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Potential Bone Replacement Materials Prepared by Two Methods

  • Steve Lee (a1), Michael Porter (a1), Scott Wasko (a2), Grace Lau (a3), Po-Yu Chen (a4), Ekaterina E. Novitskaya (a1), Antoni P. Tomsia (a3), Adah Almutairi (a2), Marc A. Meyers (a1) (a5) and Joanna McKittrick (a1) (a5)...
Abstract
ABSTRACT

Natural and synthetic hydroxyapatite (HA) scaffolds for potential load-bearing bone implants were fabricated by two methods. The natural scaffolds were formed by heating bovine cancellous bone at 1325°C, which removed the organic and sintered the HA. The synthetic scaffolds were prepared by freeze-casting HA powders, using different solid loadings (20–35 vol.%) and cooling rates (1–10°C/min). Both types of scaffolds were infiltrated with polymethylmethacrylate (PMMA). The porosity, pore size, and compressive mechanical properties of the natural and synthetic scaffolds were investigated and compared to that of natural cortical and cancellous bone. Prior to infiltration, the sintered cancellous scaffolds exhibited pore sizes of 100 – 300 μm, a strength of 0.4 – 9.7 MPa, and a Young’s modulus of 0.1 – 1.2 GPa. The freeze-casted scaffolds had pore sizes of 10 – 50 μm, strengths of 0.7 – 95.1 MPa, and Young’s moduli of 0.1 –19.2 GPa. When infiltrated with PMMA, the cancellous bone- PMMA composite showed a strength of 55 MPa and a Young’s modulus of 4.5 GPa. Preliminary data for the synthetic HA-PMMA composite showed a strength of 42 MPa and a modulus of 0.8 GPa.

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1. S. Weiner , H.D. Wagner , Annu Rev Mater Sci 28, 271298 (1998).

2. T.M. Keaveny , E.F. Morgan , G.L. Niebur , O.C. Yeh , Annu Rev Biomed Eng 3, 307333 (2001).

3. E. Novitskaya , P.-Y. Chen , S. Lee , A. Castro-Ceseña , G. Hirata , V. Lubarda , J. McKittrick , Acta Biomater 7(8), 31703177 (2011).

4. P.-Y. Chen , J. McKittrick , J Mech Behav Biomed Mater 4(7), 961973 (2011).

5. Y. Kuboki , H. Takita , D. Kobayashi , E. Tsuruga , M. Inoue , M. Murata , ., J Biomed Mater Res 39(2), 190199 (1998).

6. Y.S. Chang , H.O. Gu , M. Kobayashi , M. Oka , J Arthroplasty 13(7), 816825 (1998).

8. S.F. Hulbert , F.A. Young , R.S. Mathews , J.J. Klawitter , C.D. Talbert , F.H. Stelling , J Biomed Mater Res 4(3), 433456 (1970).

9. B.S. Chang , C.K. Lee , K.S. Hong , H.J. Youn , H.S. Ryu , S.S. Chung , K.W. Park , Biomaterials 21(12), 12911298 (2000).

10. J.R. Woodard , A. J. Hilldore , S.K. Lan , C.J. Park , A.W. Morgan , J.C. Eurell , S.G. Clark , M.B. Wheeler , R.D. Jamison , A.J.W. Johnson , Biomater 28(1), 4554 (2007).

11. S.S. Liao , F.Z. Cui , Q.L. Feng , J Biomed Mater Res B 69B(2), 158165 (2004).

12. Z. Xiong , Y. Yan , S Wang , R. Zhang , C. Zhang , Scripta Mater 46(11), 771776 (2002).

13. C.Y. Lin , N. Kikuchi , S.J. Hollister , J Biomech 37(5), 623636 (2004).

14. J.M. Taboas , R.D. Maddox , P.H. Krebsbach , S.J. Hollister , Biomater 24(1), 181194 (2003).

15. H.R.R. Ramay , M. Zhang , Biomater 25(21), 51715180 (2004).

16. S. Deville , Adv Eng Mater 10(3), 155169 (2008).

17. M. Azami , F. Moztarzadeh , M. Tahriri , J Porous Mater 17, 313320 (2010).

18. S. Blindow , M. Pulkin , D. Koch , Adv Eng Mater 11(11), 875884 (2009).

19. S. Deville , E. Saiz , A.P. Tomsia , Biomaterials 27(32), 54805489 (2006).

20. Q. Fu , M.N. Mohamed , F. Dogan , B.S. Bal , Biomed Mater 3(2), (2008).

22. E.J. Lee , Y.H. Koh , B.H. Yoon , H.E. Kim , H.W. Kim , Mater Lett 61(11-12), 22702273 (2007).

23. T. Moritz , H.-J. Richter , J Am Ceram Soc, 89(8), 23942398 (2009).

25. T.Y. Yang , J.M. Lee , S.Y. Yoon , H.C. Park , J Mater Sci-Mater M 21(5), 14951502 (2010).

26. B.H. Yoon , C.S. Park , H.E. Kim , Y.H. Koh , Mater Lett 62(10-11), 17001703 (2008).

27. Y. Zhang , K. Zuo , Y.-P. Zeng , Ceramics International 35, 21512154 (2009).

28. K.H. Zuo , Y.P. Zeng , D.L. Jiang , Mater Sci Eng C-Mater Bio 30(2), 283287 (2010).

29. K.H. Zuo , Y.A. Zhang , Y.P. Zeng , D.L. Jiang , Ceram Int 37(1), 407410 (2011).

30. U.G.K. Wegst , M. Schecter , A.E. Donius , and P.M Hunger . Philoso T R Soc A 368, 20992121 (2010).

32. S. Deville , E. Saiz , A.P. Tomsia , Acta Mater 55(6), 19651974 (2007).

33. M.E. Launey , E. Munch , D.H. Alsem , H.B. Barth , E. Saiz , A.P. Tomsia , R.O. Ritchie , Acta Mater 57(10), 29192932 (2009).

34. E. Munch , M.E. Launey , D.H. Alsem , E. Saiz , A.P. Tomsia , R.O. Ritchie , Science 322(5907), 15161520 (2008).

35. F.J. Martinez-Vazquez , F.H. Perera , P. Mirand , A. Pajares , F. Guiberteau , Acta Biomater 6(11), 43614368 (2010).

36. X. Miao , W.-K. Lim , X. Huang , Y. Chen , Materials Letters 59, 4000-4005 (2005).M. Peroglio, L. Germillard, C. Gauthier, L. Chazeau, S. Verrier, M. Alini, J. Chevalier, Acta Biomater 6(11), 4369–4379(2010).

37. M. Peroglio , L. Germillard , C. Gauthier , L. Chazeau , S. Verrier , M. Alini , J. Chevalier , Acta Biomater 6(11), 43694379 (2010).

38. S. Sharifi , Y. Shafieyan , H. Mirzadeh , S. Bagheri-Khoulenjani , S.M. Rabiee , M. Imani , M. Atai , M.A. Shokrgozar , A. Hatampoor , J Biomed Mater Res A 98A(2), 257267 (2011).

39. G. Pezzotti , S.M.F. Asmus , L.P. Ferroni , S. Miki , J Mater Sci-Mater M 13(8), 783787 (2002).

40. L.L. Hench , J Am Ceram Soc 74(7), 14871510 (1991).

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