Hostname: page-component-848d4c4894-x24gv Total loading time: 0 Render date: 2024-05-18T01:20:22.041Z Has data issue: false hasContentIssue false
  • English
  • Français

Use of immunological manipulations in studying genetically controlled responses to Leishmania donovani infection in mice

Published online by Cambridge University Press:  23 August 2011

Jenefer M. Blackwell
Jenefer M. Blackwell
Affiliation:
Department of Tropical Hygiene, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
Get access Rights & Permissions [Opens in a new window]

Extract

In the preceding paper Howard (p. 665) has given a very elegant presentation on ways in which the host immune system may be manipulated to provide valuable information about immunoregulation of parasitic infection in vivo. In our laboratory we have used some of the same manoeuvres to study immunoregulation of genetically controlled responses to Leishmania donovani infection in inbred mouse strains (Ulczak & Blackwell, 1983; Crocker, Blackwell & Bradley, 1984). As has been Howard's experience, the results obtained have not always been as one might have predicted at the outset.

Type
Research Article
Information
Parasitology , Volume 88 , Issue 4: Symposia of the British Society for Parasitology Volume 21: Parasite evasion of the immune response , August 1984 , pp. 677 - 679
Copyright
Copyright © Cambridge University Press 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Blackwell, J., Freeman, J. & Bradley, D. (1980). Influence of H-2 complex on acquired resistance to Leishmania donovani infection in mice. Nature, London 283, 72–4.CrossRefGoogle ScholarPubMed
Blackwell, J. M., Ulczak, O. M. & Channon, J. Y. (1983). Immunogenetics and immuno-regulation of parasitic infection in mice with specific reference to leishmaniasis. In Experimental Models of Bacterial and Parasitic Infections (ed. Keusch, G. T. & Wadstrom, T.), pp. 365–73. New York: Elsevier.Google Scholar
Bradley, D. J. & Kirkley, J. (1977). Regulation of Leishmania populations within the host. I. The variable course of Leishmania donovani infections in mice. Clinical and Experimental Immunology 30, 119–29.Google ScholarPubMed
Crocker, P. R., Blackwell, J. M. & Bradley, D. J. (1984). Transfer of resistance and susceptibility to Leishmania donovani infection in mouse radiation bone marrow chimaeras. Immunology (in the Press).Google Scholar
Hale, C. & Howard, J. G. (1981). Immunological regulation of experimental cutaneous leishmaniasis. 2. Studies with Biozzi high and low responder lines of mice. Parasite Immunology 3, 45–55.Google Scholar
Hormaeche, C. E., Brock, J. & Pettifor, R. (1980). Natural resistance to mouse typhoid: possible role of the macrophage. In Genetic Control of Natural Resistance to Infections and Malignancy (ed. Skamene, E.Kongshavn, P. and Landy, M.), pp. 121–32. New York: Academic Press.Google Scholar
Olobo, J. O., Handman, E., Curtis, J. M. & Mitchell, G. F. (1980). Antibodies to Leishmania tropica promastigotes during infection in mice of various genotypes. Australian Journal of Experimental Biological and Medical Sciences 58, 595–601.CrossRefGoogle ScholarPubMed
Skov, C. B. & Twohy, D. W. (1974). Cellular immunity to Leishmania donovani. I. The effect of T cell depletion on resistance to L. donovani in mice. Journal of Immunology 113, 2004–11.Google Scholar
Ulczak, O. M. & Blackwell, J. M. (1983). Immunoregulation of genetically controlled acquired responses to Leishmania donovani infection in mice: the effects of parasite dose, cyclophosphamide and sublethal irradiation. Parasite Immunology 5, 449–63.CrossRefGoogle ScholarPubMed