Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 85
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    ATIF, FARHAN AHMAD 2016. Alpha proteobacteria of genus Anaplasma (Rickettsiales: Anaplasmataceae): Epidemiology and characteristics of Anaplasma species related to veterinary and public health importance. Parasitology, Vol. 143, Issue. 06, p. 659.

    Barghash, Safaa M. and El-Naga, Tarek R. Abou 2016. Blood parasites in camels (Camelus dromedarius) in northern west coast of Egypt. Parasite Epidemiology and Control,

    Doyle, Rovaina L. Oliveira, Camila B. França, Raqueli T. Doleski, Pedro H. Souza, Viviane C. Leal, Daniela B.R. Martins, João R. Lopes, Sonia T.A. Machado, Gustavo Da Silva, Aleksandro S. and Andrade, Cinthia M. 2016. Influence of experimental Anaplasma marginale infection and splenectomy on NTPDase and 5'nucleotidase activities in platelets of cattle. Microbial Pathogenesis, Vol. 95, p. 49.

    Ferrolho, Joana Antunes, Sandra Santos, Ana S. Velez, Rita Padre, Ludovina Cabezas-Cruz, Alejandro Santos-Silva, Maria Margarida and Domingos, Ana 2016. Detection and phylogenetic characterization of Theileria spp. and Anaplasma marginale in Rhipicephalus bursa in Portugal. Ticks and Tick-borne Diseases, Vol. 7, Issue. 3, p. 443.

    López, Vladimir Alberdi, Pilar Mera, Isabel G. Fernández de Barasona, José Angel Vicente, Joaquín Garrido, Joseba M. Torina, Alessandra Caracappa, Santo Lelli, Rossella Colomba Gortázar, Christian and de la Fuente, José 2016. Evidence of co-infection with Mycobacterium bovis and tick-borne pathogens in a naturally infected sheep flock. Ticks and Tick-borne Diseases, Vol. 7, Issue. 2, p. 384.

    Rassouli, Maryam Kafshdouzan, Khatereh Zow, Mohammad Saberi and Ghodrati, Sajjad 2016. Blood smear demonstrations of Anaplasma-infected sheep in a flock. Comparative Clinical Pathology, Vol. 25, Issue. 2, p. 331.

    Stuen, S. 2016. Haemoparasites in small ruminants in European countries: Challenges and clinical relevance. Small Ruminant Research,

    Ait Lbacha, H. Alali, S. Zouagui, Z. El Mamoun, L. Rhalem, A. Petit, E. Haddad, N. Gandoin, C. Boulouis, H-J. and Maillard, R. 2015. High Prevalence ofAnaplasmaspp. in Small Ruminants in Morocco. Transboundary and Emerging Diseases, p. n/a.

    Atif, Farhan Ahmad 2015. Anaplasma marginale and Anaplasma phagocytophilum: Rickettsiales pathogens of veterinary and public health significance. Parasitology Research, Vol. 114, Issue. 11, p. 3941.

    da Silva, Jenevaldo Barbosa da Fonseca, Adivaldo Henrique and Barbosa, José Diomedes 2015. Molecular characterization of Anaplasma marginale in ticks naturally feeding on buffaloes. Infection, Genetics and Evolution, Vol. 35, p. 38.

    Esteves, E. Pohl, P.C. Klafke, G.M. Reck, J. Fogaça, A.C. Martins, J.R. and Daffre, S. 2015. Low temperature affects cattle tick reproduction but does not lead to transovarial transmission of Anaplasma marginale. Veterinary Parasitology, Vol. 214, Issue. 3-4, p. 322.

    Jabbar, Abdul Abbas, Tariq Sandhu, Zia-ud-Din Saddiqi, Hafiz A Qamar, Muhammad F and Gasser, Robin B 2015. Tick-borne diseases of bovines in Pakistan: major scope for future research and improved control. Parasites & Vectors, Vol. 8, Issue. 1,

    Kumar, Tarun Sindhu, Neelesh Charaya, Gaurav Kumar, Ankit Kumar, Parmod Chandratere, Gauri Agnihotri, Divya and Khurana, Rajesh 2015. Emerging status of anaplasmosis in cattle in Hisar. Veterinary World, Vol. 8, Issue. 6, p. 768.

    Lis, Katarzyna Fernández de Mera, Isabel G. Popara, Marina Cabezas-Cruz, Alejandro Ayllón, Nieves Zweygarth, Erich Passos, Lygia M.F. Broniszewska, Marzena Villar, Margarita Kocan, Katherine M. Ribeiro, Mucio F.B. Pfister, Kurt and de la Fuente, José 2015. Molecular and immunological characterization of three strains of Anaplasma marginale grown in cultured tick cells. Ticks and Tick-borne Diseases, Vol. 6, Issue. 4, p. 522.

    Oleaga, Ana Obolo-Mvoulouga, Prosper Manzano-Román, Raúl and Pérez-Sánchez, Ricardo 2015. Midgut proteome of an argasid tick, Ornithodoros erraticus: a comparison between unfed and engorged females. Parasites & Vectors, Vol. 8, Issue. 1,

    Potgieter, Marnie Bester, Janette Kell, Douglas B. Pretorius, Etheresia and Danchin, Prof. Antoine 2015. The dormant blood microbiome in chronic, inflammatory diseases. FEMS Microbiology Reviews, Vol. 39, Issue. 4, p. 567.

    Said, Mourad Ben Belkahia, Hanène Alberti, Alberto Zobba, Rosanna Bousrih, Maha Yahiaoui, Mouna Daaloul-Jedidi, Monia Mamlouk, Aymen Gharbi, Mohamed and Messadi, Lilia 2015. Molecular Survey ofAnaplasmaSpecies in Small Ruminants Reveals the Presence of Novel Strains Closely Related toA. phagocytophilumin Tunisia. Vector-Borne and Zoonotic Diseases, Vol. 15, Issue. 10, p. 580.

    Seong, Giyong Han, Yu-Jung Chae, Jeong- Byoung Chae, Joon-Seok Yu, Do-Hyeon Lee, Young-Sung Park, Jinho Park, Bae-Keun Yoo, Jae-Gyu and Choi, Kyoung-Seong 2015. Detection of <i>Anaplasma</i> sp. in Korean Native Goats (<i>Capra aegagrus hircus</i>) on Jeju Island, Korea. The Korean Journal of Parasitology, Vol. 53, Issue. 6, p. 765.

    Teshale, S. Geysen, D. Ameni, G. Asfaw, Y. and Berkvens, D. 2015. Improved molecular detection of Ehrlichia and Anaplasma species applied to Amblyomma ticks collected from cattle and sheep in Ethiopia. Ticks and Tick-borne Diseases, Vol. 6, Issue. 1, p. 1.

    Tuckow, A. P. and Temeyer, K. B. 2015. Discovery, adaptation and transcriptional activity of two tick promoters: Construction of a dual luciferase reporter system for optimization of RNA interference inrhipicephalus(boophilus)micropluscell lines. Insect Molecular Biology, Vol. 24, Issue. 4, p. 454.


Anaplasma marginale (Rickettsiales: Anaplasmataceae): recent advances in defining host–pathogen adaptations of a tick-borne rickettsia

  • K. M. KOCAN (a1), J. DE LA FUENTE (a1), E. F. BLOUIN (a1) and J. C. GARCIA-GARCIA (a1)
  • DOI:
  • Published online: 01 October 2004

The tick-borne intracellular pathogen Anaplasma marginale (Rickettsiales: Anaplasmataceae) develops persistent infections in cattle and tick hosts. While erythrocytes appear to be the only site of infection in cattle, A. marginale undergoes a complex developmental cycle in ticks and transmission occurs via salivary glands during feeding. Many geographic isolates occur that vary in genotype, antigenic composition, morphology and infectivity for ticks. In this chapter we review recent research on the host–vector–pathogen interactions of A. marginale. Major surface proteins (MSPs) play a crucial role in the interaction of A. marginale with host cells. The MSP1a protein, which is an adhesin for bovine erythrocytes and tick cells, is differentially regulated and affects infection and transmission of A. marginale by Dermacentor spp. ticks. MSP2 undergoes antigenic variation and selection in cattle and ticks, and contributes to the maintenance of persistent infections. Phylogenetic studies of A. marginale geographic isolates using msp4 and msp1α provide information about the biogeography and evolution of A. marginale: msp1α genotypes evolve under positive selection pressure. Isolates of A. marginale are maintained by independent transmission events and a mechanism of infection exclusion in cattle and ticks allows for only the infection of one isolate per animal. Prospects for development of control strategies by use of pathogen and tick-derived antigens are discussed. The A. marginale/vector/host studies described herein could serve as a model for research on other tick-borne rickettsiae.

Corresponding author
Katherine M. Kocan, Ph.D., Department of Veterinary Pathobiology, 250 McElroy Hall, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078-2007. Tel: (405) 744-7271. Fax: (405) 744-5275. E-mail:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *