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Micromotility meter: an instrument designed to evaluate the action of drugs on motility of larval and adult nematodes

Published online by Cambridge University Press:  06 April 2009

J. L. Bennett  and
R. A. Pax
J. L. Bennett
Affiliation:
Departments of Pharmacology, Toxicology and Zoology, Michigan State University, East Lansing, Michigan 48824
R. A. Pax
Affiliation:
Departments of Pharmacology, Toxicology and Zoology, Michigan State University, East Lansing, Michigan 48824
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Summary

An instrument for measuring the motility of larval and adult nematodes is described along with an analysis of its use as a tool to analyse drug action on these parasites. Motility was detected from larval parasites of Nippostrongylus brasiliensis and Ascaris suum in the absence and presence of various anti-nematodal drugs. These agents produced, within 48 h, a significant decrease in larval parasite motility. The instrument was also capable of detecting the motility of Caenorhabditis elegans, adult female Brugia pahangi and their response to anti-nematodal drugs. The design of the instrument allows us to accurately measure motility in a single sample within 60 sec.

Type
Research Article
Information
Parasitology , Volume 93 , Issue 2 , October 1986 , pp. 341 - 346
Copyright
Copyright © Cambridge University Press 1986

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