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Can satellite glial cells be therapeutic targets for pain control?

  • Luc Jasmin (a1) (a2), Jean-Philippe Vit (a3), Aditi Bhargava (a4) and Peter T. Ohara (a1)
  • DOI: http://dx.doi.org/10.1017/S1740925X10000098
  • Published online: 01 June 2010
Abstract

Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.

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Corresponding author
Correspondence should be addressed to: Luc Jasmin, Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue San Francisco, CA 94143-0452, USA phone: (415) 476-3761 fax: (415) 476-4845 email: ljasmin@gmail.com
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