Hostname: page-component-848d4c4894-wg55d Total loading time: 0 Render date: 2024-05-16T03:01:43.277Z Has data issue: false hasContentIssue false
  • English
  • Français

Role of adult worms in immunity of rats to Nippostrongylus brasiliensis

Published online by Cambridge University Press:  06 April 2009

Bridget M. Ogilvie
Bridget M. Ogilvie
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Madingley Road, Cambridge
Get access Rights & Permissions [Opens in a new window]

Extract

Immunity to N. brasiliensis in rats is stimulated primarily by the adult worms. An initial infection consisting solely of adult worms terminated at the same time as an infection consisting of all the parasitic stages.

Immunity is not stage specific. Immunity stimulated by adult worms acts not only on adult stages inhibiting their reproduction but also inhibits the development to maturity of larvae in a challenge infection.

Rats infected solely with female adult worms, whether egg producing or sterile, are more resistant to reinfection than rats infected with male worms only.

Immunity stimulated by a single normal infection lasts a long time but it does not depend on the persistence of adult worms in the intestine of the rats.

This work was done during the tenure of a Commonwealth Scholarship awarded by the Association of Commonwealth Universities.

Type
Research Article
Information
Parasitology , Volume 55 , Issue 2 , May 1965 , pp. 325 - 335
Copyright
Copyright © Cambridge University Press 1965

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Africa, C. M. (1931). Studies on the host relations of Nippostrongylus muris, with special reference to age resistance and acquired immunity. J. Parasit. 18, 1–13.CrossRefGoogle Scholar
Ashley, W. (1964). Development of irradiated Nippostrongylus brasiliensis larvae and the immunogenic effect produced in rats. J. Parasit. 50 (section 2), p. 27.Google Scholar
Anderson, C. V. & Leonard, A. B. (1940). Immunity produced in rats by the intestinal phase of Trichinella infection. J. Parasit. (Suppl.), 26, 42–3.Google Scholar
Chandler, A. C. (1932). Experiments on resistance of rats to superinfection with the nematode, Nippostrongylus muris. Amer. J. Hyg. 16, 750–82.Google Scholar
Chandler, A. C. (1936). Studies on the nature of immunity to intestinal helminths. IV. The inter-relations between parenteral and intestinal immunity in rats infected with Nippostrongylus. Amer. J. Hyg. 24, 129–44.Google Scholar
Graham, G. L. (1934). Resistance studies with the nematode, Nippostrongylus muris, in laboratory rats. Amer. J. Hyg. 20, 352–372.Google Scholar
Jennings, F. W., Mulligan, W. & Urquhart, G. M. (1963). Variables in X-ray ‘inactivation’ of Nippostrongylus brasiliensis larvae. Expl Parasit. 13, 367–373.CrossRefGoogle ScholarPubMed
Keeling, J. E. D. (1960). The effects of ultra-violet radiation on Nippostrongylus muris. 1. Irradiation of infective larvae: lethal and sublethal effects. Ann. trop. Med. Parasit. 54, 181–191.CrossRefGoogle Scholar
Ogilvie, B. M. (1962). The importance of adult worms in Nippostrongylus brasiliensis infections. Parasitology, 52, 6p.Google Scholar
Ogilvie, B. M. (1964). Nippostrongylus brasiliensis (Travassos, 1914; Travassos & Darriba, 1929). A study of the life cycle and the immunological response of the host. Dissertation, University of Cambridge, U.K.Google Scholar
Ross, J. G. (1963). The role of the larval stages of Haemonchus placei infections of cattle in immunity. J. Helminth. 37, 359–68.CrossRefGoogle ScholarPubMed
Sarles, M. P. & Taliaferro, W. H. (1936). The local points of defense and the passive transfer of acquired immunity to Nippostrongylus muris in rats. J. infect. Dis. 59, 207–220.CrossRefGoogle Scholar
Silverman, P. H. & Patterson, J. E. (1960). Histotrophic (parasitic) stages of Haemonchus contortus. Nature, Lond., 185, 54–5.CrossRefGoogle ScholarPubMed
Smithers, S. R. (1962). Stimulation of acquired resistance to Schistosoma mansoni in monkeys: role of eggs and worms. Expl Parasit. 12, 263–73.CrossRefGoogle ScholarPubMed
Soulsby, E. J. L. (1959). The importance of the moulting period in the stimulation of immunity to helminths. Proc. Int. Vet. Congr., Madrid. IIc, 571.Google Scholar
Soulsby, E. J. L. (1961). Immune mechanisms in helminth infections. Vet. Rec. 73, 1053–8.Google ScholarPubMed
Spindler, L. A. (1936). Resistance of rats to infection with Nippostrongylus muris following administration of the worms by duodenal tube. Amer. J. Hyg. 23, 237–42.Google Scholar
Whitlock, H. V. (1948). Some modifications of the McMaster helminth egg-counting technique and apparatus. J. Coun. sci. industr. Res. Aust. 21, 177–80.Google Scholar