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The modes of action of some anti-protozoal drugs

Published online by Cambridge University Press:  06 April 2009

R. E. Howells
R. E. Howells
Affiliation:
Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA
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Extract

In spite of the continuing need for new and improved anti-protozoal drugs for use in man, a considerable contraction of industrially based research on anti-protozoal drugs has occurred in recent years. Newton (1983) reviewed the reasons for this decline and presented a compelling argument that fundamental research on the biology of the parasites is essential for the discovery of leads for the development of a new generation of drugs – a rational chemotherapy. The rapid advance in knowledge of the biochemistry of parasitic protozoa which has occurred in recent years has provided a number of potential leads to new drug development and has permitted a greater understanding of the mode of action of many current drugs. The account of these advances which follows is necessarily selective and relates to protozoan parasites of man.

Type
Research Article
Information
Parasitology , Volume 90 , Issue 4 , April 1985 , pp. 687 - 703
Copyright
Copyright © Cambridge University Press 1985

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