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Misconceptions about fructose-containing sugars and their role in the obesity epidemic

  • Vincent J. van Buul (a1), Luc Tappy (a2) and Fred J. P. H. Brouns (a1)


A causal role of fructose intake in the aetiology of the global obesity epidemic has been proposed in recent years. This proposition, however, rests on controversial interpretations of two distinct lines of research. On one hand, in mechanistic intervention studies, detrimental metabolic effects have been observed after excessive isolated fructose intakes in animals and human subjects. On the other hand, food disappearance data indicate that fructose consumption from added sugars has increased over the past decades and paralleled the increase in obesity. Both lines of research are presently insufficient to demonstrate a causal role of fructose in metabolic diseases, however. Most mechanistic intervention studies were performed on subjects fed large amounts of pure fructose, while fructose is ordinarily ingested together with glucose. The use of food disappearance data does not accurately reflect food consumption, and hence cannot be used as evidence of a causal link between fructose intake and obesity. Based on a thorough review of the literature, we demonstrate that fructose, as commonly consumed in mixed carbohydrate sources, does not exert specific metabolic effects that can account for an increase in body weight. Consequently, public health recommendations and policies aiming at reducing fructose consumption only, without additional diet and lifestyle targets, would be disputable and impractical. Although the available evidence indicates that the consumption of sugar-sweetened beverages is associated with body-weight gain, and it may be that fructose is among the main constituents of these beverages, energy overconsumption is much more important to consider in terms of the obesity epidemic.

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* Corresponding author: Professor Fred Brouns, email


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1 Bleich, SN, Wang, YC, Wang, Y, et al. (2009) Increasing consumption of sugar-sweetened beverages among US adults: 1988-1994 to 1999-2004. Am J Clin Nutr 89, 372381.
2 Duffey, KJ & Popkin, BM (2012) Shifts in patterns and consumption of beverages between 1965 and 2002. Obesity 15, 27392747.
3 Nielsen, SJ & Popkin, BM (2004) Changes in beverage intake between 1977 and 2001. Am J Prev Med 27, 205210.
4 Popkin, BM & Nielsen, SJ (2012) The sweetening of the world's diet. Obes Res 11, 13251332.
5 Nielsen, SJ, Siega-Riz, AM & Popkin, BM (2012) Trends in energy intake in US between 1977 and 1996: similar shifts seen across age groups. Obes Res 10, 370378.
6 Storey, ML, Forshee, RA & Anderson, PA (2006) Beverage consumption in the US population. J Am Diet Assoc 106, 19922000.
7 Wang, YC, Gortmaker, SL, Sobol, AM, et al. (2006) Estimating the energy gap among US children: a counterfactual approach. Pediatrics 118, e1721e1733.
8 Euromonitor International (2011) Soft drink consumption – global. Euromonitor Passport GMID database.
9 Young, LR & Nestle, M (2003) Expanding portion sizes in the US marketplace: implications for nutrition counseling. J Am Diet Assoc 103, 231234.
10 Wang, YC, Bleich, SN & Gortmaker, SL (2008) Increasing caloric contribution from sugar-sweetened beverages and 100% fruit juices among US children and adolescents, 1988-2004. Pediatrics 121, e1604e1614.
11 Welsh, JA, Sharma, AJ, Grellinger, L, et al. (2011) Consumption of added sugars is decreasing in the United States. Am J Clin Nutr 94, 726734.
12 Euromonitor International (2013) Bottled water consumption – global. Euromonitor Passport GMID database.
13 Ogden, CL, Carroll, MD, Kit, BK, et al. (2012) Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 307, 483490.
14 Euromonitor International (2013) Soft drink consumption per category – Western Europe. Euromonitor Passport GMID database.
15 Euromonitor International (2013) Soft drink consumption per category – North America: USA. Euromonitor Passport GMID database.
16 Malik, VS, Schulze, MB & Hu, FB (2006) Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 84, 274288.
17 Hu, FB & Malik, VS (2010) Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence. Physiol Behav 100, 4754.
18 Ambrosini, GL, Oddy, WH, Huang, RC, et al. (2013) Prospective associations between sugar-sweetened beverage intakes and cardiometabolic risk factors in adolescents. Am J Clin Nutr 98, 327334.
19 Agostoni, C, Bresson, JL, Fairweather-Tait, S, et al. (2010) Scientific opinion on dietary reference values for carbohydrates and dietary fibre. EFSA J 8, 14621539.
20 Kaiser, K, Shikany, J, Keating, K, et al. (2013) Will reducing sugar-sweetened beverage consumption reduce obesity? Evidence supporting conjecture is strong, but evidence when testing effect is weak. Obes Rev 14, 620633.
21 Ervin, R & Ogden, C (2013) Consumption of added sugars among U.S. adults, 2005-2010. NCHS Data Brief 122, 18.
22 Lustig, RH, Schmidt, LA & Brindis, CD (2012) Public health: the toxic truth about sugar. Nature 482, 2729.
23 Lustig, RH (2010) Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc 110, 13071321.
24 Johnson, RJ, Lanaspa, MA & Sanchez-lozada, LG (2012) Effects of excessive fructose intake on health. Ann Intern Med 156, 905906.
25 Melanson, KJ, Angelopoulos, TJ, Nguyen, V, et al. (2008) High-fructose corn syrup, energy intake, and appetite regulation. Am J Clin Nutr 88, 1738S1744S.
26 Perez-Pozo, S, Schold, J, Nakagawa, T, et al. (2009) Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes 34, 454461.
27 Rizkalla, SW (2010) Health implications of fructose consumption: a review of recent data. Nutr Metab (Lond) 7, 82.
28 Bray, GA (2008) Fructose: should we worry? Int J Obes 32, S127S131.
29 Bray, GA (2008) Fructose - how worried should we be? Medscape J Med 10, 159.
30 Bray, GA (2012) Fructose and risk of cardiometabolic disease. Curr Atheroscler Rep 14, 570578.
31 Bray, GA (2013) Potential health risks from beverages containing fructose found in sugar or high-fructose corn syrup. Diabetes Care 36, 1112.
32 Bray, GA, Nielsen, SJ & Popkin, BM (2004) Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79, 537543.
33 Brown, C, Dulloo, A & Montani, J (2008) Sugary drinks in the pathogenesis of obesity and cardiovascular diseases. Int J Obes 32, S28S34.
34 Brown, IJ, Stamler, J, Van Horn, L, et al. (2011) Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: International Study of Macro/Micronutrients and Blood Pressure. Hypertension 57, 695701.
35 Malik, VS & Hu, FB (2012) Sweeteners and risk of obesity and type 2 diabetes: the role of sugar-sweetened beverages. Curr Diab Rep 12, 195203.
36 Popkin, BM (2012) Sugary beverages represent a threat to global health. Trends Endocrinol Metab 23, 591593.
37 Klurfeld, DM (2013) What do government agencies consider in the debate over added sugars? Adv Nutr 4, 257261.
38 Elbel, B, Cantor, J & Mijanovich, T (2012) Potential effect of the New York City policy regarding sugared beverages. N Engl J Med 367, 680681.
39 Caprio, S (2012) Calories from soft drinks - do they matter? N Engl J Med 367, 14621463.
40 Anonymous (2012) Regulation of sugar-sweetened beverages. N Engl J Med 367, 14641466.
41 Chaufan, C, Hong, GH & Fox, P (2009) Taxing “sin foods” - obesity prevention and public health policy. N Engl J Med 361, e113.
42 Pomeranz, JL & Brownell, KD (2012) Portion sizes and beyond - government's legal authority to regulate food-industry practices. N Engl J Med 367, 13831385.
43 Cohen, DA & Babey, SH (2012) Candy at the cash register - a risk factor for obesity and chronic disease. N Engl J Med 367, 13811383.
44 Just, DR & Payne, CR (2009) Obesity: can behavioral economics help? Ann Behav Med 38, 4755.
45 Wansink, B, Hanks, A & Just, D (2012) et al. From Coke to Coors: a field study of a sugar-sweetened beverage tax and its unintended consequences. Social Science Research Network [serial on the Internet]. = 2079840.
46 White, JS (2008) Straight talk about high-fructose corn syrup: what it is and what it ain't. Am J Clin Nutr 88, 1716S1721S.
47 , K-A & Tappy, L (2006) Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 9, 469475.
48 Bogdanov, S, Jurendic, T, Sieber, R, et al. (2008) Honey for nutrition and health: a review. J Am Coll Nutr 27, 677689.
49 Casazza, K, Fontaine, KR, Astrup, A, et al. (2013) Myths, presumptions, and facts about obesity. N Engl J Med 368, 446454.
50 Agostoni, C, Bresson, JL, Fairweather-Tait, S, et al. (2011) Scientific opinion on the substantiation of health claims related to fructose and reduction of post-prandial glycaemic responses (ID 558) pursuant to Article 13(1) of Regulation (EC) no 1924/2006. EFSA J 9, 22232238.
51 Bantle, JP, Laine, DC, Castle, GW, et al. (1983) Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. N Engl J Med 309, 712.
52 Crapo, PA, Kolterman, OG & Olefsky, JM (1980) Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care 3, 575581.
53 Stanhope, KL & Havel, PJ (2008) Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup. Am J Clin Nutr 88, 1733S1737S.
54 Stanhope, KL, Schwarz, JM, Keim, NL, et al. (2009) Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119, 13221324.
55 Stanhope, KL & Havel, PJ (2010) Fructose consumption: recent results and their potential implications. Ann N Y Acad Sci 1190, 1524.
56 Tappy, L & , K-A (2010) Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90, 2346.
57 Vasankari, TJ & Vasankari, TM (2006) Effect of dietary fructose on lipid metabolism, body weight and glucose tolerance in humans. Food Nutr Res 50, 5563.
58 Grundy, SM (1998) Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 67, 563S572S.
59 Martinez-Gonzalez, M, Alfredo Martinez, J, Hu, F, et al. (1999) Physical inactivity, sedentary lifestyle and obesity in the European Union. Int J Obes 23, 11921201.
60 Torres, SJ & Nowson, CA (2007) Relationship between stress, eating behavior, and obesity. Nutrition 23, 887894.
61 Sobal, J & Stunkard, AJ (1989) Socioeconomic status and obesity: a review of the literature. Psychol Bull 105, 260275.
62 de Ruyter, JC, Olthof, MR, Seidell, JC, et al. (2012) A trial of sugar-free or sugar-sweetened beverages and body weight in children. N Engl J Med 367, 13971406.
63 Ebbeling, CB, Feldman, HA, Chomitz, VR, et al. (2012) A randomized trial of sugar-sweetened beverages and adolescent body weight. N Engl J Med 367, 14071416.
64 Golay, A & Bobbioni, E (1997) The role of dietary fat in obesity. Int J Obes Relat Metab Disord 21, S2.
65 Allais, O, Bertail, P & Nichèle, V (2010) The effects of a fat tax on French households' purchases: a nutritional approach. Am J Agric Econ 92, 228245.
66 Gaby, AR (2005) Adverse effects of dietary fructose. Altern Med Rev 10, 294.
67 Parker, K, Salas, M & Nwosu, VC (2010) High fructose corn syrup: production, uses and public health concerns. Biotechnol Mol Biol Rev 5, 7178.
68 Havel, PJ (2008) Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 63, 133157.
69 Hallfrisch, J (1990) Metabolic effects of dietary fructose. FASEB J 4, 26522660.
70 Vos, MB, Kimmons, JE, Gillespie, C, et al. (2008) Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J Med 10, 160.
71 Mayes, PA (1993) Intermediary metabolism of fructose. Am J Clin Nutr 58, 754S765S.
72 Shimomura, I, Matsuda, M, Hammer, RE, et al. (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6, 7786.
73 Rizkalla, SW, Luo, J, Guilhem, I, et al. (1992) Comparative effects of 6 week fructose, dextrose and starch feeding on fat-cell lipolysis in normal rats: effects of isoproterenol, theophylline and insulin. Mol Cell Biochem 109, 127132.
74 Havel, PJ (1997) Glucose but not fructose infusion increases circulating leptin in proportion to adipose stores in rhesus monkeys. Exp Clin Endocrinol Diabetes 105, 3738.
75 Puigserver, P & Spiegelman, BM (2003) Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr Rev 24, 7890.
76 McDevitt, RM, Bott, SJ, Harding, M, et al. (2001) De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am J Clin Nutr 74, 737746.
77 Teff, KL, Grudziak, J, Townsend, RR, et al. (2009) Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab 94, 15621569.
78 Vuorinen-Markkola, H & Yki-Järvinen, H (1994) Hyperuricemia and insulin resistance. J Clin Endocrinol Metab 78, 2529.
79 Nakagawa, T, Hu, H, Zharikov, S, et al. (2006) A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol 290, F625F631.
80 Lanaspa, MA, Sanchez-Lozada, LG, Cicerchi, C, et al. (2012) Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLOS ONE 7, e47948.
81 Abdelmalek, MF, Suzuki, A, Guy, C, et al. (2010) Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51, 19611971.
82 Togashi, N, Ura, N, Higashiura, K, et al. (2000) The contribution of skeletal muscle tumor necrosis factor-α to insulin resistance and hypertension in fructose-fed rats. J Hypertens 18, 16051610.
83 Bezerra, RM, Ueno, M, Silva, MS, et al. (2000) A high fructose diet affects the early steps of insulin action in muscle and liver of rats. J Nutr 130, 15311535.
84 Babsky, NE, Toribio, JL & Lozano, JE (1986) Influence of storage on the composition of clarified apple juice concentrate. J Food Sci 51, 564567.
85 Ventura, EE, Davis, JN & Goran, MI (2010) Sugar content of popular sweetened beverages based on objective laboratory analysis: focus on fructose content. Obesity 19, 868874.
86 Fung, TT, Malik, V, Rexrode, KM, et al. (2009) Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr 89, 10371042.
87 Chen, L, Caballero, B, Mitchell, DC, et al. (2010) Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure a prospective study among United States adults. Circulation 121, 23982406.
88 Dhingra, R, Sullivan, L, Jacques, PF, et al. (2007) Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation 116, 480488.
89 Meyer, KA, Kushi, LH, Jacobs, DR, et al. (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 71, 921930.
90 Janket, S-J, Manson, JE, Sesso, H, et al. (2003) A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care 26, 10081015.
91 Abdelmalek, MF, Lazo, M, Horska, A, et al. (2012) Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology 56, 952960.
92 Paynter, NP, Yeh, H-C, Voutilainen, S, et al. (2006) Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus. Am J Epidemiol 164, 10751084.
93 Forshee, RA, Anderson, PA & Storey, ML (2008) Sugar-sweetened beverages and body mass index in children and adolescents: a meta-analysis. Am J Clin Nutr 87, 16621671.
94 Duffey, KJ & Popkin, BM (2008) High-fructose corn syrup: is this what's for dinner? Am J Clin Nutr 88, 1722S1732S.
95 de Koning, L, Malik, VS, Rimm, EB, et al. (2011) Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. Am J Clin Nutr 93, 13211327.
96 Goran, MI, Ulijaszek, SJ & Ventura, EE (2012) High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 8, 5564.
97 Kmietowicz, Z (2012) Countries that use large amounts of high fructose corn syrup have higher rates of type 2 diabetes. BMJ 345, e7994.
98 European Commission (2012) Production data of HFCS (isoglucose) in the EU [database on the Internet]. (accessed 27 March 2013).
99 Gustavsson, J, Cederberg, C, Sonesson, U, et al (2011) Global Food Losses and Food Waste. Rome: UNFAO.
100 Basu, S, Yoffe, P, Hills, N, et al. (2013) The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLOS ONE 8, e57873.
101 Strom, S (2012) U.S. cuts estimate of sugar intake. New York Times, 27 October 2012, section B1. = 0 (accessed accessed February 2014).
102 Muth, MK (2011) Consumer-Level Food Loss Estimates and Their Use in the ERS Loss-Adjusted Food Availability Data. Darby, PA: Diane Publishing.
103 , K-A, Ith, M, Kreis, R, et al. (2009) Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 89, 17601765.
104 Faeh, D, Minehira, K, Schwarz, J-M, et al. (2005) Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 54, 19071913.
105 Hamburg, NM, McMackin, CJ, Huang, AL, et al. (2007) Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol 27, 26502656.
106 Egli, L, Lecoultre, V, Theytaz, F, et al. (2013) Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Diabetes 62, 22592265.
107 Koutsari, C, Karpe, F, Humphreys, SM, et al. (2001) Exercise prevents the accumulation of triglyceride-rich lipoproteins and their remnants seen when changing to a high-carbohydrate diet. Arterioscler Thromb Vasc Biol 21, 15201525.
108 Elliott, SS, Keim, NL, Stern, JS, et al. (2002) Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76, 911922.
109 Bantle, JP, Raatz, SK, Thomas, W, et al. (2000) Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 72, 11281134.
110 Couchepin, C, , K-A, Bortolotti, M, et al. (2008) Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects. Diabetes Care 31, 12541256.
111 Tran, C, Jacot-Descombes, D, Lecoultre, V, et al. (2010) Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load. Br J Nutr 104, 11391147.
112 Daly, M (2003) Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutr 78, 865S872S.
113 Lakhan, SE (2013) Kirchgessner A The emerging role of dietary fructose in obesity and cognitive decline. Nutr J 12, 114.
114 Klurfeld, D, Foreyt, J, Angelopoulos, T, et al. (2013) Lack of evidence for high fructose corn syrup as the cause of the obesity epidemic. Int J Obes 37, 771773.
115 DiMeglio, DP & Mattes, RD (2000) Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes 24, 794800.
116 Melanson, KJ, Zukley, L, Lowndes, J, et al. (2007) Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition 23, 103112.
117 Mærsk, M, Belza, A, Holst, JJ, et al. (2012) Satiety scores and satiety hormone response after sucrose-sweetened soft drink compared with isocaloric semi-skimmed milk and with non-caloric soft drink: a controlled trial. Eur J Clin Nutr 66, 523529.
118 Soenen, S & Westerterp-Plantenga, MS (2007) No differences in satiety or energy intake after high-fructose corn syrup, sucrose, or milk preloads. Am J Clin Nutr 86, 15861594.
119 Reid, M, Hammersley, R, Duffy, M, et al. (2014) Effects on obese women of the sugar sucrose added to the diet over 28 d: a quasi-randomised, single-blind, controlled trial. Br J Nutr 111, 563570.
120 Allison, DB (2014) Liquid calories, energy compensation and weight: what we know and what we still need to learn. Br J Nutr 111, 384386.
121 Welsh, JA, Sharma, A, Cunningham, SA, et al. (2011) Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents: clinical perspective. Circulation 123, 249257.
122 Rodin, J (1990) Comparative effects of fructose, aspartame, glucose, and water preloads on calorie and macronutrient intake. Am J Clin Nutr 51, 428435.
123 Rodin, J, Reed, D & Jamner, L (1988) Metabolic effects of fructose and glucose: implications for food intake. Am J Clin Nutr 47, 683689.
124 Te Morenga, L, Mallard, S & Mann, J (2013) Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ 346, e7492.
125 Moran, TH (2009) Fructose and satiety. J Nutr 139, 1253S1256S.
126 Sievenpiper, JL, de Souza, RJ & Jenkins, DJ (2012) Sugar: fruit fructose is still healthy. Nature 482, 470.
127 Slavin, J (2012) Beverages and body weight: challenges in the evidence-based review process of the Carbohydrate Subcommittee from the 2010 Dietary Guidelines Advisory Committee. Nutr Rev 70, S111S120.
128 Page, KA, Chan, O, Arora, J, et al. (2013) Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways fructose consumption and weight gain. JAMA 309, 6370.
129 Chong, MF, Fielding, BA & Frayn, KN (2007) Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 85, 15111520.
130 Hellerstein, MK, Schwarz, J-M & Neese, RA (1996) Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr 16, 523557.
131 Acheson, K, Schutz, Y, Bessard, T, et al. (1988) Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. Am J Clin Nutr 48, 240247.
132 Sun, SZ & Empie, MW (2012) Fructose metabolism in humans - what isotopic tracer studies tell us. Nutr Metab 9, 89.
133 Johnson, RJ, Perez-Pozo, SE, Sautin, YY, et al. (2009) Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev 30, 96116.
134 Feig, DI, Kang, D-H & Johnson, RJ (2008) Uric acid and cardiovascular risk. N Engl J Med 359, 18111821.
135 Sánchez-Lozada, LG, Mu, W, Roncal, C, et al. (2010) Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr 49, 19.
136 Oberhaensli, R, Taylor, D, Rajagopalan, B, et al. (1987) Study of hereditary fructose intolerance by use of 31P magnetic resonance spectroscopy. Lancet 330, 931934.
137 Lecoultre, V, Egli, L, Theytaz, F, et al. (2013) Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. Diabetes Care 36, e149e150.
138 Lin, W, Huang, H, Huang, M, et al. (2012) Effects on uric acid, body mass index and blood pressure in adolescents of consuming beverages sweetened with high-fructose corn syrup. Int J Obes 37, 532539.
139 Dodd, KW, Guenther, PM, Freedman, LS, et al. (2006) Statistical methods for estimating usual intake of nutrients and foods: a review of the theory. J Am Diet Assoc 106, 16401650.
140 Angelopoulos, TJ, Lowndes, J, Zukley, L, et al. (2009) The effect of high-fructose corn syrup consumption on triglycerides and uric acid. J Nutr 139, 1242S1245S.
141 Akhavan, T & Anderson, GH (2007) Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men. Am J Clin Nutr 86, 13541363.
142 Buemann, B, Toubro, S, Holst, JJ, et al. (2000) d-Tagatose, a stereoisomer of d-fructose, increases blood uric acid concentration. Metabolism 49, 969976.
143 Wang, DD, Sievenpiper, JL, de Souza, RJ, et al. (2012) The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr 142, 916923.
144 Zgaga, L, Theodoratou, E, Kyle, J, et al. (2012) The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. PLOS ONE 7, e38123.
145 Sun, SZ, Flickinger, BD, Williamson-Hughes, PS, et al. (2010) Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab (Lond) 7, 16.
146 Livesey, G & Taylor, R (2008) Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr 88, 14191437.
147 Livesey, G (2013) Is there really a link between diabetes and the ingestion of fructose? Nutr Bull 38, 337343.
148 Gibson, S (2008) Sugar-sweetened soft drinks and obesity: a systematic review of the evidence from observational studies and interventions. Nutr Res Rev 21, 134147.
149 Ebbeling, CB, Feldman, HA, Osganian, SK, et al. (2006) Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study. Pediatrics 117, 673680.
150 Pollock, NK, Bundy, V, Kanto, W, et al. (2012) Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents. J Nutr 142, 251257.
151 Cullen, KW, Ash, DM, Warneke, C, et al. (2002) Intake of soft drinks, fruit-flavored beverages, and fruits and vegetables by children in grades 4 through 6. Am J Public Health 92, 14751477.
152 Livesey, G (2009) Fructose ingestion: dose-dependent responses in health research. J Nutr 139, 1246S1252S.
153 Sievenpiper, JL & de Souza, RJ (2013) Are sugar-sweetened beverages the whole story? Am J Clin Nutr 98, 261263.
154 Tappy, L & Mittendorfer, B (2012) Fructose toxicity: is the science ready for public health actions? Curr Opin Clin Nutr Metab Care 15, 357361.


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Misconceptions about fructose-containing sugars and their role in the obesity epidemic

  • Vincent J. van Buul (a1), Luc Tappy (a2) and Fred J. P. H. Brouns (a1)


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