Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-06-09T10:20:28.644Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of Ostertagia circumcincta infections on plasma gastrin in sheep

Published online by Cambridge University Press:  06 April 2009

N. Anderson ,
J. Hansky  and
D. A. Titchens
N. Anderson
Affiliation:
Animal Health Division of the O.S.J.R.O. Parkville, Victoria
J. Hansky
Affiliation:
Department of Medicine Prince Henry Hospital, Prahran, Victoria, Australia
D. A. Titchens
Affiliation:
Department of Veterinary Preclinical Sciences, University of Melbourne Parkville, Victoria
Get access Rights & Permissions [Opens in a new window]

Summary

Radio-immunoassay of plasma gastrin showed that hypergastrinaemia developed in sheep during experimental infections with Ostertagia circumcincta. Elevations of plasma gastrin occurred within 8 days of the first dose of infective larvae, with the most marked increase being after 11–20 days when adult worms would be expected to be present in the abomasum. Increases of plasma gastrin levels from 69·0 ± 7·6, 28·7 ± 5·3, 48·7 ± 5·9 and 60·6 ± 9·4 pg/ml before infection to maxima of 650, 230, 900 and 750 pg/ml respectively were recorded in 4 sheep infected for the first time. In 2 others which had been previously infected and then treated with anthelmintic, plasma gastrin rose from 16·0 ± 4·0 and 377 ± 87 pg/ml to maxima of 260 and 900 pg/ml at 24 and 29 days after re-infection, respectively. The cause of hypergastrinaemia has not been established. The elevation of abomasal pH which occurs in ostertagiasis may result in increased gastrin levels but is thought not to be the only cause since plasma gastrin increased before the abomasal pH rose and developed in sheep infected for a second time although their abomasal contents remained at pH 4·0 or lower. The presence of the parasite is critical for development of hypergastrinaemia as shown by return of the gastrin level to normal following therapy with an anthelmintic. It was shown that the parasites do not depend on the hypergastrinaemia since O. circumcincta became established in antrectomized sheep in which hypergastrinaemia did not develop.

Type
Research Article
Information
Parasitology , Volume 82 , Issue 3 , June 1981 , pp. 401 - 410
Copyright
Copyright © Cambridge University Press 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anderson, N., Armour, J., Jarrett, W. R. H., Jennings, F. W., Ritchie, J. D. S. & Urquhart, G. M. (1965). A field study of parasitic gastritis in cattle. Veterinary Record 77, 1196–204.CrossRefGoogle ScholarPubMed
Anderson, N., Blake, R. & Titchen, D. A. (1976). Effects of a series of infections of Ostertagia circumcincta on gastric secretion of sheep. Parasitology 72, 1–12.CrossRefGoogle ScholarPubMed
Anderson, N., Hansky, J. & Titchen, D. A. (1976). Hypergastrinaemia during a parasitic gastritis in sheep. Journal of Physiology 256, 51–2P.Google ScholarPubMed
Anderson, W. R., Fletcher, T. L., Pitts, C. L. & Hawkins, H. N. (1962). Isolation and assay of ovine gastrin. Nature, London 193, 1286–7.CrossRefGoogle ScholarPubMed
Becker, H. D., Reeder, D. D. & Thompson, J. C. (1973). The effects of changes in antral pH on the basal release of gastrin. Proceedings of the Society of Experimental Biology and Medicine 143, 238–40.CrossRefGoogle ScholarPubMed
Carr, D. H., McLeay, L. M. & Titchen, D. A. (1969). Factors affecting reflex responses of the ruminant stomach. In Physiology and Metabolism in the Ruminant, (ed. Phillipson, A. T.), pp. 35–41. Newcastle upon Tyne: Oriel Press.Google Scholar
Crean, G. P., Marshall, M. W. & Rumsey, R. D. E. (1969). Parietal cell hyperplasia induced by the administration of pentagastrin (ICI 50, 123) to rats. Gastroenterology 57, 147–55.CrossRefGoogle ScholarPubMed
Creutzfeldt, W., Arnold, R., Creutzfeldt, C., Feurle, G. & Ketterer, H. (1971). Gastrin and G cells in the antral mucosa of patients with pernicious anemia, acromegaly and hyperparathyroidism and in a Zollinger-Ellison tumour of the pancreas. European Journal of Clinical Investigation 1, 461–79.CrossRefGoogle Scholar
Hansky, J. (1974). Clinical aspects of gastrin physiology. Medical Clinics of North America 58, 1217–30.CrossRefGoogle ScholarPubMed
Hansky, J., Korman, M. G., Soveny, C. & St John, D. J. B. (1971). Radioimmunoassay of gastrin: studies in pernicious anaemia. Gut 12, 97–101.CrossRefGoogle ScholarPubMed
Hansky, J., Soveny, C. & Korman, M. G. (1971). Effect of secretion on serum gastrin as measured by radioimmunoassay. Gastroenterology 61, 62–8.CrossRefGoogle Scholar
Johnson, L. R. (1974). Gut hormones on growth of gastrointestinal mucosa. In Endocrinology of the Gut, (ed. Chey, W. Y. and Possoocks, F. P.). New Jersey: Charles B. Slack, Inc.Google Scholar
McLeay, L. M., Anderson, N., Bingley, J. B. & Tichen, D. A. (1973). Effects on abomasal function of Ostertagia circumcincta infections in sheep. Parasitology 66, 241–57.CrossRefGoogle ScholarPubMed
McLeay, L. M. & Jury, D. R. (1976). Gastrin-like activity in the fore-stomach, abomasum and intestine of the sheep. Journal of Physiology 265, 57P.Google Scholar
McLeay, L. M. & Titchen, D. A. (1970). Abomasal secretory responses to teasing with food and feeding in the sheep. Journal of Physiology 206, 605–28.CrossRefGoogle ScholarPubMed
McLeay, L. M. & Titchen, D. A. (1974). Effects of the amount and type of food eaten on secretion from fundic abomasal pouches of sheep. British Journal of Nutrition 32, 375–87.CrossRefGoogle ScholarPubMed
McLeay, L. M. & Titchen, D. A. (1975). Gastric, antral and fundic pouch secretion in sheep. Journal of Physiology 248, 595–612.CrossRefGoogle ScholarPubMed
McLeay, L. M. & Titchen, D. A. (1977 a). Acid and pepsin secretion of separated gastric pouches during perfusion of antral pouches with cholinergic stimulating and blocking agents and lignocaine. Journal of Physiology 264, 215–27.CrossRefGoogle ScholarPubMed
McLeay, L. M. & Titchen, D. A. (1977 b). Inhibition of hydrochloric acid and pepsin secretion from gastric pouches by antral pouch acidification in sheep. Journal of Physiology 273, 707–16.CrossRefGoogle ScholarPubMed
Mutt, V. (1978). Hormone isolation. In Gut Hormones, (ed. Bloom, S. R.), pp. 21–27. Edinburgh: Churchill Livingstone.Google Scholar
Reynolds, G. W., Anderson, N., Stiffe, G., Hansky, J. & Titchen, D. A. (1979). Ovine tissue and serum gastrin in ostertagiasis. Annales de recherches vétérinaires 10, 341–3.Google ScholarPubMed