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The impact of garlic on lipid parameters: a systematic review and meta-analysis

  • Kurt M. Reinhart (a1) (a2), Ripple Talati (a1) (a2), C. Michael White (a1) (a2) and Craig I. Coleman (a1) (a2)


In order to determine the impact of garlic on total cholesterol (TC), TAG levels, as well as LDL and HDL, and establish if any variables have an impact on the magnitude of this effect, a meta-analysis was conducted. A systematic literature search of MEDLINE, CINAHL and the Cochrane Database from the earliest possible date through to November 2007 was conducted to identify randomised, placebo-controlled trials of garlic that reported effects on TC, TAG concentrations, LDL or HDL. The weighted mean difference of the change from baseline (with 95 % CI) was calculated as the difference between the means in the garlic groups and the control groups using a random-effects model. Subgroup and sensitivity analyses were performed to determine the effects on type, brand and duration of garlic therapy as well as baseline TC and TAG levels, the use of dietary modification, and study quality on the meta-analysis's conclusions. Twenty-nine trials were included in the analysis. Upon meta-analysis garlic was found to significantly reduce TC ( − 0·19; 95 % CI − 0·33, − 0·06 mmol/l) and TAG ( − 0·11; 95 % CI − 0·19, − 0·06 mmol/l) but exhibited no significant effect on LDL or HDL. There was a moderate degree of statistical heterogeneity for the TC and TAG analyses. Garlic reduces TC to a modest extent, an effect driven mostly by the modest reductions in TAG, without appreciable LDL lowering or HDL elevation. Higher baseline line TC levels and the use of dietary modification may alter the effect of garlic on these parameters. Future studies should be conducted evaluating the impact of adjunctive garlic therapy with fibrates or statins on TAG concentrations.

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Corresponding author

*Corresponding author: Dr Craig I. Coleman, fax +1 860 545 2277, email


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1Grundy, SM, Cleeman, JI, Merz, MB, et al. . (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110, 227239.
2Stevinson, C, Pittler, MH & Ernst, E (2000) Garlic for treating hypercholesterolemia. Ann Intern Med 133, 420429.
3Ackermann, RT, Mulrow, CD, Ramirez, G, et al. . (2001) Garlic shows promise for improving some cardiovascular risk factors. Arch Intern Med 161, 813824.
4Silagy, C & Neil, A (1994) Garlic as a lipid lowering agent – a meta-analysis. J R Coll Physicians Lond 28, 3945.
5Warshafsky, S, Kamer, RS & Sivak, SL (1993) Effect of garlic on total serum cholesterol a meta-analysis. Ann Intern Med 119, 599605.
6Kris-Etherton, PM & Dietschy, J (1997) Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies. Am J Clin Nutr 65, S1590S1596.
7Jadad, AR, Moore, A, Carroll, D, et al. . (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clin Trials 17, 112.
8Follmann, D, Elliott, P, Suh, I, et al. . (1992) Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 45, 769773.
9Adler, AJ & Holub, BJ (1997) Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 65, 445450.
10Auer, W, Eiber, A, Hertkorn, E, et al. . (1990) Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Pract Suppl 69, 36.
11Bordia, A (1981) Effect of garlic on blood lipids in patients with coronary heart disease. Am J Clin Nutr 34, 21002103.
12Budoff, MJ, Takasu, J, Flores, FR, et al. . (2004) Inhibiting progression of coronary calcification using aged garlic extract in patients receiving statin therapy: a preliminary study. Prev Med 39, 985991.
13Isaacsohn, JL, Moser, M, Stein, EA, et al. . (1998) Garlic powder and plasma lipids and lipoproteins. A multicenter, randomized, placebo-controlled trial. Arch Intern Med 158, 11891194.
14Jain, AK, Vargas, R, Gotzkowsky, S, et al. . (1993) Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med 94, 632635.
15Kannar, D, Wattanapenpaiboon, N, Savige, GS, et al. . (2001) Hypocholersterolemic effect of an enteric-coated garlic supplement. J Am Coll Nutr 20, 225231.
16Kiesewetter, H, Jung, F, Jung, EM, et al. . (1993) Effects of garlic coated tablets in peripheral arterial occlusive disease. Clin Investig 71, 383386.
17Macan, H, Uykimpang, R, Alconcel, M, et al. . (2006) Aged garlic extract may be safe for patients on warfarin therapy. J Nutr 136, 793S795S.
18Mader, FH (1990) Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung 40, 11111116.
19McCrindle, BW, Helden, E & Conner, WT (1998) Garlic extract therapy in children with hypercholesterolemia. Arch Pediatr Adolesc Med 152, 10891094.
20Neil, HAW, Silagy, CA, Lancaster, T, et al. . (1996) Garlic powder in the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis. J R Coll Physicians Lond 30, 329334.
21Peleg, A, Hershcovici, T, Lipa, R, et al. . (2003) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia. Isr Med Assoc J 5, 637640.
22Rahmani, M, Tabari, AK, Niaki, MRK, et al. . (1999) Effect of dried garlic supplementation on blood lipids in mild and moderate hypercholesterolemic patients. Arch Iran Med 2, 1923.
23Rotzsch, W, Richter, V, Rassoul, F, et al. . (1992) Postprandial lipeaemia under treatment with Allium sativum. Controlled double-blind study in healthy volunteers with reduced HDL2-cholesterol levels. Arzneimittelforschung 42, 12231227.
24Santos, OSDA & Grünwald, J (1993) Effect of garlic powder tablets on blood lipids and blood pressure – a six month placebo controlled, double blind study. Br J Clin Res 4, 3744.
25Saradeth, T, Seidl, S, Resch, KL, et al. . (1994) Does garlic alter the lipid pattern in normal volunteers? Phytomedicine 1, 183185.
26Satitvipawee, T, Rawdaree, P, Indrabhakti, S, et al. . (2003) No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects. J Med Assoc Thai 86, 750757.
27Superko, HR & Krauss, RM (2000) Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a). J Am Coll Cardiol 35, 321326.
28Vorberg, G & Schneider, B (1990) Therapy with garlic; results of a placebo-controlled, double blind study. Br J Clin Pract Suppl 69, 711.
29Zhang, XH, Lowe, D, Giles, P, et al. . (2000) A randomized trial of the effects of garlic oil upon coronary heart disease risk factors in trained male runners. Blood Coagul Fibrinolysis 11, 6774.
30Zhang, XH, Lowe, D, Giles, P, et al. . (2001) Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. J Nutr 131, 14711478.
31Phelps, S & Harris, WS (1993) Garlic supplementation and lipoprotein oxidation susceptibility. Lipids 28, 475477.
32Berthold, HK, Sudhop, T & Bergmann, KV (1998) Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. A randomized controlled trial. JAMA 279, 19001902.
33Simons, LA, Balasubramaniam, S, Konigsmark, MV, et al. . (1994) On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis 113, 219225.
34Steiner, M, Khan, AH, Holbert, D, et al. . (1996) A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 64, 866870.
35Tanamai, J, Veeramanomai, S & Indrakosas, N (2004) The efficacy of cholesterol-lowering action and side effects of garlic enteric coated tablets in man. J Med Assoc Thai 87, 11561161.
36Williams, MJ, Sutherland, WH, McCormick, MP, et al. . (2005) Aged garlic extract improves endothelial function in men with coronary artery disease. Phytother Res 19, 314319.
37Plengvidhya, C, Sitprija, S, Chinayon, S, et al. . (1988) Effects of spray dried garlic preparation on primary hyperlipoproteinemia. J Med Assoc Thai 71, 248252.
38Bordia, A, Verma, SK & Srivastava, KC (1998) Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 58, 257263.
39Lau, BHS, Lam, F & Wang-Cheng, R (1987) Effect of an odor-modified garlic preparation on blood lipids. Nutr Res 7, 139149.
40Brosche, T, Platt, D & Dorner, H (1990) The effect of a garlic preparation on the composition of plasma lipoproteins and erythrocyte membranes in geriatric subjects. Br J Clin Pract Suppl 69, 1219.
41Zimmermann, W & Zimmerman, B (1990) Reduction in elevated blood lipids in hospitalized patients by a standardised garlic preparation. Br J Clin Pract Suppl 69, 2023.
42Santos, OSDA & Johns, RA (1995) Effects of garlic powder and garlic oil preparations on blood lipids, blood pressure and well being. Br J Clin Res 6, 91100.
43Ziaei, S, Hantoshzadeh, S, Rezasoltani, R, et al. . (2001) The effect of garlic tablet on plasma lipids and platelet aggregation in nulliparous pregnants at high risk of preeclampsia. Eur J Obstet Gynecol Reprod Biol 99, 201206.
44Schmidt, U (1991) The lipid-lowering effects of garlic powder tablets. A comparative study between a garlic powder preparation and bezafibrate (article in German). Med Welt 42, 7 Suppl. A, 67.
45Chernyad'eva, IF, Shil'nikova, SV, Rogoza, AN, et al. . (2003) Dynamics of interrelationships between the content of lipoprotein particles, fibrinogen, and leukocyte count in the plasma from patients with coronary heart disease treated with Kwai®. Bull Exp Biol Med 135, 436439.
46Kojuri, J, Vosoughi, AR & Akrami, M (2007) Effects of Anethum graveolens and garlic on lipid profile in hyperlipidemic patients. Lipids Health Dis 6, 5.
47Gardner, CD, Lawson, LD, Block, E, et al. . (2007) Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia. Arch Intern Med 167, 146153.
48Ashraf, R, Aamir, R, Shaikh, AR, et al. . (2005) Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J Ayub Med Coll Abbottabad 17, 6064.
49Gardner, CD, Chatterjee, LM & Carlson, JJ (2001) The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults. Atherosclerosis 154, 213220.
50Lash, JP, Cardoso, LR, Mesler, PM, et al. . (1998) The effect of garlic on hypercholesrolemia in renal transplant patients. Transplant Proc 30, 189191.
51Van Doorn, MBA, Santo, SME, Meijer, P, et al. . (2006) Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects. Am J Clin Nutr 84, 13241329.
52Zhang, L, Gail, MH, Wang, Y, et al. . (2006) A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-weeks antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins. Am J Clin Nutr 84, 912919.
53Turner, B, Mølgaard, C & Marckmann, P (2004) Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomized, double-blind, placebo-controlled trial. Br J Nutr 92, 701706.
54Kiesewetter, H, Jung, F, Pindur, G, et al. . (1991) Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharmacol Ther Toxicol 29, 151155.
55Luley, C, Lehmann-Leo, W, Möller, B, et al. . (1986) Lack of efficacy of dried garlic in patients with hyperlipoproteinemia. Arzneimittelforschung 36, 766768.
56Jung, F & Kiesewetter, H (1991) Influence of a lipid load on plasma lipids and capillary skin perfusion under garlic (article in German). Med Welt 42, 1619.
57Byrne, DJ, Neil, HAW, Vallance, DT, et al. . (1999) A pilot study of garlic consumption shows no significant effect on markers of oxidation or sub-fraction composition of low-density lipoprotein including lipoprotein(a) after allowance for non-compliance and the placebo effect. Clin Chim Acta 285, 2133.
58Rosenson, RS (2003) Rosuvastatin: a new inhibitor of HMG-coA reductase for the treatment of dyslipidemia. Expert Rev Cardiovasc Ther 1, 495505.
59White, CM (1996) Treatment of hypercholesterolemia. In U. S. Pharmacist, July 1996, pp. 7690. Lyndhwst, NJ: Jobson Medical Information LLC.
60Holzgartner, H, Schmidt, U & Kuhm, U (1992) Comparison of the efficacy and tolerance of a garlic preparation v. bezafibrate. Drug Res 42, 14731477.
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