Skip to main content
    • Aa
    • Aa

An anti-atherogenic effect of Schistosoma mansoni infections in mice associated with a parasite-induced lowering of blood total cholesterol

  • M. J. DOENHOFF (a1), R. G. STANLEY (a1), K. GRIFFITHS (a2) and C. L. JACKSON (a3)

In affluent societies the prevalences of so-called ‘Western’ diseases such as atherosclerosis, allergies and autoimmune disorders appear to have increased, while many diseases caused by communicable infections are now relatively less common. To test whether there may be a causal relationship we examined the effects of Schistosoma mansoni infections in mice that develop cardiovascular pathology as a result of a genetic deficiency in apolipoprotein E (apoE−/−). The development of atherosclerotic lesions in the aortic arch and brachiocephalic artery of the apoE−/− mice was reduced by approximately 50% in mice with the parasitic infection, when comparison was made with uninfected control mice fed the same diet. Observations on S. mansoni-infected conventional laboratory mice indicate that patent schistosome infections could be counteracting the effects of an atherogenic diet by modulating host lipid metabolism and inducing a reduction in blood total cholesterol concentrations.

Corresponding author
Corresponding author: School of Biological Sciences, University of Wales, Bangor LL57 2UW, UK. E-mail:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 0
Total number of PDF views: 12 *
Loading metrics...

Abstract views

Total abstract views: 117 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 18th August 2017. This data will be updated every 24 hours.