J.B. Adams , L.J. Johansen , L.D. Powell , D. Quig and R.A. Rubin (2011) Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity. BMC Gastroenterology 11, 22.
G. Ahlsen , L. Rosengren , M. Belfrage , A. Palm , K. Haglid , A. Hamberger et al. (1993) Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders. Biological Psychiatry 33, 734–743.
Y.A. Al-Yafee , L.Y. Al-Ayadhi , S.H. Haq and A.K. El-Ansary (2011) Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia. BMC Neurology 11, 139.
K. Ashutosh (2000) Nitric oxide and asthma: a review. Current Opinion in Pulmonary Medicine 6, 21–25.
H.O. Atladóttir , P. Thorsen , D.E. Schendel , L. Østergaard , S. Lemcke and E.T. Parner (2010) Association of hospitalization for infection in childhood with diagnosis of autism spectrum disorders: a Danish cohort study. Archives of Pediatric and Adolescent Medicine 164, 470–477.
A. Bailey , P. Luthert , A. Dean , B. Harding , I. Janota , M. Montgomery et al. (1998) A clinicopathological study of autism. Brain 121, 889–905.
P. Barttfeld , B. Wicker , S. Cukier , S. Navarta , S. Lew and M. Sigman (2011) A big-world network in ASD: dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections. Neuropsychologia 49, 254–263.
M.K. Belmonte , G. Allen , A. Beckel-Mitchener , L.M. Boulanger , R.A. Carper and S.J. Webb (2004) Autism and abnormal development of brain connectivity. Journal of Neuroscience 24, 9228–9231.
I. Boger-Megiddo , D.W. Shaw , S.D. Friedman , B.F. Sparks , A.A. Artru , J.N. Giedd et al. (2006) Corpus callosum morphometrics in young children with autism spectrum disorder. Journal of Autism Developmental Disorders 36, 733–739.
J.P. Bolaños , S.J. Heales , J.M. Land and J.B. Clark (1995) Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. Journal of Neurochemistry 64, 1965–1972.
G.C. Brown (2001) Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochimica et Biophysica Acta 1504, 46–57.
L. Burroni , A. Orsi , L. Monti , Y. Hayek , R. Rocchi and A.G. Vattimo (2008) Regional cerebral blood flow in childhood autism: a SPET study with SPM evaluation. Nuclear Medicine Communications 29, 150–156.
S. Calatayud , D. Barrachina and J.V. Esplugues (2001) Nitric oxide: relation to integrity, injury, and healing of the gastric mucosa. Microscopy Research and Technique 53, 325–335.
S. Chatterjee , H. Noack , H. Possel and G. Wolf (2000) Induction of nitric oxide synthesis lowers intracellular glutathione in microglia of primary glial cultures. Glia 29, 98–101.
A. Chauhan , T. Audhya and V. Chauhan (2012) Brain region-specific glutathione redox imbalance in autism. Neurochemical Research (Epub ahead of print).
M.G. Chez , T. Dowling , P.B. Patel , P. Khanna and M. Kominsky (2007) Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatric Neurology 36, 361–365.
C.A. Colton and D.L. Gilbert (1987) Production of superoxide anions by a CNS macrophage, the microglia. FEBS Letters 223, 284–288.
E. Courchesne (1997) Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Current Opinion in Neurobiology 7, 269–278.
E. Courchesne and K. Pierce (2002) Autism. In V.S. Ramachandran (ed) Encyclopedia of the Human Brain. Academic, San Diego, pp. 321–342.
S.R. Damarla , T.A. Keller , R.K. Kana , V.L. Cherkassky , D.L. Williams , N.J. Minshew et al. (2010) Cortical underconnectivity coupled with preserved visuospatial cognition in autism: evidence from an fMRI study of an embedded figures task. Autism Research 3, 273–279.
S. Danielsson , I.C. Gillberg , E. Billstedt , C. Gillberg and I. Olsson (2005) Epilepsy in young adults with autism: a prospective population-based follow-up study of 120 individuals diagnosed in childhood. Epilepsia 46, 918–923.
I. Devenney , G. Norrman , T. Forslund , K. Fälth-Magnusson and T. Sundqvist (2010) Urinary nitric oxide excretion in infants with eczema. Pediatric Allergy and Immunology 21, e229–e234.
G. Dijkstra , H. van Goor , P.L. Jansen and H. Moshage (2004) Targeting nitric oxide in the gastrointestinal tract. Current Opinion in Investigational Drugs 5, 529–536.
A. Di Martino , C. Kelly , R. Grzadzinski , X.N. Zuo , M. Mennes , M.A. Mairena et al. (2011) Aberrant striatal functional connectivity in children with autism. Biological Psychiatry 69, 847–856.
S.J. Ebisch , V. Gallese , R.M. Willems , D. Mantini , W.B. Groen , G.L. Romani et al. (2011) Altered intrinsic functional connectivity of anterior and posterior insula regions in high-functioning participants with autism spectrum disorder. Human Brain Mapping 32, 1013–1028.
A.M. Enstrom , L. Lit , C.E. Onore , J.P. Gregg , R.L. Hansen , I.N. Pessah et al. (2005) Immunity, neuroglia and neuroinflammation in autism. International Review of Psychiatry 17, 485–495.
A.M. Enstrom , L. Lit , C.E. Onore , J.P. Gregg , R.L. Hansen , I.N. Pessah et al. (2009) Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behavior and Immunity 23, 124–133.
S.H. Fatemi , T.D. Folsom , T.J. Reutiman and S. Lee (2008) Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism. Synapse 62, 501–507.
J. Gehrmann , Y. Matsumoto and G.W. Kreutzberg (1995) Microglia: intrinsic immuneffector cell of the brain. Brain Research Reviews 20, 269–287.
D.A. Geier , J.K. Kern , C.R. Garver , J.B. Adams , T. Audhya and M.R. Geier (2009) A prospective study of transsulfuration biomarkers in autistic disorders. Neurochemical Research 34, 386–393.
C. Giulivi , Y.F. Zhang , A. Omanska-Klusek , C. Ross-Inta , S. Wong , I. Hertz-Picciotto et al. (2010) Mitochondrial dysfunction in autism. Journal of the American Medical Association 304, 2389–2396.
S.J. Heales , J.P. Bolaños and J.B. Clark (1996) Glutathione depletion is accompanied by increased neuronal nitric oxide synthase activity. Neurochemical Research 21, 35–39.
M.R. Herbert (2005) Large brains in autism: the challenge of pervasive abnormality. Neuroscientist 11, 417–440.
M.R. Herbert , D.A. Ziegler , C.K. Deutsch , L.M. O'Brien , D.N. Kennedy , P.A. Filipek et al. (2005) Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain 128, 213–226.
M.R. Herbert , D.A. Ziegler , N. Makris , P.A. Filipek , T.L. Kemper , J.J. Normandin et al. (2004) Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology 55, 530–540.
J. Hirrlinger , J.M. Gutterer , L. Kussmaul , B. Hamprecht and R. Dringen (2000) Microglial cells in culture express a prominent glutathione system for the defense against reactive oxygen species. Developmental Neuroscience 22, 384–392.
S.J. James , P. Cutler , S. Melnyk , S. Jernigan , L. Janak , D.W. Gaylor et al. (2004) Metabolic biomarkers of oxidative stress and impaired methylation capacity in children with autism. American Journal of Clinical Nutrition 80, 1611–1617.
S.J. James , S. Melnyk , S. Jernigan , M.A. Cleves , C.H. Halsted , D.H. Wong et al. (2006) Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 141B, 947–956.
S.J. James , S. Rose , S. Melnyk , S. Jernigan , S. Blossom , O. Pavliv et al. (2009) Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB Journal 23, 2374–2383.
M.A. Just , V.L. Cherkassky , T.A. Keller , R.K. Kana and N.J. Minshew (2007) Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cerebellar Cortex 17, 951–961.
T. Kagan-Kushnir , S.W. Roberts and O.C. Snead III (2005) Screening electroencephalograms in autism spectrum disorders: evidence-based guideline. Journal of Child Neurology 20, 197–206.
R.K. Kana , T.A. Keller and V.L. Cherkassky (2009) Atypical frontal-posterior synchronization of Theory of Mind regions in autism during mental state attribution. Society Neuroscience 4, 135–152.
O. Kann , R. Kovács , M. Njunting , C.J. Behrens , J. Otáhal , T.N. Lehmann et al. (2005) Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans. Brain 128, 2396–2407.
K.A. Kigerl , D.P. Ankeny , S.K. Garg , P. Wei , Z. Guan , W. Lai et al. (2011) System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo. Experimental Neurology 233, 333–341.
R. Kovács , A. Rabanus , J. Otáhal , A. Patzak , J. Kardos , K. Albus et al. (2009) Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices. Journal of Neuroscience 29, 8565–8577.
W.S. Kunz , A.P. Kudin , S. Vielhaber , I. Blümcke , W. Zuschratter , J. Schramm et al. (2000) Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy. Annals of Neurology 48, 766–773.
J.A. Laurence and S.H. Fatemi (2005) Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects. Cerebellum 4, 206–210.
R.H. Lee , E.A. Mills , N. Schwartz , M.R. Bell , K.E. Deeg , E.S. Ruthazer et al. (2010) Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system. Neural Development 5, 2.
X. Li , A. Chauhan , A.M. Sheikh , S. Patil , V. Chauhan , X.M. Li et al. (2009) Elevated immune response in the brain of autistic patients. Journal of Neuroimmunology 207, 111–116.
M.J. Maenner , C.L. Arneson , S.E. Levy , R.S. Kirby , J.S. Nicholas and M.S. Durkin (2011) Brief report: association between behavioral features and gastrointestinal problems among children with autism spectrum disorder. Journal of Autism and Developmental Disorders [Epub ahead of print]
N.J. Minshew and T.A. Keller (2010) The nature of brain dysfunction in autism: functional brain imaging studies. Current Opinion in Neurology 23, 124–130.
F. Monnet-Tschudi , A. Defaux , O. Braissant , L. Cagnon and M.G. Zurich (2011) Methods to assess neuroinflammation. Current Protocols in Toxicology, Chapter 12, Unit 12.19.
J.T. Morgan , G. Chana , C.A. Pardo , C. Achim , K. Semendeferi , J. Buckwalter et al. (2010) Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biological Psychiatry 68, 368–376.
D.W. Moss and T.E. Bates (2001) Activation of murine microglial cell lines by lipopolysaccharide and interferon-γ causes NO-mediated decreases in mitochondrial and cellular function. European Journal of Neuroscience 13, 529–538.
U.S. Naik , C. Gangadharan , K. Abbagani , B. Nagalla , N. Dasari and S.K. Manna (2011) A study of nuclear transcription factor-kappa B in childhood autism. PLoS One 6, e19488.
H. Nakanishi , Y. Hayashi and Z. Wu (2011) The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior. Neuron Glia Biology 28, 1–7.
G.L. Nicolson , R. Gan , N.L. Nicolson and J. Haier (2007) Evidence for Mycoplasma ssp., Chlamydia pneunomiae, and human herpes virus-6 coinfections in the blood of patients with autistic spectrum disorders. Journal of Neuroscience Research 85, 1143–1148.
S.J. Palmen , H. van Engeland , P.R. Hof and C. Schmitz (2004) Neuropathological findings in autism. Brain 127, 2572–2583.
C.A. Pardo , D.L. Vargas and A.W. Zimmerman (2005) Immunity, neuroglia and neuroinflammation in autism. International Review of Psychiatry 17, 485–495.
K. Radewicz , L.J. Garey , S.M. Gentleman and R. Reynolds (2000) Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. Journal of Neuropathology and Experimental Neurology 59, 137–150.
C.I. Reinders , M. Herulf , T. Ljung , J. Hollenberg , E. Weitzberg , J.O. Lundberg et al. (2005) Rectal mucosal nitric oxide in differentiation of inflammatory bowel disease and irritable bowel syndrome. Clinical Gastroenterology and Hepatology 3, 777–783.
G.L. Rintoul , V.J. Bennett , N.A. Papaconstandinou and I.J. Reynolds (2006) Nitric oxide inhibits mitochondrial movement in forebrain neurons associated with disruption of mitochondrial membrane potential. Journal of Neurochemistry 97, 800–806.
L.E. Rosengren , G. Ahlsén , M. Belfrage , C. Gillberg , K.G. Haglid and A. Hamberger (1992) A sensitive ELISA for glial fibrillary acidic protein: application in CSF of children. Journal of Neuroscience Methods 44, 113–119.
L.A. Schieve , V. Gonzalez , S.L. Boulet , S.N. Visser , C.E. Rice , K.V. Braun et al. (2011) Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Research in Developmental Disabilities 33, 467–476.
D.K. Shukla , B. Keehn , A.J. Lincoln and R.A. Müller (2010) White matter compromise of callosal and subcortical fiber tracts in children with autism spectrum disorder: a diffusion tensor imaging study. Journal of the American Academy of Child & Adolescent Psychiatry 49, 1269–1278.
K.C. Somera-Molina , S. Nair , L.J. Van Eldik , D.M. Watterson and M.S. Wainwright (2009) Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model. Brain Research 1282, 162–172.
K.C. Somera-Molina , B. Robin , C.A. Somera , C. Anderson , C. Stine , S. Koh et al. (2007) Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation. Epilepsia 48, 1785–1800.
V.C. Stewart and S.J. Heales (2003) Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration. Free Radical Biology and Medicine 34, 287–303.
W.J. Streit , R.E. Mrak and W.S. Griffin (2004) Microglia and neuroinflammation: a pathological perspective. Journal of Neuroinflammation 1, 14.
W.J. Streita (2006) Microglial senescence: does the brain's immune system have an expiration date? Trends in Neuroscience 29, 506–510.
A. Takabayashi , Y. Kawai , S. Iwata , M. Kanai , R. Denno , K. Kawada et al. (2000) Nitric oxide induces a decrease in the mitochondrial membrane potential of peripheral blood lymphocytes, especially in natural killer cells. Antioxidants and Redox Signaling 2, 673–680.
B. Tang , C.C. Piazza , D. Dolezal and M.T. Stein (2011) Severe feeding disorder and malnutrition in 2 children with autism. Journal of Developmental and Behavioral Pediatrics 32, 264–267.
N.A. Tetreault , A.Y. Hakeem , S. Jiang , B.A. Williams , E. Allman , B.J. Wold et al. (2012) Microglia in the cerebral cortex in autism. Journal of Autism and Developmental Disorders [Epub ahead of print].
N. Toda , K. Ayajiki and T. Okamura (2009) Cerebral blood flow regulation by nitric oxide in neurological disorders. Canadian Journal of Physiology and Pharmacology 87, 581–594.
M. Valko , D. Leibfritz , J. Moncol , M.T. Cronin , M. Mazur and J. Telser (2007) Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology 39, 44–84.
A. Vannacci , C. Ravaldi , L. Giannini , C.M. Rotella , E. Masini , C. Faravelli et al. (2006) Increased nitric oxide production in eating disorders. Neuroscience Letters 399, 230–233.
D.L. Vargas , C. Nascimbene , C. Krishnan , A.W. Zimmerman and C.A. Pardo (2005) Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology 57, 304.
A. Vojdani , E. Mumper , D. Granpeesheh , L. Mielke , D. Traver , K. Bock et al. (2008) Low natural killer cell cytotoxic activity in autism: the role of glutathione, IL-2 and IL-15. Journal of Neuroimmunology 205, 148–154.
L.W. Wang , D.J. Tancredi and D.W. Thomas (2011) The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. Journal of Developmental and Behavioral Pediatrics 32, 351–360.
S. Wass (2011) Distortions and disconnections: disrupted brain connectivity in autism. Brain Cognition 75, 18–28.
P.L. Wood (2003) Roles of CNS macrophages in neurodegeneration. In Neuroinflammation. Mechanisms and Management, 2nd edition. P.L.Wood (ed.). Humana Press, Totowa, NJ, pp. 3–27.
D.H. Yates (2001) Role of exhaled nitric oxide in asthma. Immunology and Cell Biology 79, 178–190.
A.M. Young , E. Campbell , S. Lynch , J. Suckling and S.J. Powis (2011) Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation. Frontiers in Psychiatry 2, 27.
H. Yuan , A.A. Gerencser , G. Liot , S.A. Lipton , M. Ellisman , G.A. Perkins et al. (2007) Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death and Differentiation 14, 462–471.
A.W. Zimmerman , H. Jyonouchi , A.M. Comi , S.L. Connors , S. Milstein , A. Varsou et al. (2005) Cerebrospinal fluid and serum markers of inflammation in autism. Pediatric Neurology 33, 195–201.