of 10 –50 μm, strengths of 0.7 – 95.1 MPa, and Young’s moduli of 0.1 –19.2 GPa.When infiltrated with PMMA, the cancellous bone- PMMA composite showed astrength of 55 MPa and a Young’s modulus of 4.5 GPa. Preliminary data forthe synthetic HA-PMMA composite showed a strength of 42 MPa and a modulus of0.8 GPa.

Keywords

bonecompositeceramic

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm06-02
Copyright
Copyright © Materials Research Society 2012

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